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In this episode of the Pharm So Hard Podcast, the hosts discuss GLP-1 receptor agonists, a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. They provide an overview of the history and development of GLP-1 receptor agonists, highlighting their clinical superiority and various benefits. The hosts also explain the role of GLP-1s in the body, including their glucose-dependent insulin secretion and effects on gastric emptying. They discuss the impact of GLP-1s on hunger and mental health, emphasizing the reduction of food noise and improvement in satiety levels. Additionally, they differentiate GLP-1 receptor agonists for diabetes and weight loss and explore their indications and guideline positioning. Takeaways • GLP-1 receptor agonists are a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. • GLP-1 receptor agonists have shown clinical superiority to other anti-hyperglycemic drugs, improving glycemic control, reducing weight loss and blood pressure, and providing cardio-protective benefits. • GLP-1s increase glucose-dependent insulin secretion, block glucagon secretion, and slow gastric emptying, leading to improved blood sugar control and increased satiety. • GLP-1 receptor agonists have a positive impact on mental health, reducing food noise and helping individuals make healthier food choices. • Different GLP-1 receptor agonists have specific indications for diabetes and weight loss, and their use is guided by clinical guidelines. • GLP-1 receptor agonists are FDA-approved for improving glycemic control in patients with type 2 diabetes and for the treatment of obesity. • The choice of GLP-1 receptor agonist depends on factors such as comorbidities, weight loss goals, and patient preferences. • GLP-1 receptor agonists have different dosing regimens, and the specific dose may vary based on the indication and the product. • Common side effects of GLP-1 receptor agonists include nausea, vomiting, and diarrhea, but these side effects often improve with continued use and proper management. GLP-1 agonists can cause loss of appetite as a side effect. • GLP-1s are being used off-label for conditions such as NAFLD and depression. • GLP-1s may have positive effects on bone health and blood pressure. • The high cost of GLP-1s poses challenges for patient access. Chapters 00:00 Introduction to GLP-1 Receptor Agonists 01:12 History and Development of GLP-1 Receptor Agonists 06:14 The Role of GLP-1s in the Body 09:38 Effects of GLP-1s on Hunger and Mental Health 11:17 Differentiation of GLP-1 Receptor Agonists for Diabetes and Weight Loss 11:44 Indications and Guideline Positioning of GLP-1 Receptor Agonists

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Can therapeutic nutritional ketosis (aka a keto diet) help with tapering psychiatric medications in conditions like bipolar disorder, depression, schizophrenia, anxiety, or other psychiatric illness? Can you decrease or even stop taking some or all of your medications? There is no universal answer to this question; it depends on the individual. Psychotropic medications are typically first-line therapy for treating serious mental illness and can be life-saving. But over time, medications alone may not be completely effective in treating symptoms. And especially at high doses, they can come with problematic side effects. Metabolic nutritional therapy, specifically with nutritional ketosis, can add another treatment layer and may help promote cognitive function, mood stability and energy and overall functioning. Anecdotal evidence and growing numbers of case reports show that nutritional ketosis can help people be well enough to consider lowering the doses and number of their medications. That said, we cannot stress enough that it is essential that anyone considering reducing their medications work with their prescribing clinician, whether or not they are using nutritional ketosis as a treatment strategy. Table of Contents: 0:00 - Introduction 3:45 - Interview with Dr. Georgia Ede 32:16 - Interview with Matt Baszucki 53:59 - Conclusion Experts featured in this video: Georgia Ede, MD - www.diagnosisdiet.com Twitter @GeorgiaEdeMD Ketogenic Diets and Psychiatric Medications https://www.psychologytoday.com/us/blog/diagnosis-diet/201803/ketogenic-diets-and-psychiatric-medications Matt Baszucki, co-host of Bipolarcast on YouTube Bipolarcast Episode 1: Interview with Matt Baszucki on Ketogenic Diet and Bipolar Disorder https://www.youtube.com/watch?v=zNI8asTF5w8&t=2s Study Referenced: The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients https://pubmed.ncbi.nlm.nih.gov/35873236/ Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MedicationReduction #BipolarTreatment #MetabolicNeuroscience #KetogenicMetabolicTherapy #DepressionTreatment #NutritionalKetosis #MentalIllnessTreatment #MentalHealthIsMetabolicHealth #BipolarDiet #TaperingPsychiatricMedications #TaperMeds #KetoTaperingMeds #KetoPsychMeds #TaperMedsBipolar #TaperDepressionMeds

