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Drs Akshay Jain and Lorenzo Leggio discuss GLP-1 RA therapy and its potential to mitigate alcohol misuse syndrome. https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt --TRANSCRIPT-- Akshay B. Jain, MD: Today we are very excited to have Dr Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Jain: We'll get right into this. Your session was, in my mind, extremely informative. The session looked at glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy and its potential effects on mitigating alcohol misuse syndrome, so, reduction of alcohol addiction potentially. We've seen in some previous clinical trials, including many from your group, that alcohol use is known to be reduced — the overall risk of incidence, as well as recurrence of alcohol use — in individuals who are on GLP-1 RA therapy. Can you share more insights about the data already out there? Leggio: At the preclinical level, we have a very robust line of studies, experiments, and publications looking at the effect of GLP-1 RAs, starting from exenatide up to, more recently, semaglutide. They show that these GLP-1 RAs do reduce alcohol drinking. They used different animal models of excessive alcohol drinking, using different species — for example, mice, rats, nonhuman primates — models that reflect the excessive alcohol drinking behavior that we see in patients, like physical alcohol dependence or binge-like alcohol drinking, and other behaviors in animal models that reflect the human condition. In addition to that, we recently have seen an increase in human evidence that GLP-1 RAs may reduce alcohol drinking. For example, there is some anecdotal evidence and some analyses using social media showing that people on GLP-1 RAs report drinking less alcohol. There are also some pharmacoepidemiology studies which are very intriguing and quite promising. In this case, people have been looking at electronic medical records; they have used the pharmacoepidemiology approaches to match patients on GLP-1 RAs because of diabetes or obesity, and have compared and matched to patients on different drugs as the controls. A study was recently published in Nature Communications by a group in Cleveland in collaboration with Dr Nora Volkow from the National Institute on Drug Abuse. This study shows the association between being on a GLP-1 RA and the lower incidence of alcohol use disorder and lower drinking. There is also some promise from prospective randomized clinical trials. In particular, there was one clinical trial from Denmark, a well-known and -conducted clinical trial where they looked at exenatide, and they didn't see an effect of exenatide compared with placebo in the main analysis. But in a subanalysis, they did see that exenatide reduced alcohol drinking, but only in patients with alcohol use disorder and obesity. This suggests that these medications may work for some patients and not for other patients. That's fine, because just like in any other field in medicine, including diabetes, obesity, hypertension, Parkinson's, and depression, not all medications work for everybody. If these medications will work for alcohol addiction, we do not expect that they will work for everybody. One ongoing question in the field is to try to identify the phenotypes or the subgroup of people who may be more responsive to these medications. Jain: This is such a fascinating field, and all these studies are coming out. In your review of all the literature so far, do you think this is dose dependent? Also, we see that, for instance, with certain individuals, when they take GLP-1 RA therapy, they might have a lot of gastrointestinal (GI) side effects. Recent studies have shown that the rate of these GI side effects does not necessarily correlate with the amount of weight loss. In the alcohol addiction field, do you think that the GI side effects, things like nausea, could also have a potential role in mitigating the alcohol addiction? Leggio: This is a great question. They may play a role; they may contribute, too, but we don't think that they are the driving mechanism of why people drink less, for at least a couple of reasons. One is that, similar to the obesity field, the data we have so far don't necessarily show a relationship between the GI side effects and the reduction in drinking. Plus, the reduction in drinking is likely to happen later when many GI side effects are gone or attenuated. Transcript in its entirety can be found by clicking here: https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt
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Maximum Keto Gummies appeared on Shark Tank, sparking interest in these innovative keto-friendly gummy snacks. The entrepreneurs behind Maximum Keto Gummies presented their product as a guilt-free treat for those following a ketogenic diet. With promises of delicious flavor and low carb content, the Sharks were intrigued. However, as with any Shark Tank pitch, the success of Maximum Keto Gummies was far from guaranteed.
Initial Excitement
When Maximum Keto Gummies made their entrance onto the Shark Tank stage, they immediately caught the attention of the investors. The vibrant packaging and enticing flavors drew the Sharks in, and they were eager to learn more about this unique product. The entrepreneurs behind Maximum Keto Gummies confidently explained the benefits of their gummies, emphasizing their low sugar and high fat content that aligns with the principles of a ketogenic diet. The Sharks were impressed by the market research presented and saw the potential for Maximum Keto Gummies to fill a niche in the health food industry.
