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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?
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Weight Loss Journey: An Overview of Selena Gomez’s Transformation
In 2024, pop sensation and actress Selena Gomez has taken the spotlight not just for her music but for her remarkable transformation. Over the past year, she has lost 30 pounds, a journey that has resonated with many of her fans and followers. Selena Gomez’s weight loss is particularly noteworthy because she achieved it without resorting to fad diets or extreme measures, focusing instead on sustainable lifestyle changes. This article explores how she achieved this significant weight loss, the methods she adopted, and the mindset that helped her along the way. To start, it is essential to understand the pressures that come with being in the public eye, especially for someone like Selena, who has faced considerable scrutiny regarding her body throughout her career.
Selena’s journey began with a desire to prioritize her health and well-being, moving away from the image-driven culture that often prevails in Hollywood. She aims to empower individuals by promoting a body-positive message and emphasizing the importance of mental health. As Gomez navigated through personal challenges, including battles with lupus and anxiety, she recognized the need for an approach that was both healthy and sustainable. This led her to embrace changes that would not only help her physically but also enhance her emotional and mental well-being.
In this comprehensive rundown of Selena Gomez’s 30-pound weight loss, we will delve into her approach to nutrition, exercise, self-care, and the mindset shifts that accompanied her transformation. The key to her success has been a balanced approach that fosters resilience and commitment rather than quick fixes. This reflection on her health journey serves as an inspiring reminder that lasting change is always within reach, provided one is willing to put in the effort and prioritize self-care above all else.
Nutritional Strategies for Sustainable Weight Loss
One of the cornerstones of Selena Gomez’s successful weight loss journey has been her commitment to nutritional changes that emphasize wholesome, nutrient-dense foods. She has publicly advocated for a balanced diet that focuses on whole foods, including plenty of fruits, vegetables, lean proteins, and healthy fats. Rather than adhering to the latest diet fad, Selena has embraced a lifestyle that enables her to enjoy her meals while still reaching her weight loss goals. This approach reflects a growing trend in the health and wellness community, where sustainability is prioritized over quick results.

Selena’s nutrition journey involved working with nutritionists to develop meal plans that cater to her specific needs, particularly as someone managing the effects of lupus. This meant being mindful of foods that could potentially trigger inflammation while ensuring she gets the vitamins and minerals necessary for her overall health. As a result, she began to cultivate a repertoire of recipes that align with her dietary preferences and health goals, proving that nutritious food can also be delicious. Cooking at home became a therapeutic exercise for Gomez, and she often shares her culinary creations on social media, encouraging her followers to try cooking as a wellness practice.
Moreover, Selena adopted the practice of mindful eating, a significant factor in her weight loss. This technique encourages individuals to focus on their meals, appreciate the flavors, and listen to their body’s hunger cues. By doing so, Gomez found that she could enjoy her favorite foods without guilt while also developing a healthier relationship with food. Mindful eating has not only aided in her weight loss; it has cultivated a newfound appreciation for nourishment and a holistic approach to her well-being.
The Fitness Regimen: Movement with Purpose
In conjunction with her dietary changes, Selena Gomez incorporated a regular fitness regimen that aligned with her lifestyle and personal preferences. Understanding that exercise should not be a punishment but rather an empowering activity, she focused on finding workouts that inspired and motivated her. This included a combination of strength training, cardio, and activities like dancing, which she loves. By integrating fun into her workouts, Gomez turned exercise into something she genuinely looks forward to, making it easier to stick to her routine.
Selena emphasized the importance of setting realistic fitness goals, avoiding rigorous training programs that could lead to burnout or injury. She began her fitness journey with manageable workouts, gradually increasing the intensity and duration as her body adapted. Furthermore, she made an effort to incorporate movement into her daily routine, such as walking her dog or taking dance classes, which not only helped with weight loss but also improved her mood and energy levels.
A notable aspect of Gomez’s fitness journey is her openness about the emotional benefits of exercise. She has shared how physical activity not only contributes to her weight loss but also serves as a crucial outlet for stress relief and mental clarity. By engaging in various forms of movement, she cultivated a habit that fosters both physical and mental health, reinforcing the idea that well-being is a holistic pursuit.
Mental Health and Self-Care Practices
Selena Gomez has long been an advocate for mental health awareness, and her weight loss journey is a testament to the importance of mental and emotional well-being in achieving health goals. Understanding that weight loss is not merely a physical challenge but also a psychological one, she made it a priority to address her mental health needs throughout the process. This included seeking therapy, practicing mindfulness, and engaging in self-care routines that bolster her emotional resilience.
Through her work with professionals, Gomez gained insight into managing pressure and anxiety, tools that proved invaluable in her weight loss journey. She learned to cultivate a positive mindset, focusing on self-love and acceptance rather than the scales. Instead of fixating on the number on the scale, she celebrated non-scale victories, such as increased energy levels, improved mood, and a sense of accomplishment in adhering to her health goals.
Furthermore, Selena leveraged her platform to emphasize the importance of self-compassion. She reminded her followers that everyone’s journey is unique and that it’s okay to have setbacks. By fostering a community of support, she encouraged open conversations about mental health and the challenges that accompany any lifestyle change. This approach not only solidified her connection with fans but also created an environment where individuals felt empowered to share their own stories of resilience.