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Timestamps:- 0:00 - 1:11 - Intro 1:12 - 1:26 - Physics chemistry biology 1:27 - 1:58 - Psudo Intelligents 1:59 - 2:46 - What is Harmones? 2:47 - 4:15 - Type's of Harmones 4:16 - 4:31 - How? Harmones impact's your body? 4:33 - 5:33 - How? Insulin works? 5:34 - 6:17 - How? Growth Hormone Work's? 6:18 - 7:09 - How insulin Help's Growth Hormone 7:10 - 8:00 - Liver king Leaked E-mail Disclaimer:- I am not a medical professional and this channel doe's not promote any illegal activities and i and this channel are not liable for any of your damage this channel and videos is ment for educational purpose only! Title: How Keto Slowly Kills You | Part 1: Hormonal Imbalance & Accelerated Aging Description: Hey there, and welcome back to Giridhar VK! I’m Giridhar, and today, we’re kicking off Part 1 of a two-part series exploring the hidden dangers of the keto diet. So, keto’s all the rage—but what if it’s doing more harm than good? In this video, we’re going beyond the surface to reveal how keto could actually be messing with your body in surprising ways. Today’s focus: hormones and aging. Ever wonder why some people on keto feel drained or moody? Or why they seem to age faster? We’ll look at the science behind how keto diets can disrupt hormones—impacting your energy, mood, and even your skin. You might be shocked at what we uncover! We’ll break down how keto can send your body’s natural hormone cycles into a tailspin, causing imbalances that could impact your long-term health. If you’re thinking about keto or already on it, this video is for you. It’s all about knowing the real impact of these diets so you can make informed choices. Be sure to subscribe and stay tuned for Part 2, where we’ll keep exploring keto’s effects in even more depth! Each and every proofs:- How keto works in cellular level and influence human bio chemistry https://www.ruled.me/guide-keto-diet/ Harvard University research:- https://www.health.harvard.edu/nutrition/what-is-the-carnivore-diet Liver king Leaked E-mail:- https://www.reddit.com/r/JoeRogan/comments/z8htt5/leaked_emails_from_liver_king_about_his_steroid/?rdt=42835 tags:- #ketodietmyths #ketoimpact #ketogenicrisks #ketotruth #ketofad #ketodiet

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Christina Aguilera has shocked her longtime fans after appearing completely unrecognizable in a new photoshoot. The 44-year-old, who has been rumored to have used Ozempic, covered Carcy magazine with a new look following her drastic weight loss. In one image, the Beautiful singer sat cross legged in a chair while wearing a flimsy gold mini-dress. Her blonde hair was tousled and she had smoky eye makeup on. While the shoot drew a lot of praise, many initially failed to recognize that Christina was the subject. 'Why does she have a different face every time we see her?' asked one. 'How Is She Benjamin Buttoning? I've always been such a huge Christina fan and it's been so nice to see her look so happy, healthy and Thriving lately and this shoot is So Gorgeous,' gushed another. 'I thought that was Nicola Peltz for a second,' added another. A fourth speculated, 'Ozempic not only made her lose weight but changed her face too. #ChristinaAguilera #SkinnyFrame #Ozempic #UnrecognizableAppearance #Agingbackwards #

