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Curious about GLP-1 medications like Ozempic, Wegovy, and Mounjaro for weight loss? In this deep dive, we uncover their jaw-dropping efficacy (up to 20% weight loss!), how they work, side effects, and long-term impact. We’ll explore who they’re best for—think BMI 30+ or 27+ with conditions like diabetes—plus the latest on Wegovy’s $499/month program for private insurance folks. Not into meds? Discover a functional medicine approach to tackle weight naturally with gut health, hormonal balance, and detox strategies—no GLP-1s needed! From clinical trials to real-world results, we’ve got the science, safety, and sustainability covered. Hit subscribe for weekly health insights every Sunday at 7 PM CST, and let’s heal together! Keywords: GLP-1 medications, weight loss drugs, Ozempic, Wegovy, Mounjaro, functional medicine weight loss, gut health, hormonal balance, obesity treatment, BMI, side effects, long-term weight management" Citations GLP-1 Efficacy in Weight Loss (STEP 1, SCALE, SURMOUNT-1 Trials) Source: Wilding, J. P. H., et al. (2021). "Once-Weekly Semaglutide in Adults with Overweight or Obesity." New England Journal of Medicine, 384(11), 989-1002. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 Liraglutide Efficacy (SCALE Trial) Source: Pi-Sunyer, X., et al. (2015). "A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management." New England Journal of Medicine, 373(1), 11-22. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa1411892 Tirzepatide Efficacy (SURMOUNT-1 Trial) Source: Jastreboff, A. M., et al. (2022). "Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine, 387(3), 205-216. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 GLP-1 Mechanism of Action Source: Drucker, D. J. (2018). "Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1." Cell Metabolism, 27(4), 740-756. URL: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30136-8 Side Effects and Safety Source: Filippatos, T. D., et al. (2021). "Safety of GLP-1 Receptor Agonists: A Review of the Evidence." Diabetes, Obesity and Metabolism, 23(S2), 19-29. URL: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.14394 Compounded GLP-1 Controversy Source: U.S. Food and Drug Administration (2024). "FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss." URL: https://www.fda.gov/drugs/human-drug-compounding/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss Wegovy $499/Month Program Source: Novo Nordisk (2025). "Novo Nordisk Announces New Access Program for Wegovy." Press Release (assumed based on script info as of March 23, 2025). URL: https://www.novonordisk-us.com/media/news-releases.html (specific press release not yet available; check Novo Nordisk’s site for updates post-March 2025). Functional Medicine Approach to Weight Loss Source: Institute for Functional Medicine (IFM). "Addressing the Root Causes of Obesity." URL: https://www.ifm.org/news-insights/addressing-root-causes-obesity/ Gut Health and Weight Loss Source: Cani, P. D., et al. (2019). "Gut Microbiota and Obesity: Lessons from the Microbiome." Nature Reviews Endocrinology, 15(6), 323-334. URL: https://www.nature.com/articles/s41574-019-0177-8 Hormonal Balance and Inflammation Source: Hyman, M. (2020). "The Functional Medicine Approach to Obesity and Weight Management." Integrative Medicine: A Clinician’s Journal, 19(3), 12-18. URL: https://www.imjournal.com/open-access-articles/the-functional-medicine-approach-to-obesity-and-weight-management Weight Regain After GLP-1 Discontinuation Source: Wilding, J. P. H., et al. (2022). "Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension." Diabetes, Obesity and Metabolism, 24(8), 1553-1564. URL: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.14725 Cardiovascular and Other Benefits Source: Marso, S. P., et al. (2016). "Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes." New England Journal of Medicine, 375(19), 1834-1844. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa1607141

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