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If orforglipron is eventually approved by federal regulators, it would become the first GLP-1 oral drug for weight loss to hit the market. While Novo Nordisk currently makes an oral GLP-1 drug, it’s only approved for diabetes; it also uses a lower dose than orforglipron and produces about half the weight loss on average. Orforglipron comes with no food or drinking restrictions, while people have to take Novo’s drug 30 minutes before eating or drinking, and must limit their consumption of fatty, spicy, and sweet foods. The implications—if Lilly’s drug makes it through the testing and review process—could be transformative, not just for the company, but for patients.

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