However, as the pitch continued, questions arose about the scalability of the business and the feasibility of producing the gummies on a larger scale. The Sharks raised concerns about the cost of ingredients, the complexity of manufacturing, and the competitive landscape of the health food market. While the entrepreneurs had a strong vision for Maximum Keto Gummies, they struggled to convince the Sharks that their product could achieve widespread success.
Challenges and Negotiations
As the Sharks delved deeper into the financials of Maximum Keto Gummies, it became clear that the business faced significant challenges. The high production costs, limited distribution channels, and intense competition posed obstacles to the growth of the brand. Despite these hurdles, the entrepreneurs remained optimistic and sought guidance from the Sharks on how to overcome these challenges.
Negotiations ensued as the Sharks debated the valuation of Maximum Keto Gummies and the potential for a partnership. Some investors expressed interest in the product but were hesitant to make a deal due to the uncertainty surrounding the business model. Others saw the potential for growth and were willing to take a risk on the entrepreneurs. In the end, a deal was struck that would provide the funding and mentorship needed to help Maximum Keto Gummies thrive in the competitive health food market.
Post-Shark Tank Success
After appearing on Shark Tank, Maximum Keto Gummies experienced a surge in popularity as viewers became intrigued by the product. The exposure from the show led to increased sales and brand recognition, propelling Maximum Keto Gummies to new heights. The entrepreneurs used the investment from the Sharks to expand their product line, improve their manufacturing process, and secure partnerships with retailers nationwide.
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With the support of the Sharks, Maximum Keto Gummies was able to overcome the challenges highlighted during their pitch and establish themselves as a leading player in the health food industry. The success of Maximum Keto Gummies serves as a testament to the power of entrepreneurship, innovation, and perseverance in the face of adversity.
Conclusion
In conclusion, the journey of Maximum Keto Gummies on Shark Tank was a rollercoaster of highs and lows. From the initial excitement of the pitch to the challenges faced during negotiations, Maximum Keto Gummies weathered the storm and emerged stronger than ever. The post-Shark Tank success of Maximum Keto Gummies is a testament to the resilience of the entrepreneurs behind the brand and the power of a great idea backed by strategic partnerships. As Maximum Keto Gummies continues to grow and evolve, it serves as a reminder that with determination and vision, anything is possible in the world of business.
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Take our quick 3 minute survey to see if one of our programs might be right for you by visiting - https://BrandNUEplan.com Weight loss products based on science - https://brandnueweightloss.com/shop In this video we discuss the top 3 natural supplements that have been scientifically proven to stimulate GLP-1 production in the human body. Green coffee bean extract (chlorogenic acid) stimulates GLP-1. Rhodiola stimulates GLP-1. Glutamine stimulates GLP-1 0:00 - Intro 2:40 - Green Coffee Bean 3:38 - Rhodiola 4:07 - Glutamine https://www.mdpi.com/1660-4601/19/19/12117#:~:text=Eight%20weeks%20of%20regular%20green,with%20abdominal%20obesity%20%5B6%5D. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.693048/full https://pubmed.ncbi.nlm.nih.gov/15365617/#:~:text=Glutamine%20potently%20stimulates%20glucagon%2Dlike%20peptide%2D1%20secretion%20from%20GLUTag%20cells https://pmc.ncbi.nlm.nih.gov/articles/PMC7517657/ Media or marketing contact - [email protected] DISCLAIMER: The advice provided is Dr. Nuesse's opinion and meant to be used by patients under the care of a physician. Dr. Nuesse is a licenced chiropractor in Ohio. His use of the term "doctor' and "Dr." only refer to his degree. The information in this video is not intended to diagnose or treat any medical condition. Please consult with a medical professional about your personal health needs before changing any exercise, dietary, or nutritional regimen. Dr. Nuesse is an Amazon affiliate and earns money from Amazon Learn More; https://brandnueweightloss.com/ http://www.matthewnuesse.com/ https://www.learnoursecret.com/ https://www.facebook.com/brandnueweightloss/
