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In this week’s episode, Dr. Mary and Dr. Lucy continue their exploration into the world of supplements. The spotlight is on the fascinating compound Berberine—a natural supplement that’s gaining widespread attention for its potential to improve insulin resistance, support cholesterol management, and enhance overall metabolic health. Listeners will gain a deeper understanding of how Berberine works, its science-backed benefits, and practical tips for incorporating it into a health-focused lifestyle. Berberine Overview ✨ Origin: A bioactive compound extracted from various plants, particularly the barberry plant, used in traditional Chinese and Ayurvedic medicine for centuries. ✨ Mechanism of Action: Activates the AMPK pathway, a critical regulator of cellular energy metabolism, improving how the body processes and utilises energy. ✨ Modern Interest: Recently studied for its effects on metabolic health, including insulin resistance, type 2 diabetes, obesity, and cardiovascular health. Key Benefits ✨ Improved Insulin Sensitivity: 📍Enhances glucose uptake into cells and improves insulin signalling. 📍Similar to the effects of metformin. 📍Supports better blood sugar control and energy utilisation. ✨ Anti-Inflammatory Effects: 📍Reduces inflammation by inhibiting inflammatory pathways and cytokines. 📍Breaks the cycle of insulin resistance and inflammation. ✨ Cholesterol Management: 📍Lowers LDL cholesterol by inhibiting PCSK9 enzymes. 📍Promotes better cholesterol recycling and utilisation. ✨ Gut Microbiome Health: 📍Encourages growth of beneficial gut bacteria, similar to metformin. 📍Influences metabolic health positively via gut microbiome changes. ✨ Liver and Muscle Benefits: 📍Helps the liver process glucose more effectively. 📍Improves glucose utilisation in muscle cells. ✨ Polycystic Ovarian Syndrome (PCOS): 📍Improves ovulation by enhancing insulin sensitivity in ovaries. 📍Potentially aids fertility when combined with other ovulation-inducing medications. Safety and Considerations ✨ Side Effects: 📍Common issues: Diarrhea, constipation, and stomach cramps. 📍Shares similar gastrointestinal effects with metformin. ✨Interactions with Medications: 📍Metabolised via the CYP450 liver enzyme system. 📍Potential interactions with other medications processed by the same pathway. 📍Caution for those on glucose-lowering drugs due to potential low blood sugar risks. ✨ Pregnancy and Breastfeeding: 📍Lack of safety data for use during pregnancy or breastfeeding. 📍Should not be used due to potential risks to the fetus or baby. ✨ Illness and Stopping Use: 📍Like metformin, berberine might need to be stopped temporarily during significant illness to avoid complications like acidosis. ✨Product Quality: 📍Supplements vary widely in quality. 📍Avoid products with additives like maltodextrin, sunflower oil, or high alcohol content. 📍Choose supplements with minimal, clean ingredients. ✨ General Recommendations 📍Treat berberine like a medication: targeted, monitored, and with medical supervision. 📍Take it with food for the best absorption. 📍Not a standalone solution: Combine with lifestyle changes for best results. 📍Avoid excessive or unmonitored use to prevent potential risks. ✨ Final Verdict 💃 Cautious Yay: Promising benefits backed by solid evidence for improving insulin resistance and metabolic health. 💃 Supervision Advised: Should be used thoughtfully, particularly if combined with other medications or for specific conditions like PCOS or diabetes.

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Understanding GLP-1 Weight Loss with Dr. Alexandra Sowa | The Down Size In this episode of The Downsized, host Laraine Durham welcomes Dr. Alexandra Sowa, who has successfully lost over 50 pounds on tirzepatide. Dr. Sowa is a clinical instructor at the NYU School of Medicine with over 10 years of experience in obesity medicine. She joins the discussion to shed light on the biology of obesity and the role of GLP-1 medications, such as Ozempic, Mounjaro, and Zepbound. Dr. Sowa shares insights from her new book, 'The Ozempic Revolution,' which offers a comprehensive look at GLP-1 medications and the SoWell method for long-term success. This episode covers the benefits of these drugs beyond weight loss and the importance of a holistic approach, including diet, strength training, and mental health. Laraine and Dr. Sowa also discuss the stigmas surrounding weight loss medications and the importance of dispelling myths. The episode is a must-watch for anyone interested in understanding GLP-1 medications and their role in weight management. Make sure to like, comment, and subscribe! BUY THE OZEMPIC REVOLUTION: https://amzn.to/3DUP8QF DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Welcome to The DownSized 00:19 Introducing Dr. Alexandra Sowa 01:36 Dr. Sowa's Background and Practice 03:06 The Journey into Obesity Medicine 10:03 The Ozempic Revolution Book 14:01 Foundations of Weight Management 16:57 Core Tenets of Food Foundations 22:32 Protein Intake and Muscle Maintenance 24:00 Challenges of High Protein Diets 24:38 Strength Training and Physical Therapy 29:49 Mental Aspects of Weight Loss 36:05 Navigating Weight Loss Stigmas 36:41 Maintenance and Medication Dosage 43:40 Final Thoughts and Book Promotion

