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Metformin is a commonly prescribed diabetes drug, but it is also popular among biohackers and life extensionists who take it for what they believe to be its longevity benefits. While this use is still being investigated, new studies indicate that taking metformin may have some drawbacks, including a new study indicating metformin decreases the gains in respiratory performance brought on by exercise. Previous studies have shown that respiratory fitness, as defined by an increase in VO2max, may have an impact in preventing hyperglycemia and type 2 diabetes, although the associated weight loss is also likely to contribute. The researchers of this study sought to determine if metformin impairs gains in VO2max the way it impairs muscle growth, as has been suggested by previous studies. This study focused on the people most likely to be taking metformin: people with metabolic syndrome. A total of 72 overweight or obese men and women with an average age of 53 were separated based on whether they were taking metformin or not. 63 of these people were able to complete 16 weeks of high-intensity interval training, which focuses on exercise sessions that maximize heart rate in order to increase cardiovascular and respiratory performance. Metabolic syndrome, respiration, and blood glucose were among the biomarkers assessed. However, this was not a placebo-controlled study, and the baseline characteristics of the two groups were different. Both groups were positively affected in every measurement of VO2max, but the researchers' hypothesis was correct: the improvements brought on by the exercise in this respect were significantly blunted in people taking metformin. While there was no significant difference in baseline measurements, the people who did not take metformin had better respiratory performance than the people who did. Regardless of these results, it may be unwise to cease taking metformin if you were prescribed it by your doctor. As an inhibitor of blood glucose, metformin is prescribed for reasons that often outweigh the concerns raised in this study - but you should certainly ask your doctor any questions you may have. But this study does illustrate a potential issue with metformin, particularly when it comes to people who would use it to augment their health, rather than to treat an existing condition. Previous studies do show that at least some cohorts do not experience reduced mortality. However, many believe that this drug is still worth exploring as a longevity drug. I am very much looking forward to the results of this study, and it should answer many lingering questions that we currently have. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Effects of chronic metformin treatment on training adaptations in men and women with hyperglycemia: A prospective study - https://onlinelibrary.wiley.com/doi/10.1002/oby.23410 Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study - https://diabetesjournals.org/care/article-abstract/44/12/2775/138471/Effect-of-Metformin-and-Lifestyle-Interventions-on Targeting Aging with Metformin (TAME) Trial - https://www.afar.org/tame-trial FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Robbie M / Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer & Editor - Ryan O’Shea Writer - Josh Conway Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #Metformin #Exercise #Longevity

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Click here to kickstart your fat loss journey with a customized fitness plan— try it free for 2 weeks: https://bws.plus/_a Tons of fitness videos promise the secret to fast fat loss... Then hit you with a “fat loss workout” that’d make a Navy SEAL throw up, a “fat loss diet” that repeatedly calls for boiled chicken for lunch… and lots of crying. If you’re not suffering, it’s not working. But what if I told you a simple walking method can help you lose fat faster than killing yourself with cardio? I know that sounds hard to believe, but it’s just one of four science-backed fat loss strategies I’ll show you to help you lose fat up to 2x faster—without losing muscle. And I’ve crunched the numbers to prove it. 0:00 - 0:30 : Why Most Fat Loss Plans Fail 0:30 - 4:04 : Adjusting Fat Intake 4:05 - 7:30 : The Walking Method 7:31 - 11:06 : The Accidental Deficit 11:07 - 13:37 : Unique Foods For Fat Loss 13:38 : What Results To Expect The first fat loss strategy is adjusting your fat intake. For health reasons you don’t want to go below around 35 to 50 grams of fat per day. Here's what I want you to do: Think about the fats you eat everyday. Cheese, butter, and even healthy fats like avocado. Starting tomorrow, cut however much you usually have of these in half. I want you to also check if you’re eating any high fat proteins. Try having just one of these daily, then for all your other meals, choose a more pure protein source from this list. And you can apply this same concept even when you’re eating out. If you just cut 1 fat source in half and make 1 protein swap, boom you’re saving up to 250 calories per day, which already speeds up your fat loss by half a pound per week. And you can lose even more by combining it with the next strategy, the walking method. What most people don’t know is that instead of relying on a specific “fat loss workout”, a highly active person can burn up to 2,000 more calories daily just from NEAT compared to someone who's sedentary. While cardio is great for your heart and health, it’s kind of just “meh” for fat loss. A much better approach I personally use myself and with our Built With Science clients is plain old walking. Now I’ve set a goal in my Built With Science app to hit 10,000 steps a day and it keeps track of it for me. But you can use the health app on your phone, and just aim for anywhere between 7,000 to 12,000 steps a day. But 30 minutes of walking is already 3,000 steps and for the average person can burn anywhere from 100 to 200 calories. Do that simple 30 minute walk every day and after a month you’ll lose an extra pound of fat, or an extra quarter pound of fat per week. And you can speed this up even faster with a dieting strategy I call the accidental deficit. During your busiest days, rely on quick grab-and-go protein sources and ready to eat fruits. Then when you finally get home, have a big dinner of lean protein and vegetables instead of ordering takeout. Then, just go to bed before you start snacking. If you do this right, you could end your day eating as little as 1,300 to 1,600 calories. For most people this is a huge deficit and is why I do NOT recommend doing this “fat loss diet” more than once or twice a week max - and preferably on your rest days. But even just doing this once a week can increase your average daily calorie deficit by about 100 calories, and help you get rid of an extra quarter pound per week. But this will work even better if you combine it with the last strategy for fast fat loss - eating foods that do the work for you. Most people don’t know this but your body burns a certain amount of calories just from digesting food. And protein is special because a solid 20 to 30% of its calories immediately get burned up for digestion, absorption, and metabolism - which is more than double any other food. As a result, studies have shown going from a low-protein to a high-protein diet can raise your daily calorie burn by 4–5%. For a 2000 calorie diet, that’s an extra 90–100 calories burned per day. It may not sound like much, but that’s like doing a 10 minute jog everyday, and can add up to a pound of fat loss every month. Not to mention all the muscle building benefits this has as well. So take your bodyweight in lbs and multiply it by 0.8. If you’re not getting anywhere near that, then bump up how much protein you have in each meal to get closer to that target. And if you’re already hitting that, great, focus on swapping your processed foods for whole foods high in fiber and resistant starch. Put all 4 strategies together, and even being conservative with the numbers, you're looking at an extra 1.2 pounds of fat loss per week. That’s over twice what most people manage on a typical diet.

