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Gear, Growth, and Gains Ep. 014 Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths Show Time 32 min, 26 sec Show Notes and Description In episode 14 of "Gear Growth and Gains," Type-IIx discusses evidence-based practices in enhanced bodybuilding. He debunks myths about peptide reconstitution, emphasizing normal saline as the optimal solvent. The episode reviews emerging clinical data on combining GLP-1 agonists with myostatin inhibitors for improved muscle retention during weight loss. Type-IIx explains why oral 17 alpha-alkylated steroids pose greater cardiovascular risks than injectables due to their effects on lipid metabolism. Finally, he clarifies that excessive training volume impairs hypertrophy, stressing the importance of quality, intensity, and recovery for muscle growth. Outline and Timestamps Introduction and Episode Overview (00:00:30) Type-IIx introduces the podcast, outlines the four main topics, and provides disclaimers and promotional info. Peptide Reconstitution: Myths and Best Practices (00:02:56) Explains misconceptions about peptide reconstitution, debunks bro science, and emphasizes normal saline as the best solvent. History of Bro Science in Peptide Use (00:04:07) Describes the origins of peptide reconstitution myths in early bodybuilding forums and how misinformation spread. NAD+ and Solvent Confusion (00:06:33) Discusses the rise of NAD+ injections, their ineffectiveness, and confusion about which solvents to use. Normal Saline vs. Bacteriostatic Water (00:08:02) Clarifies why normal saline is preferred for reconstitution, and addresses misconceptions about bacteriostatic water. Properties and Safety of Normal Saline (00:09:05) Explains what normal saline is, its isotonic properties, and why it’s safe and widely used. Risks of Bacteriostatic Water and Solvent Regulation (00:10:24) Compares the risks of homemade bacteriostatic water to normal saline and explains regulatory reasons. GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32) Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab. Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38) Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions. Myostatin Inhibitors: Mechanisms and Trials (00:13:48) Reviews the history, mechanisms, and clinical trials of myostatin inhibitors, including new combination therapies with trevogrumab. COURAGE Trial Results and Drug Synergy (00:14:59) Details the COURAGE trial’s experimental groups, results, and the synergy of combining the myostatin inhibitor trevogrumab with GLP-1 drugs. Molecular Pathways in Muscle Growth (00:15:59) Explains the molecular signaling pathways involved in muscle growth and how different drugs interact. Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14) Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs. Oral Steroids and Cardiovascular Risk (00:17:31) Explains why 17 alpha-alkylated oral steroids like Anavar are more harmful to heart health than injectables. Mechanisms of Steroid-Induced Dyslipidemia (00:18:47) Describes how oral steroids negatively affect lipid profiles and increase cardiovascular risk. Estrogen’s Protective Role and Specific Steroid Effects (00:20:08) Covers the protective effects of estrogen on lipids and why certain steroids are harsher on the heart. Summary: Why Some Steroids Are Safer for Lipids (00:21:20) Summarizes why Dianabol is less harsh on lipids and why Trenbolone is still risky despite being injectable. Book Promotion: Bolus Guide (00:21:20) Promotes the Bolus guide for practical bodybuilding drug protocols and research interpretation. Bloodwork and Lab Testing Recommendations (00:23:07) Recommends Fitomics for blood work and explains how to sign up for lab testing and newsletters. Coach’s Corner: Training Volume Myths (00:24:10) Explains why more sets, reps, or sessions are not better for muscle growth and can be counterproductive. Mechanisms of Hypertrophy and Recovery (00:25:25) Discusses the science of muscle growth, the importance of recovery, and the difference between strength and size. Effective Reps and Optimal Training Volume (00:26:35) Emphasizes the importance of effective reps, diminishing returns of excessive volume, and the inverse dose-response curve. Conclusion and Outro (00:26:35) Wraps up the episode and promises more regular content in the future. Topics Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, peptide reconstitution, peptides, broscience, normal saline, GLP-1, trevogrumab, GLP-1 agonists, myostatin inhibitors, Courage trial, semaglutide, muscle retention, fat loss, oral steroids, cardiovascular risk, 17 alpha-alkylated steroid...
