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(https://isappscience.org/wp-content/uploads/2025/07/Greiner-cover.png) This episode features Dr. Thomas Greiner PhD from the University of Gothenburg (Sweden), speaking about the various functions of GLP-1 in the gut, and the role of gut microbes in GLP-1 production, with ultimate effects on host health. He noted that GLP-1 is produced by enteroendocrine cells called L-cells, both in the small intestine and the colon. These cells respond to nutrients and microbially-produced short-chain fatty acids, but responses differ between the small intestine and colon, leading Dr. Greiner to investigate the different functions of GLP-1 at these two sites. Using germ-free mice and other models, Dr. Greiner has developed a hypothesis that the function of GLP-1 in the small intestine is to improve insulin secretion postprandially, whereas the functions of GLP-1 in the colon are to allow for increased energy intake (in a situation of energy deficiency), dampen inflammation, and protect local tissues. He and his colleagues are taking two different approaches in aiming to improve metabolic health in humans: finding inhibitors of bacterial enzymes to decrease production of a harmful molecule produced by bacteria; and a probiotic approach of administering butyrate-producing bacteria. With the latter approach, the sensitivity of the bacteria to oxygen is a problem to overcome, but their group has evolved a bacterial strain to tolerate some oxygen, with the idea of testing it as a probiotic. Episode abbreviations and links: • Paper exploring the role of the gut microbiota in GLP-1 signaling: GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota (https://www.sciencedirect.com/science/article/pii/S2212877824000553?via%3Dihub) • Study on the functions of GLP-1 in the colon: Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(13)00365-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS193131281300365X%3Fshowall%3Dtrue) • Bäckhed Lab Instagram account: @backhed_lab (https://www.instagram.com/backhed_lab?igsh=MWdpdmlndDAxOWFjag==) About Dr. Thomas Greiner PhD: Thomas Greiner is a medical scientist at the Wallenberg Laboratory, University of Gothenburg, with over 15 years of experience in functional genetics and metabolic research. His work focuses on the intricate interplay between gut microbiota, intestinal hormones such as GLP-1, and host metabolism. He has explored how microbial and hormonal signals influence energy balance, intestinal function, and the development of metabolic diseases. His research primarily uses molecular approaches in mouse models to investigate the role of microbial signals in metabolic disease and to uncover new functions of gut hormones in regulating intestinal physiology. Sign up (https://isappscience.org/for-scientists/news/isapp-newsletters/) for our monthly newsletter Follow us (https://isappscience.org/contact/) on LinkedIn, Bluesky, X, Facebook, Instagram, Threads The post Unraveling the functions of GLP-1 in the gut, with Dr. Thomas Greiner PhD (https://isappscience.org/episode-65-unraveling-the-functions-of-glp-1-in-the-gut/) appeared first on International Scientific Association for Probiotics and Prebiotics (ISAPP) (https://isappscience.org) .
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Apple cider vinegar (ACV) has been touted as a weight loss aid for many years, thanks to its potential to boost metabolism, reduce appetite, and help burn fat. Keto gummies infused with ACV have become a popular way for people to enjoy the benefits of ACV while also following a ketogenic diet. ACV Keto gummies combine the power of ACV with the fat-burning properties of the keto diet, making them a potent tool for weight loss and overall health.
Real-Life Success Stories with ACV Keto Gummies
Many people have tried ACV Keto gummies and have seen amazing results in their weight loss journey. These real-life success stories serve as inspiration for others who are looking to incorporate ACV Keto gummies into their daily routine. Here are some before and after stories from individuals who have experienced the transformative effects of ACV Keto gummies.
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Emily’s Journey with ACV Keto Gummies
Emily had struggled with her weight for years, trying numerous diets and weight loss supplements without much success. After hearing about the benefits of ACV and the keto diet, she decided to give ACV Keto gummies a try. Within just a few weeks, Emily noticed a significant difference in her energy levels and overall well-being. She continued taking the gummies as part of her daily routine and after several months, she had lost over 30 pounds. Emily’s before and after photos show a remarkable transformation, and she couldn’t be happier with the results.
Mike’s Experience with ACV Keto Gummies
Mike had always been skeptical of weight loss supplements, but after seeing his friend’s success with ACV Keto gummies, he decided to give them a try. Mike had been following a keto diet for some time, but he was looking for an extra boost to help him reach his weight loss goals. After incorporating ACV Keto gummies into his routine, Mike noticed a significant decrease in his cravings for unhealthy foods and a boost in his metabolism. He also saw a noticeable difference in his waistline, losing over 20 pounds in just a few months. Mike continues to take ACV Keto gummies as part of his weight loss maintenance plan.
Sarah’s Transformation with ACV Keto Gummies
Sarah had always struggled with her weight, trying countless diets and exercise routines with little to no success. She had heard about the benefits of ACV for weight loss but found it difficult to incorporate into her daily routine. When she discovered ACV Keto gummies, Sarah was thrilled to have a convenient and tasty way to enjoy the benefits of ACV. After just a few weeks, Sarah noticed a decrease in her appetite and an increase in her energy levels. With consistent use of ACV Keto gummies, Sarah was able to lose over 25 pounds and achieve the slim figure she had always dreamed of.
Adam’s Success Story with ACV Keto Gummies
Adam had tried countless diets and weight loss supplements without much success, until he discovered ACV Keto gummies. Adam had been following a strict keto diet for some time, but he was looking for an extra boost to help him shed those last few stubborn pounds. After incorporating ACV Keto gummies into his routine, Adam noticed a significant increase in his energy levels and a decrease in his cravings for unhealthy foods. He also saw a noticeable difference in his body composition, losing over 15 pounds in just a few months. Adam continues to take ACV Keto gummies to maintain his weight loss and overall health.
Jenna’s Journey with ACV Keto Gummies
Jenna had struggled with her weight for years, trying fad diets and weight loss supplements without much success. After hearing about the benefits of ACV and the keto diet, she decided to give ACV Keto gummies a try. Within a few weeks, Jenna noticed a significant decrease in her appetite and an increase in her metabolism. She continued taking the gummies as part of her daily routine and after several months, she had lost over 30 pounds. Jenna’s before and after photos show a remarkable transformation, and she couldn’t be happier with the results.
Summary and FAQ
ACV Keto gummies have become a popular choice for individuals looking to lose weight and improve their overall health. By combining the power of ACV with the fat-burning properties of the keto diet, ACV Keto gummies offer a convenient and effective way to support weight loss goals. The real-life success stories of individuals like Emily, Mike, Sarah, Adam, and Jenna serve as inspiration for others who are considering incorporating ACV Keto gummies into their daily routine.
FAQ:
1. Are ACV Keto gummies safe to take?
Yes, ACV Keto gummies are generally safe to take as they are made from natural ingredients. However, it is always best to consult with a healthcare provider before adding any new supplement to your routine.
2. How do ACV Keto gummies help with weight loss?
ACV Keto gummies contain apple cider vinegar, which has been shown to boost metabolism, reduce appetite, and help burn fat. When combined with the ketogenic diet, ACV Keto gummies can support weight loss goals.
3. How long does it take to see results with ACV Keto gummies?
Individual results may vary, but many people report seeing noticeable results within a few weeks of incorporating ACV Keto gummies into their daily routine. Consistent use over several months can lead to significant weight loss and overall health improvements.