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Metformin and Weight Loss: What Science Really Says Losing weight can be frustrating, and with so much conflicting advice, it’s hard to know what works. Many wonder if Metformin helps with weight loss, but is it a real solution or just a side effect? In this video, we’ll break down the science behind Metformin and weight loss, how it affects insulin resistance, appetite, and fat storage, and whether it’s an effective tool for non-diabetics. 🔹 Does Metformin help you lose weight? 🔹 How does Metformin affect appetite and metabolism? 🔹 Why do some people lose weight on Metformin while others don’t? 🔹 Is Metformin safe for non-diabetics? If you're considering Metformin for weight loss, it's important to understand its real effects, possible side effects, and the role of diet and exercise. Stick around to the end as we also discuss whether Metformin is better than Ozempic for weight loss! 💬 Have you taken Metformin? Did it affect your weight? Let us know in the comments! 🔔 Subscribe to Pharmacist Online so you don’t miss our next video: Metformin vs. Ozempic—Which is better for weight loss? 👉 Always consult your doctor before starting or stopping any medication. This video is for informational purposes only and should not replace professional medical advice. #Metformin #WeightLoss #MetforminForWeightLoss #Diabetes #PCOS #MetforminSideEffects #WeightLossTips #BloodSugar #InsulinResistance #Health ●▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬● Join our community and stay updated on the latest insights from the world of pharmacy. Follow us on Facebook || https://www.facebook.com/profile.php?id=61568805538644 ||and TikTok|| https://www.tiktok.com/@pharmacistonline_0|| for even more health tips, updates, and expert advice. Together, let's work towards better understanding and smarter healthcare decisions. ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ 👍Like the video (it's quite helpful!) 💬 Leave a comment below to let us know what you think! 🔗 Share the video with anyone you think might help ▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬▬ 🎬SUGGESTED VIDEOS Don't forget to watch other videos. Please check them out : https://youtu.be/AMNlkvd4krY https://youtu.be/7dKyUA3FXO4 https://youtu.be/j5Qg2gDIENg https://youtu.be/3QJgXkRmB5k Disclaimer Fair Use: 1. The videos have no negative impact on the original works. 2. The videos we make are used for Entertainment purposes. 4. We use only the audio component and tiny pieces of video footage, only if it's necessary. DISCLAIMER: Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education, and research. Fair use is a use permitted by copyright statutes that might otherwise be infringing.

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Fox News Julie Banderas Weight Loss Transformation In this video, we dive into Fox News anchor Julie Banderas' incredible weight loss journey. At 50 years old, Julie lost an impressive 30 pounds by making changes to her lifestyle, focusing on diet, exercise, and a positive mindset. Here's how she did it: 👉High-protein meals with fruits, vegetables, lean proteins, and whole grains | Cut out processed foods and sugary snacks, etc. 👉Intense workouts 5 days a week | Cardio, including running, to burn calories and improve heart health | Weightlifting to build muscle and boost metabolism 👉 Controlled portions with balanced carbs, proteins, and healthy fats 👉 Set achievable goals and celebrate small victories Watch Out: Christina Aguilera Weight Loss - https://youtu.be/YM-SpeajbVg Keywords: Julie Banderas Weight Loss, Julie Banderas, Fox News Julie Banderas Weight Loss, How Did Julie Banderas Lose Weight, Julie Banderas Weight Loss Before And After, Weight Loss, How To Weight Loss Fast, Weight Loss Diet, Did Julie Banderas Lose Weight, Julie Banderas Diet and Exercise, Julie Banderas Weight, All images, logos, and brand names in this video are used under the Fair Use doctrine, as outlined in Section 107 of the Copyright Act 1976, for educational and review purposes such as criticism, commentary, news reporting, teaching, and research.