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Full episode on YouTube: https://www.youtube.com/watch?v=FT65D3Bd12k Spotify: https://open.spotify.com/episode/6tfGggZHtWqdX56COcC3UU?si=cD3s3BWMSwCNSLQitMacdg Apple: https://podcasts.apple.com/us/podcast/e136-sam-tejada-founder-of-liquivida-on-optimizing/id1682376664?i=1000713378262 This week, Roger welcomes Sam Tejada, the founder of Liquivida, a leading chain of wellness clinics. During the chat, Sam shares his transformative journey from being a firefighter to becoming a wellness expert and business owner. He also discusses the importance of holistic health approaches that incorporate free yet essential aspects like exercise, diet, and sleep, along with advanced therapies such as IV vitamin drips, NAD, and peptides. Sam emphasizes understanding your body through diagnostics such as comprehensive blood work and body composition analysis. Sam also covers the benefits of hormone optimization and offers insights into the impacts of toxins and the potential for industry shifts under the current federal health administration. Listeners will gain valuable information on improving their health, the importance of preventative care, and how to build successful wellness businesses. Sam shares from his book, “How to Win in Modern Wellness,” which provides further guidance and inspiration for those looking to make meaningful changes in the health sector. Topics Include: - Key Wellness Tips for Vitality - The Benefits of IV Therapy - The Role of Peptides in Fitness - GLP-1 Drugs and Weight Loss - The Impact of Toxins on Health Sam’s Book Recommendations: How To Win Friends And Influence People https://a.co/d/doTSHva Connect with Sam: Website https://samtejada.com/ Instagram https://www.instagram.com/sammy_tejada/?hl=en Book https://a.co/d/cLbdZEl Podcast https://podcast.samtejada.com/ LinkedIn https://www.linkedin.com/in/samtejada/ Liquivida https://www.liquivida.com/ X https://x.com/samaeltejada Let's Get Social: Connect with Roger and ThriveMore Brands https://linktr.ee/thrivemorewithrogermartin Check Out Roger’s Book: An Insider’s Guide to Business: Secrets From an Entrepreneur’s Playbook https://www.amazon.com/INSIDERS-GUIDE-BUSINESS-ENTREPRENEURS-PLAYBOOK/dp/B0CR7P8Z6R Visit Us: ThriveMore Brands Website https://thrivemorebrands.com/ Check Out Our Sponsor: RockBox Fitness is a state-of-the-art boutique fitness studio that combines confidence-building boxing and kickboxing with strengthening functional exercises. As the $96.7 billion fitness industry continues to grow, RockBox Fitness is in the perfect position to continue as a fast-growing, successful brand. If you’re looking to transform lives in your community, visit Rockbox Fitness http://rockboxfitness.com/franchise-opportunities for more information! ThriveMore Autopilot helps small and mid-sized business owners scale quickly without the struggle and headache. ThriveMore Autopilot https://thrivemore.ai/ is your strategic marketing and sales partner that rapidly grows your business by generating new leads, nurturing those leads, and booking those leads so they become long-term, paying customers. Produced By: Social Chameleon https://socialchameleon.us/
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Gesunde Ernährung ist ein wichtiger Bestandteil eines gesunden Lebensstils, insbesondere wenn es um Gewichtsabnahme geht. Wenn Sie abnehmen möchten, ist es entscheidend, die Grundlagen der Ernährung zu verstehen und zu befolgen. In diesem Artikel werden wir die Ernährungsgrundlagen zum Abnehmen besprechen, was Sie wissen müssen, um erfolgreich Gewicht zu verlieren und gesund zu bleiben.
1. Kalorienzufuhr und -verbrauch
Ein wichtiger Faktor beim Abnehmen ist das Verhältnis von Kalorienzufuhr zu Kalorienverbrauch. Um Gewicht zu verlieren, müssen Sie mehr Kalorien verbrennen, als Sie zu sich nehmen. Das bedeutet, dass eine ausgewogene Ernährung und regelmäßige körperliche Aktivität entscheidend sind. Achten Sie darauf, eine Kaloriendefizit zu erreichen, aber stellen Sie sicher, dass Sie immer noch genügend Nährstoffe zu sich nehmen.