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📄 Description: Five high-impact trials from #ADA2025 — broken down fast by Drs Amrit Lamba, Amar Puttanna, and Patrick Holmes. We cover: • ACHIEVE-1: Oral GLP-1 for T2D. Is this the one for the "masses?" • BELIEVE & COURAGE: Muscle-preserving therapy to augment GLP-1 and more • REDEFINE-1 & -2: CagriSema - Semaglutide lus Amylin Agonist (cagrilintide) for Obesity and T2D • REAL WOLD DATA: Tirzepatide in type 1 diabetes (correction SURPASS-T1D although completed isn't being presented at the ADA) • Wildcard: Gene therapy enters the metabolic arena Quick, punchy insights in under 9 minutes — perfect for busy clinicians, educators, and researchers. 🧠 For more breakdowns, follow @GoggleDocs on LinkedIn, Twitter, and YouTube 🔗 Links to full trial references in the comments #Diabetes #Obesity #GLP1 #GIP #T1D #Cardiometabolic #MedicalEducation #ADA2025 #GoggleDocs #t2d

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Here’s Why Your Cardio Isn’t Burning Body Fat 😬❌ This is the biggest fat burning misconception: You think jogging on the treadmill as long as you can will burn fat. This isn’t actually doing anything because you’re not burning the right amount of energy. You’re also putting too much stress on your body. Think about it: the best Olympic runners out there are burning fat but they’re also burning muscle. They look frail and weak. The people who look strong and muscular are the sprinters 👀 So what you want to do is try to be like the sprinter. This means you do more HIIT training, which stands for High Intensity Interval Training. You can do 30 seconds at top speed sprinting then 30 seconds rest. If you want help burning fat, comment “EASY CARDIO” and I’ll help you out!

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Whilst maintaining a good diet and regularly exercising can help manage and control belly fat, stubborn areas such as the lower belly can prove difficult to eradicate. ➡️ Using fat dissolving injections for stubborn belly fat, Eva uses Celluform fat dissolving injections on a client's abdomen. For stubborn pockets of fat that simply won’t shift, Celluform injections offer a long-term solution in the problem areas which bother you most. This is an excellent non-surgical treatment for people who maintain a healthy diet and exercise regime but who are still struggling to tone specific areas of the body, like the stomach and ‘double chin’ area. ➡️ How does it work? We start by numbing the skin to make the procedure as pain-free as possible and then inject at various points across your problem area. The fat-dissolving product works to break down the membranes of the fat cells beneath the skin, causing them to become unstable and eventually flush out via the lymphatic system. This ‘flushing’ process may take around 6-8 weeks, at which point you’ll be able to enjoy your results! Celluform Fat Dissolving Injections are designed for body contouring, not for weight loss. Learn how you may benefit from fat dissolving injections when you watch our latest procedure walkthrough. Want to know whether this treatment will work for you? 💰 Price List ➡️ https://www.vivaskinclinics.com/price... ✅ Book Your Treatment or Virtual Consultation Now ➡️ https://connect.pabau.com/bookings.ph... And get more information on our Website: 📲 https://www.vivaskinclinics.com/ Subscribe for more Videos of VIVA Skin Clinics using this Link ⤵️ https://www.youtube.com/c/VIVASkinCli... ******************** 🎬 Welcome to the Channel of VIVA Skin Clinics ✨ VIVA Skin Clinics was founded on the principle of alignment, not perfection. Our team of highly-trained aesthetic artists works to align our patient’s inner sense of self with their outer self. ➡️ Whether they are looking to plump, tighten, smooth, or define, we guide them on their journey to becoming their most confident self. When mapping out treatment plans for our patients, we take into account their lifestyle and daily habits, factors that affect their skin and health. It’s important that to take a bigger picture approach to aesthetics because great skin goes beyond isolated treatments and we want to deliver a truly bespoke experience tailored uniquely to the patient ✅ No two patients are the same, so no two treatments should be. We champion natural-looking, long-lasting results that strengthen personal wellbeing. Our goal is to enhance, not hide! ✨ ➡️ Don’t forget to subscribe to the Channel, hit the bell button, and never miss a video! 🛎 ******************** 🌟 Connect with VIVA Skin Clinics on Social Media: Facebook ➡️ https://www.facebook.com/VIVASkinClin... Instagram ➡️ https://www.instagram.com/vivaskincli... Twitter ➡️ https://twitter.com/vivaskinclinics And don’t forget to check out our Website: ▶️ https://www.vivaskinclinics.com/ 📍 Find Us 📍 London, Kent & Tunbridge Wells Clinics https://connect.pabau.com/bookings.ph... 📞 Call Us 📞 02037 332199 📧 Email Us 📧 [email protected] . [email protected] ******************** #FatDissolvingInjections #FatMeltingInjectons #VIVASkinClinics