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Once you do decide that you’re ready to invest in a protein powder, it’s important that you first get well informed of the differences between the various protein powder types out there (e.g. whey protein isolate vs whey protein concentrate) , as well as the things to look for and things to avoid when comparing different brands. This helps you get the best protein powder available. By the end of this video, you’ll know exactly how to pick the right protein powder type for you, and how to separate the good from the not-so-good options out there. First, let’s cover what the best protein powder type may be for you. Now, research has made it clear that Whey protein comes out on top. This is because Whey protein is both higher in leucine, one of the most important amino acids for muscle growth, and more effectively absorbed and used by the body when compared to various other protein powders and other protein sources in general. But Whey protein can be further broken down into: Whey Concentrate, Whey Isolate, and Whey Hydrolysate. When it comes to whey protein isolate vs whey protein concentrate, the main difference here is that Whey Concentrate can range anywhere from 35-80% protein and typically contain the highest amount of lactose, carbs, and fats. Whereas Whey Isolates, although typically a bit more costly, are required to be at least 90% protein by weight, and therefore have considerably less fat and carbs. Hydrolysates on the other hand are whey concentrates or isolates that have been “pre-digested” to help with its absorption but have not been shown to be any more effective at increasing size or strength, yet is typically the most expensive option. Meaning that for the best bang for your buck, for most people a good quality Whey isolate protein is your best bet. Plant-based options can be good if you have intolerances or sensitivities to Whey. The problem with plant-based proteins though is that they tend to be deficient in certain Essential Amino Acids and are less effective at promoting protein synthesis than Whey is. But you can partially compensate for this by combining different plant-based sources (e.g. a blend of rice and pea protein). Soy protein, although subject to much controversy, is another good plant-based protein powder. Now, after you’ve chosen the protein powder (of all the protein powder types available) that best suits your needs, the next step is learning how to separate the good brands from the not-so-good brands. The first thing to avoid is the use of something called proprietary blends. You can do so by looking at the amount of protein you’re actually getting relative to the total scoop size. The next trap you want to avoid falling for is something called protein spiking. Some companies add cheap nitrogen containing compounds into their formula, such as BCAA’s or creatine. To avoid this, again, just take a closer look at the nutrition label. The last and final thing to look out for is contamination (heavy metals and plastic derivatives). To minimize your risk as a consumer, simply find out what their testing protocols are and specifically what they test for. Here are the main points to keep in mind when it comes to how to pick the right protein powder: 1. Whey isolate protein is likely the best bang for your buck. If going for a plant-based option, opt for a mixed protein powder (e.g. rice/pea protein). 2. Avoid powders with proprietary blends by looking closely at the nutrition label. There should not be a ton of listed ingredients (e.g. “blends”) nor should there be a big gap between the actual protein you get per serving compared to the total serving size. 3. To potentially avoid harmful levels of contaminants, do some research on the quality-control practices and testing protocols of the manufacturer. If you’re going to be investing in protein, it’s worth putting in the additional effort to ensure that what you’re getting is a high quality product aligned with your specific goals. And for a step-by-step program that applies this same level of science and detail to your workouts, nutrition, and supplementation so that you can truly transform your body in the most efficient way possible, then simply take the analysis quiz to discover which science-based program would be best for you and where your body is currently at below: https://builtwithscience.com/bws-free-fitness-quiz/gender?utm_source=Youtube&utm_medium=Video&utm_content=Description%20box&utm_campaign=Pick%20best%20protein%20powder%20Dec%2020%2F2020 Subscribe to my channel here: https://www.youtube.com/jeremyethier/?sub_confirmation=1 TIMESTAMPS: 0:00 - What is the best type of protein powder? 1:23 – The 3 types of Whey protein 2:59 – The best plant-based protein 4:13 – Proprietary blends (avoid these!) 6:47 – Protein spiking 9:39 – Contamination 10:43 – Summary & Application MUSIC: https://soundcloud.com/iamryanlittle