Es ist wichtig zu beachten, dass nicht alle Kalorien gleich sind. Es ist besser, Nahrungsmittel zu sich zu nehmen, die reich an Nährstoffen sind, anstatt sich auf kalorienreiche, aber nährstoffarme Lebensmittel zu konzentrieren. Wählen Sie Lebensmittel wie Obst, Gemüse, Vollkornprodukte und mageres Eiweiß, um sicherzustellen, dass Sie alle notwendigen Nährstoffe erhalten, während Sie abnehmen.
Denken Sie daran, dass Ihre persönliche Kalorienzufuhr von verschiedenen Faktoren wie Geschlecht, Alter, Größe, Gewicht und Aktivitätsniveau abhängt. Es kann hilfreich sein, einen Ernährungsberater zu konsultieren, um herauszufinden, wie viele Kalorien Sie pro Tag zu sich nehmen sollten, um Ihre Gewichtsabnahmeziele zu erreichen.
2. Makronährstoffe und Mikronährstoffe
Die richtige Balance von Makronährstoffen – Kohlenhydraten, Proteinen und Fetten – ist entscheidend für eine gesunde Ernährung und Gewichtsabnahme. Kohlenhydrate sind eine wichtige Energiequelle, Proteine helfen beim Muskelaufbau und Fetten sind für die Aufnahme von fettlöslichen Vitaminen erforderlich. Stellen Sie sicher, dass Sie alle drei Makronährstoffe in Ihrer Ernährung haben, aber achten Sie auf die Qualität und Menge.
Zusätzlich zu Makronährstoffen sind Mikronährstoffe wie Vitamine und Mineralstoffe wichtig für viele Körperfunktionen. Essen Sie eine Vielzahl von Lebensmitteln, um sicherzustellen, dass Sie alle notwendigen Mikronährstoffe erhalten. Frisches Obst und Gemüse, Vollkornprodukte und mageres Fleisch sind gute Quellen für wichtige Mikronährstoffe.
Ein gesunder Ernährungsplan sollte auch ausreichend Ballaststoffe enthalten, um die Verdauung zu fördern und ein Sättigungsgefühl zu erzeugen. Ballaststoffreiche Lebensmittel wie Vollkornprodukte, Hülsenfrüchte und Gemüse sind wichtig für eine gesunde Gewichtsabnahme und allgemeine Gesundheit.
3. Essen in Maßen und regelmäßige Mahlzeiten
Ein häufiger Fehler beim Abnehmen ist das Überspringen von Mahlzeiten oder das Verzehr von sehr kleinen Portionen. Es ist wichtig, regelmäßig zu essen, um den Stoffwechsel anzukurbeln und Heißhungerattacken zu vermeiden. Planen Sie gesunde Mahlzeiten und Snacks ein, um sicherzustellen, dass Sie genug Energie haben, um den Tag zu bewältigen.
Essen Sie Ihre Mahlzeiten langsam und achten Sie auf Ihr Sättigungsgefühl. Hören Sie auf zu essen, wenn Sie sich fast satt fühlen, statt bis Sie voll sind. Dies hilft Ihnen, übermäßiges Essen zu vermeiden und die Kontrolle über Ihre Kalorienzufuhr zu behalten.
Denken Sie daran, dass es keine verbotenen Lebensmittel gibt. Es ist in Ordnung, gelegentlich etwas zu genießen, was Sie lieben, solange es in Maßen erfolgt. Eine ausgewogene Ernährung erlaubt Ihnen, Ihre Lieblingsspeisen zu genießen, während Sie dennoch Ihre Gewichtsabnahmeziele erreichen.
4. Hydratation und Flüssigkeitszufuhr
Die Flüssigkeitszufuhr spielt eine wichtige Rolle bei der Gewichtsabnahme. Trinken Sie ausreichend Wasser, um Ihren Körper hydratisiert zu halten und den Stoffwechsel zu unterstützen. Wasser kann auch helfen, das Sättigungsgefühl zu erhöhen und den Appetit zu kontrollieren, was Ihnen dabei helfen kann, weniger zu essen.