Influence of Support Systems and Community
A critical element in Selena Gomez’s weight loss journey has been the support systems and community that surround her. Recognizing that changes in lifestyle can be daunting, she surrounded herself with positive influences, including family, friends, and fitness coaches, who provided encouragement and understanding throughout her transformation. This network served as a vital source of motivation, holding her accountable while reminding her of her goals.
Selena has often spoken about the significance of sharing her experiences with others, be it through social media or in her advocacy work. By being transparent about her struggles and triumphs, she has fostered a sense of community among her followers, many of whom embark on their personal health journeys. Selena’s candidness about her own challenges resonates with many individuals who face similar obstacles, creating an empowering atmosphere of shared experiences and mutual support.
Moreover, Gomez has engaged in various initiatives that promote health and wellness within her fanbase. By collaborating with wellness brands and participating in discussions about healthy living, she has used her platform to shine a light on the importance of community in health journeys. This communal aspect fosters resilience, reminding individuals that they are not alone in their struggles, which can make all the difference in sustained lifestyle changes.
Reflecting on the Journey: Empowerment and Learning
Selena Gomez’s journey of losing 30 pounds in 2024 has been about more than just physical transformation; it has been a profound experience of empowerment and self-discovery. From understanding the importance of nourishing her body with wholesome foods to embracing fitness and mental health practices, Gomez has made choices that align with her values and well-being. She exemplifies that true health is multifaceted, encompassing physical, emotional, and mental aspects.
Throughout her journey, Selena has learned to prioritize herself, making decisions that reflect her overall health. This shift has not only transformed her physical appearance but also fortified her spirit and passion for life. She has emerged more resilient, emphasizing the significance of self-love and authenticity in everything she does. By advocating for her mental health and sharing her journey, she has inspired countless individuals to embrace their paths with confidence and determination.
As Gomez continues to inspire through her artistry and activism, her narrative serves as proof that positive change is possible through steady dedication. Her journey encourages others to seek holistic approaches that prioritize well-being over superficial standards, fostering a culture that recognizes diversity in body shapes and sizes. In closing, Selena Gomez’s story is a powerful reminder that lasting change is achieved through sustainable practices, community support, and a commitment to self-care.
Frequently Asked Questions
Selena Gomez’s weight loss journey has sparked numerous questions from her fans and beyond. Many individuals are curious about the specifics of how she achieved her 30-pound loss in a healthy and sustainable manner. The questions range from inquiries about her diet regimen to her exercise routines, as well as tips for those seeking to make similar lifestyle changes. Understanding these nuances can help demystify her approach and support individuals on their personal wellness journeys.
Among the most frequently asked questions is regarding the specific dietary changes Selena made. As mentioned, she focuses on wholesome, nutrient-dense foods, steering clear of fad diets that promise quick results. Instead of strict calorie counting, she emphasizes moderation and balance, indulging occasionally while implementing healthier alternatives. Many fans wonder whether she follows any particular regimen, and while she has not adhered to one strict plan, her adaptability has been a cornerstone of her success. This flexibility allows her to enjoy food without feeling restricted, an essential aspect for anyone embarking on a health journey.
Exercise also comes into play, with questions about her specific routines and their effectiveness. Selena has incorporated regular workouts that suit her lifestyle and preferences, ensuring she finds joy in movement. This is crucial because enjoying the activity makes it sustainable. Many ask for possible recommendations on exercises to try. While everyone’s journey is unique, incorporating activities that are enjoyable and rewarding is key: whether through traditional gym workouts, dancing, or leisurely outdoor activities. Lastly, amidst the significant lifestyle changes, her mental health practices raise the question of how crucial they were to the process. Selena consistently emphasizes that mental wellness is intricately linked to overall health, encouraging her followers to prioritize mental self-care just as they would physical fitness. Tools such as mindfulness, therapy, and community support have played significant roles in shaping her current lifestyle.
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Lizzo shares her transformative health journey, revealing the meal plan that helped her achieve significant weight loss and improved wellness. Discover how she balanced her diet, managed GERD, and focused on whole, nourishing foods to drop her body fat by 16% and lower her BMI by 10.5 points since January 2023. Learn about her breakfast, lunch, and dinner routines, and how she prioritizes self-love and empowerment in her health journey. #Lizzo #WeightLoss #MealPlan #HealthJourney #BodyPositivity
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The Daily Cannon Show welcomes the epitome of Black Love with entrepreneurs and social media influencers Heather Sanders and T-Rell. With much talk surrounding Lizzo's weight loss journey, as she's transformed her life and health, TCD panel chops it about body positivity and shouts out all the beautiful women in entertainment who hold the BBW/plus-size crown. We also talk new music from Glorilla, the upcoming Jurassic Park reboot, and somehow the Drake vs. Kendrick Lamar beef topic is brought up AGAIN! Chapters: 00:00 - Intro 02:13 - First Up: Lizzo's Weight Loss 16:23 - What We Watching: Netflix's Last Supper, Jurassic Park Reboot 32:26 - New Music: Glorilla Shoots Her Shot At Duke Dennis on “ILBB2 (Remix)" 52:12 - Top 5 BBW's 1:17:21 - Outro #NickCannon #Lizzo #TheDailyCannon @NickCannon @BACKONFIGGG