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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?
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Are you overweight and trying to lose fat… but every workout just leaves your knees hurting and motivation dropping? You're not alone-and this is the video you actually needed on Day 1. I am Viren, your certified fitness coach. In this video, I'm breaking down the 4 biggest exercise mistakes overweight beginners make-especially when they follow workouts meant for athletes or influencers. We're talking: ❌ Jumping exercises that destroy joints ❌ Daily HIIT that spikes inflammation ❌ Long cardio sessions that kill muscle ❌ Dangerous movements like lunges too early But more importantly: I'll show you exactly what to do instead. These beginner-friendly strength exercises will protect your knees, build your metabolism, and actually help you lose fat sustainably-without injury or burnout. Whether you're doing home workouts or planning to hit the gym-this is your no-BS guide to start your journey safely and smartly. #lowimpactcardio #overweight Tags how to lose weight safely 2025 why am i overweight when i eat healthy and exercise exercise when overweight workouts for obese beginners at home exercise to lose weight for obese overweight workout beginner workout to loose belly fat workout to loose love handles low impact workout beginner workout for obese overweight beginner workout at home fat loss without cardio safe workout for plus size beginners no jumping workout for obese strength training for overweight beginners fat loss exercise without injury exercise mistakes overweight
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Is Ozempic really the miracle drug it's touted to be? Are you ready for another no-BS breakdown of a health trend that's driving me absolutely crazy? In this video, I'm diving deep into Ozempic - the "miracle" weight loss drug that's got everyone talking. I'm exposing the dark side of this pharmaceutical quick fix and explaining why losing weight isn't about a magic injection, but about understanding your body, building muscle, and making sustainable lifestyle changes. I'll be breaking down the science, revealing the shocking side effects Big Pharma doesn't want you to know about, and giving you REAL alternatives to achieve your health goals. If you're tired of being sold false promises and want to understand what's REALLY happening when you inject this drug, this video is for you. 💜 ALL MY LINKS HERE: https://linktr.ee/shelleydarlington 💜 BUY MY STRONG CURVES COOKBOOK: https://dub.link/strong-curves-cookbook 💜 JOIN MY STRONG CURVES WEB APP: https://dub.link/strong-curves-app 💜 BUY MY STRONG CURVES EBOOKS: https://dub.link/ebooks 💜 BUY STRONG CURVES WORKOUT EQUIPMENT: https://dub.link/workout-equipment 💜 BUY BOOTY BANDS ON AMAZON: https://dub.link/booty-bands 💜 BUY CABLE ANKLE STRAPS ON AMAZON: https://dub.link/ankle-straps 💜 BUY BARBELL PAD ON AMAZON: https://dub.link/barbell-pad 💜 BUY FABRIC HIP BANDS ON AMAZON: https://dub.link/fabric-hip-bands Stay Strong Love Shell x Instagram: https://www.instagram.com/shelleydarlington/?hl=en Tiktok: https://www.tiktok.com/@shelleydarlington?lang=en **Disclaimer:** Any workout routines and exercises, or nutritional advice presented in this video are intended for informational and educational purposes only and are not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult with your physician or other qualified health care provider before beginning any new exercise or diet program. By participating in any workouts, you agree that you do so at your own risk, are voluntarily participating in these activities, assume all risk of injury to yourself, and agree to release and discharge Shelley Darlington from any and all claims or causes of action, known or unknown, arising out of Shelley Darlington Channel's content. Remember to listen to your body and take breaks as needed. If you experience any pain or discomfort, stop the exercise immediately and seek professional medical advice. Stay safe and enjoy your workout!
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#shorts YOUR CHEAT SHEET: https://coachingcheatsheet.com/optin-460785161611114819997 More resources: Join the Nutrition Coaching Secrets FB group: www.facebook.com/groups/nutritioncoachingsecrets/ Watch this video next: https://youtu.be/WSQXo8dZXho See you in the next video! FAQs: How To Build A Nutrition Coaching Business: https://youtu.be/WSQXo8dZXho How To Get More Nutrition Coaching Clients: https://youtu.be/Kag6LW7O9JU How To Get Your Nutrition Clients Better Results: https://youtu.be/KFSr7W8BvWk Is Body Recmposition Possible? : https://youtu.be/h6Y32-vQoAQ Should Your Clients Track Macros: https://youtu.be/3BBCLEKPU40 How To Deal With Noncompliant Clients: https://youtu.be/w4jtEbwofVo #nutritioncoaching #nutritioncoach #jasonphillips
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"4 Must-Try Drinks for a Perfect Breakfast! 🥤✨ Boost Energy & Metabolism" Description: Start your day right with these 4 must-try drinks for a perfect breakfast! 🥑🍋 Whether you’re looking to boost your metabolism, stay energized, or feel full longer, these drinks have got you covered. Plus, if you want all these benefits in one, Lean Bliss is a game-changer! Check it out in the bio or comments. 💪 Timestamps: 0:00 Intro 0:05 Lemon Water 🍋 — Hydrates & boosts metabolism 0:15 Green Smoothie 🥬 — Packed with nutrients for energy 0:25 Chia Drink 🌱 — Rich in fiber, keeps you full 0:35 Proffee ☕ — Coffee + protein for a power boost 0:45 Lean Bliss — All these benefits in one! Tags: #BreakfastDrinks #HealthyMorning #MetabolismBoost #MorningRoutine #HealthyLiving #WeightLossTips #EnergyBoost #LeanBliss #HealthyHabits #PerfectBreakfast
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Hello, I am Jaeho, a trainer and physical therapist. Today's routine is a mix of abs and lower body exercises that you can do standing up. It may be more suitable for aerobic exercise. For those who find it difficult to straighten your legs and raise them, I recommend modifying it by bending your knees and lifting them. I always recommend that you perform exercises that are appropriate for your physical strength level. 안녕하세요 트레이너이자 물리치료사 재호입니다. 오늘은 서서 할 수 있는 복근 운동과 하체 운동이 혼합된 루틴입니다. 유산소 운동에 좀 더 적합할 수 있습니다. 다리를 곧게 펴고 드는 동작이 힘드신 분들은 무릎을 구부려서 올리는 방법으로 변형하시는 것을 권장해드립니다. 항상 본인의 체력 수준에 맞춰서 운동을 진행하실 것을 권장해드립니다. 00:00 intro 00:05 Round 1 05:06 Round 2 10:06 Rest 10:12 Round 3 15:13 Round 4
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Alternate Day Diet (ADF) by Gary who is determined to Learn How To Lose Weight Fast Using Intermittent Fasting. This is day 27 of my alternate day fasting programme, so I weighed in the morning 79.1 and then the day modes and food looks good at 4 and 4.5. I believe in self monitoring is the way to reflect on the diet. I was contemplating why I lost so much weight on day 25 I lost 1.5 KGS. Next after loosing weight consecutively I dropped there. Looking at my diary I found out that I went to the gym, I went to the sauna the night before for about 25 minutes. My learning was water, since the body contains a lot of water sauna makes you sweat it out. For extreme weight loss go into a sauna! Also reflecting on modes on my fasting days, I will be taking 4 litres of water to make sure I am more hydrated.So that's my update. Thank you and watch my other videos to see if intermittent fasting works.
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