Vermeiden Sie zuckerhaltige Getränke wie Limonaden, Fruchtsäfte und Energydrinks, da sie viele leere Kalorien enthalten. Wählen Sie Wasser, ungesüßten Tee oder Kaffee als gesunde Getränkeoptionen. Sie können auch mit frischen Früchten oder Kräutern einen leckeren Geschmack verleihen, wenn Ihnen einfaches Wasser langweilig wird.
Achten Sie darauf, genug zu trinken, besonders vor den Mahlzeiten. Manchmal verwechseln wir Durst mit Hunger und essen unnötig mehr, wenn unser Körper eigentlich nach Flüssigkeit verlangt. Trinken Sie ein Glas Wasser, bevor Sie eine Mahlzeit zu sich nehmen, um sicherzustellen, dass Sie wirklich hungrig sind.
5. Bewusstes Essen und Achtsamkeit
Eine wichtige Ernährungsgrundlage zum Abnehmen ist bewusstes Essen und Achtsamkeit beim Genuss von Speisen. Nehmen Sie sich Zeit für Ihre Mahlzeiten und konzentrieren Sie sich auf das Essen. Vermeiden Sie Ablenkungen wie Fernsehen oder Handygebrauch während des Essens, um besser auf Ihr Sättigungsgefühl zu achten.
Üben Sie Portion Control, indem Sie kleinere Teller verwenden, um das Gefühl von Fülle zu erreichen. Hören Sie auf Ihren Körper und essen Sie nur so viel, wie Sie wirklich brauchen, nicht mehr und nicht weniger. Diese Achtsamkeitspraxis kann Ihnen helfen, Überessen zu vermeiden und bewusstere Entscheidungen über Ihre Ernährung zu treffen.
Denken Sie daran, dass Gewichtsabnahme ein Prozess ist, der Zeit und Geduld erfordert. Seien Sie geduldig mit sich selbst und feiern Sie kleine Erfolge auf Ihrem Weg. Mit einer gesunden Ernährung, regelmäßiger Bewegung und der richtigen mentalen Einstellung können Sie Ihre Gewichtsabnahmeziele erreichen und ein gesundes Leben führen.
Abschließend können Sie mit diesen Ernährungsgrundlagen zum Abnehmen die richtigen Schritte für Ihre Gewichtsabnahme setzen. Indem Sie auf Ihre Kalorienzufuhr achten, eine ausgewogene Ernährung mit Makro- und Mikronährstoffen anstreben, regelmäßige Mahlzeiten einplanen, ausreichend Flüssigkeit zu sich nehmen und bewusst essen, können Sie erfolgreich Gewicht verlieren und Ihre Gesundheit verbessern. Wenn Sie Fragen haben oder weitere Informationen benötigen, konsultieren Sie einen Ernährungsberater oder lassen Sie sich von Ihrem Arzt beraten. Machen Sie den ersten Schritt zu einem gesünderen Leben und beginnen Sie noch heute!
