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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Sign up for updates about each new episode: https://info.insidetracker.com/longevitybydesign View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1 Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity.   The Impact of GLP-1 on Fertility Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences. “If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.” We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcastShocking Weight Loss Facts What To Eat To Burn Fat Fast Dramir Shahzad

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Acclaimed by ever more people of the super-popular keto diets, Shark Tank Super Slim Keto Gummies became an undisputed recommendation for its fat burning effect and weight loss help. Shark Tank Super Slim Keto Gummies: What Are These Gummies and How Do They Work? Let’s take a look at the benefits and worries to figure out whether these amazing fruits can work for you!

Benefits of Shark Tank Super Slim Keto Gummies

1.Metabolism Booster: Shark Tank Super Slim Keto Gummies can speed up your metabolism. That means you’ll feel more energetic and be able to burn calories at a faster rate. With an improved metabolism and faster calorie-burning capability, you’ll see results in no time at all!

2. Appetite Suppression: These gummies can supress appetite by making you feel full for longer periods of time, thus avoiding overeating and ingesting unnecessary calories, which will, in turn, lead to healthy, lasting weight loss.

3. Skyrocketing Energy Levels: At the same time, Shark Tank Super Slim Keto Gummies can help your energy levels shoot up without increasing stress hormones, making you feel more energetic and active throughout the day, which allows you to make the most of your workouts, and lose more weight than ever before.

Concerns about Shark Tank Super Slim Keto Gummies

1. With No Regulation In The Dietary Supplement Industry: Because dietary supplements is a branch of nutrition that we do not advocate for, we simply wish to bring attention to the fact that there is no regulation in the dietary supplements industry, which makes it very easy to produce products like Shark Tank Super Slim Keto Gummies without ensuring that they do not have any harmful side effects.

2) Side Effects: Consumption of Shark Tank Super Slim Keto Gummies may lead to minor side effects like nausea, vomiting, headache, jitters etc. You must get advice from your doctor before using these gummies to ensure it is safe for you.

3) It is not Magically Effective: While Shark Tank Super Slim Keto Gummies can help users lose weight successfully, they aren’t magic. You need to use them as part of a healthy diet and participate in regular exercise in order to achieve your target weight.

Summary and FAQ

All in all, Shark Tank Super Slim Keto Gummies are bestowed with so many virtues and health benefits, and it makes sense to utilize it to your advantage. Unlike most other weight loss products, it has properties that can help you burn fat, suppress your appetite until your body can handle the deficit in calories, as well as boost your energy. But, just keep in mind that the buck doesn’t stop there, because the gummies are not properly regulated, and that there could be some side effects. Remember to do your due diligence and talk to your doctor before using these gummies to lose weight.

FAQ:

1. Are Shark Tank Super Slim Keto Gummies safe to use?

We recommend that anyone planning to include any dietary supplement in their regimen consult first with a health care professional to determine whether it is a good choice for them. These gummies may not be appropriate for those who are prone to hyposulphitaemia or who are allergic to certain ingredients such as flax, algae or apple.

2. How should I use Shark Tank Super Slim Keto Gummies for best results?

It is recommended to take gummies as indicated on its package or take advice from your doctor and couple it with a healthy diet and an active lifestyle.

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