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Downsized News: Breakthroughs and Industry Shifts in GLP-1 Treatments In this episode of the Downsized News, Laraine and Christopher Durham deliver the latest updates on GLP-1 medications on Monday, June 2nd, 2025. Key topics include significant data releases by Eli Lilly at the upcoming American Diabetes Association's Scientific Sessions concerning Tirzepatide's effects on kidney function and weight loss compared to Semaglutide. The episode also explores new forms of GLP-1 treatments, such as the Orfroglipron pill and the Retatrutide triple-action hormone, as well as an updated weekly insulin option by Lilly. Additionally, a comprehensive breakdown of a study on high-dose Semaglutide treatments for diabetes and obesity discusses the balance between increased weight loss and rising side effects. The discussion shifts to industry challenges, like Hims Inc.'s layoffs due to FDA crackdowns on compounded GLP-1s, and a new ISSA course designed to help athletic trainers support GLP-1 users. Also covered is the intense industry debate over compounded medications, a major court ruling in India impacting Semaglutide sales, and competitive developments in China's obesity treatment market. The episode concludes with highlights of an innovative partnership between Nxtera Pharma and Eli Lilly aiming at new metabolic treatments. The hosts encourage viewers to stay informed and share personal insights on navigating GLP-1 treatments. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:04 Eli Lilly's Latest Data and Innovations 05:21 High Dose Semaglutide Study Insights 10:14 Hims Layoffs and FDA Crackdown 11:51 New Training Course for GLP-1 Trainers 13:58 Compounded Medications Debate 17:08 Legal Battles and Market Dynamics in India 20:16 NextEra Pharma and Eli Lilly Partnership 21:52 Upcoming Competition in China's GLP-1 Market 24:25 Conclusion and Final Thoughts

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Dr. Jennifer Landa, Chief Medical Officer of BodyLogicMD, touches on the use of semaglutide, a GLP-1 agonist, for weight loss, which regulates appetite and improves insulin function. Dr. Landa discusses the impact of hormone imbalance on weight gain. She highlights the dangers of being overweight or obese and explains the role of hormones in weight regulation, such as leptin, ghrelin, and insulin. She also introduces the concept of leptin resistance and promises to delve deeper into the topic in future discussions.

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In this evidence-based video, we break down the pharmacology of GLP-1 receptor agonists (GLP-1 RAs)—a rapidly expanding class of antidiabetic and weight-loss medications. Designed for physicians, pharmacists, nurse practitioners, and other healthcare professionals, this video covers: ✅ Mechanism of action ✅ Pharmacokinetics and pharmacodynamics ✅ Differences between short-acting vs long-acting agents ✅ Clinical indications (T2DM, obesity) ✅ Cardiovascular and renal benefits ✅ Common side effects and safety profile ✅ Overview of agents like liraglutide, semaglutide, dulaglutide, and more 00:00 Intro & Incretins 01:28 Mechanism of action 05:23 GLP-1 RA Members 06:28 Side Effects 06:53 Benefits 08:02 Contraindications 08:30 First line for? 10:03 Dosing and Trade names 14:45 Growing Evidence Create a PowerPoint like this: https://gamma.app/signup?r=fhjwoprdsktd11u Join our Facebook group: https://www.facebook.com/ReadyResident Support me via Instapy: https://ipn.eg/S/elmisiry/instapay/2xuNe7 📚 Key Guidelines Referenced: BMJ Best Practice (2025) ADA 2025, WHO, and leading endocrinology resources 📚 Evidence-based and updated with the latest guideline recommendations (ADA, ESC, KDIGO). 📢 Like, share, and subscribe for more evidence-based emergency medicine and surgical tutorials. 🔔 Turn on notifications so you don’t miss our next case-based simulation!

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Join me on my personal journey as I share my honest experience of embracing a fresh start after gaining 40lbs, and how I'm working to regain control of my fitness journey. In this video, I open up about my struggles with weight loss and self-love, and how I'm learning to focus on progress, not perfection. From setbacks to successes, I'm committed to sharing my authentic story in the hopes of inspiring others who may be on a similar path. Let's take the first step towards a healthier, happier us together! Hume Body Pod Discount Link: https://t.ly/TcfYA Code: MINDY Macro Friendly Food Discount Link- https://macrofriendlyfood.com/ref/94/ (Enter code mindyp10 for 10% off your subscription) 14-day free Trainwell trial: https://go.trainwell.net/mindy Support my content: https://www.buymeacoffee.com/mindyp MY DISCORD SERVER - https://discord.gg/mJsSnPYhyy IG/FB - @mindypweightloss Pinterest - www.pinterest.com/mindypweightloss Built Bar Discount Link- https://builtbar.com?baapp=MINDYP10 (Enter code MINDYP10 for 10% off your order) WRITE ME [email protected] Links: Free Sharps Container - https://www.novocare.com/diabetes/resources/safe-disposal.html My Amazon Affiliate Store - https://www.amazon.com/shop/mindypedersen (I receive a small commission but it does not increase your cost. You are not obligated in any way to use them. ) RECIPES Strawberry Protein Fluff (Makes 4 servings) 24oz Non-Fat Cottage Cheese 0.3oz Sugar-free Strawberry Jello 1lb Strawberries 4oz Fat-Free Cool Whip 1oz Chopped Pistachios My Favorite Recipe Sites / IG accounts: @elyseaellis @makayla_thomas_fit @the_plant_slant @iheartmacros @theflexibledietinglifestyle @_aussiefitness @laurenfitfoodie @stealth_health_life www.skinnytaste.com www.ohsnapmacros.com www.lillieeatsandtells.com www.masonfit.com www.macrostax.com www.laurenfitfoodie.com www.jordosworld.com www.stayfitmom.com 0:00 Morning Routine 0:53 Let's Catch Up 1:56 Defending my Diagnosis 7:08 A New Chapter 10:42 Setting Goals 12:01 Never Enough 16:11 My Meal Plan 19:58 Groceries 20:28 Vyvanse Update 21:44 Weighing In Again

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Episode One of my experience with a GLP-1 medication (semaglutide) to address menopause-related weight gain and health challenges. At 56, I’ve struggled to lose weight post-menopause, despite years of healthy habits. My weight recently reached its highest, and my doctor expressed concerns about my health. By documenting my GLP-1 weight loss journey with Weight Watchers, I hope to connect with others navigating similar struggles, particularly menopausal women, and share insights on health, fitness, and resilience. 👉 Don’t forget to SUBSCRIBE to get the latest on my GLP-1 weight loss journey. Have questions? Leave a comment below! 00:00 Intro and welcome 01:12 Weight loss struggles 02:48 Menopause effects 08:00 Hormone therapy 09:16 Weight loss struggles 10:08 Sedentary effects 14:00 GLP-1 decision 14:51 Weight Watchers 17:02 First GLP-1 dose #GLP1 #semaglutide #weightloss #menopause #weightwatchers #weightlossjourney

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