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Get My Book On Amazon: https://a.co/d/avbaV48 Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/ Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/ 👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/start-here 1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/ Book A Call With Me: https://hunterwilliamscall.carrd.co/ Supplement Sources: https://hunterwilliamssupplements.carrd.co/ Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY Socials: Instagram: https://www.instagram.com/hunterwilliamscoaching/ Podcast: https://hunterwilliamspodcast.buzzsprout.com/ Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/ In this video, I dive deep into the reasons behind the infamous “GLP plateau”—that frustrating point where fat loss on GLP-1 peptides like semaglutide, tirzepatide, and retatrutide comes to a grinding halt. I break down the physiological, hormonal, and lifestyle factors that drive plateaus, plus practical, science-backed solutions to get results moving again. If you’re struggling with stalled progress, this is the most comprehensive breakdown you’ll find on how to identify, understand, and push through GLP plateaus. Let’s break it all down step by step: ⸻ Timestamps 0:00 – Introduction: Why Do GLP-1 Plateaus Happen? 0:35 – Why Weight Loss Plateaus Are Universal 1:22 – How GLP-1s Work (Mechanisms: Semaglutide, Tirzepatide, Retatrutide) 2:36 – Typical Weight Loss Trajectory on GLP-1s 3:18 – When (and Why) Most People Plateau 4:55 – Plateau ≠ Failure: The New Weight Set Point 5:39 – Physiological & Metabolic Causes of Plateaus 6:26 – Resting Metabolic Rate Drop & Adaptive Thermogenesis 7:31 – Decreased Thermogenesis, Exercise Efficiency, & Mitochondria 8:42 – Muscle Loss and Its Impact on Plateaus 9:44 – NEAT (Non-Exercise Activity Thermogenesis) Drops 10:18 – Why the Body Adapts: Our Ancestral Survival Mechanism 11:06 – Hormonal Adaptations: Leptin, Ghrelin, Insulin 13:03 – Leptin Drop: Increased Hunger, Lower Metabolism 13:41 – Ghrelin Rise: Appetite Returns 15:17 – Insulin, Metabolic Health & Fat Loss 17:20 – Thyroid Hormones: T3, Metabolic Rate, and the Plateau 19:03 – Cortisol, Stress, and Fat Storage 20:07 – Sex Hormones: Testosterone, Fat Loss, and Plateaus 21:46 – Amylin, Neuropeptide Y, and Brain Pathways 22:44 – Behavioral & Lifestyle Factors: NEAT, Adherence, Calorie Creep 24:44 – Psychological Fatigue, Sleep, Diet Quality, & Hydration 28:27 – Is It a True Plateau? Body Fat vs. Weight Loss 28:32 – Pharmacological Tolerance & Dosing Issues 30:00 – Appetite Pathways and Receptor Desensitization 31:52 – Dose Ceiling: When More Isn’t Always Better 33:26 – Strategies to Break Through a Plateau 34:16 – Re-evaluating Diet: Macros, Sugar Diet, and Tracking 34:45 – Activity, Resistance Training, and NEAT 35:03 – Sleep, Stress, Thyroid, and Other Medications 35:44 – Add-On Pharmacology: LDN, Cagrilintide, Leptin Analogs 37:01 – Mitochondrial Pathways: BAM15, SLU-PP-332, Carnitine 37:50 – Cycling, Refeeds, and Metabolic Resensitization 39:55 – Fasting, Intermittent Fasting, and Nutrition 40:08 – Recap: Everyone Plateaus—How Will You Respond? 41:02 – Thank You & Outro
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Get Yours Here: https://get.aspr.app/SH1CSl I’ve partnered with The Body Firm to show that aging isn’t something to hide, it’s something to care for. Crépe Erase has made my skin visibly smoother, and I’m not looking back! #CrepeErase #BodyFirst #ad @CrepeEraseChannel - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 🖤 Let's Connect: TikTok: https://www.tiktok.com/@kellyrosesarno Instagram: https://www.instagram.com/kellyrosesarno Facebook: https://www.facebook.com/KRoseSarno Website: www.kellyrosesarno.com Mascara Spreadsheet (I've reviewed over 300!): https://bit.ly/3LL9n4a Blog: https://www.kellyrosesarno.com/blog ➤ For business inquiries only: [email protected] 🖤 DISCOUNT CODES - For all my codes, visit https://linktr.ee/kellyrosesarno Some links are commissionable. 🖤ABOUT ME: Being a boy mom of two, a wife of 13 years and a business owner, I strive to bring my network valuable and relatable content. I have a passion for helping others build their confidence, proving that beauty comes in all different forms, and being a consistent reminder that self-love is the most powerful love. I have built a community that values different perspectives on life, motherhood, beauty, skincare and so much more. My goal is to always be authentic. To share products I love while showing that makeup, skincare and fashion don't have to be complicated or intimidating. I hope you follow along to see the vast options available to you in the beauty category. Much love, Kelly Rose
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