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Discover the inspiring journey of Kelly Clarkson as she opens up about her weight loss following a pre-diabetic diagnosis, highlighting the crucial role of health in her life. Join us as we delve into the laughter-inducing and admirable transformation of Sofia Vergara for a role. Through Kelly's humor and Sofia's dedication, viewers are motivated to prioritize wellness and authenticity in their own lives.

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Chrissy Metz explained to guest host Mario Lopez how she met her boyfriend during the pandemic and how they managed to date in quarantine. The actress also shared how she felt about "This Is Us" coming to an end and whether she knows how the beloved series will end. Plus, in honor of "This Is Us," they played a game called "This Is Me, This Is Not Me" to learn more about Chrissy and Mario! #ChrissyMetz #MarioLopez #Ellen #TheEllenShow #EllenDeGeneres Subscribe to The Ellen Show: https://ellen.tv/3D6Sewq FOLLOW THE ELLEN SHOW Instagram: https://www.instagram.com/theellenshow/ Facebook: https://www.facebook.com/ellentv/ Twitter: https://twitter.com/TheEllenShow TikTok: https://www.tiktok.com/@ellendegeneres Website: https://www.ellentube.com/ The place for laughs, joy, stars, surprises, and everything Ellen. How Chrissy Metz Met Her Boyfriend During the Pandemic https://youtu.be/Q39eANncC-I

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Success Stories: Cinnamon's Journey with GLP-1 Medications on The Downsized Dish This episode of The Downsized Dish features Laraine Durham, who interviews Cinnamon about her transformative GLP-1 weight loss journey. Cinnamon shares her background, weight loss statistics, and experiences with various weight loss methods, including GLP-1 medications like Ozempic and Zepbound. Despite initial challenges, Cinnamon successfully lost 110 pounds and continues to work towards her goal weight. She discusses her workout routines, dietary habits, and the supportive environment of the Downsized community. The episode also highlights the importance of self-education, having a support network, and preparing for potential side effects. Additionally, there's a special mention of an upcoming cruise with The Downsized community, offering more opportunities for support and camaraderie. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at... DOWNSIZED WEBSITE: https://thedownsized.org/ DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store JOIN CLUB DOWNSIZED: @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction to The Downsized Dish 00:48 Meet Our Guest: Cinnamon 01:32 Cinnamon's Weight Loss Journey 03:44 Challenges and Side Effects 09:16 Fitness and Exercise Routine 13:33 Diet and Eating Habits 14:41 Discussing Tracking Apps and Calorie Goals 15:07 Breaking Through Weight Loss Plateaus 16:15 Wardrobe Changes and Weight Loss 17:12 Insurance and Medication Coverage 18:57 Preparing for the Downsize Cruise 19:57 Community Support and Family Impact 22:27 Diet Changes and Protein Focus 26:13 Final Thoughts and Advice

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Professor Barry Borlaug presents the SUMMIT trial on the use of the GIP / GLP-1 receptor dual agonist in patients with obesity-associated Heart-Failure with Preserved Ejection Fraction, which has been published in New Engl J Med 2024 and elected the most important study in cardiology and lipidology 2024 by MARKUS at HOMe. Dr. Borlaug is Professor of Medicine and Director, Circulatory Failure Research, Division of Cardiovascular Diseases, and Chair for Research, Division of Circulatory Failure, Department of Cardiovascular Medicine at the Mayo Clinic, Rochester, Minnesota. He is a global leader in studies on mechanisms, diagnosis and treatment of heart failure, particularly heart failure with preserved ejection fraction (HFPEF). The interview was recorded on January 16th, 2025. Moderators: Prof. Dr. Dr. Stephan Schirmer (Kaiserslautern, Germany), Prof. Dr. Florian Custodis (Saarbrücken, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany). Articles discussed: GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders. Leggio L, Hendershot CS, Farokhnia M, Fink-Jensen A, Klausen MK, Schacht JP, Simmons WK. Nat Med 2023 doi: 10.1038/s41591-023-02634-8 Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy. Kramer CM, Borlaug BA, Zile M MR, Ruff D, DiMaria JM, Menon V, Ou Y, Zarante AM, Hurt KC, Murakami M, Packer M; SUMMIT Trial Study Group. J Am Coll Cardiol 2024 doi: 10.1016/j.jacc.2024.11.001 Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, Ge J, Weerakkody GJ, Ou Y, Bunck MC, Hurt KC, Murakami M, Borlaug BA; SUMMIT Trial Study Group. N Engl J Med 2024 doi: 10.1056/NEJMoa2410027 Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial. Borlaug BA, Zile MR, Kramer CM, Baum SJ, Hurt K, Litwin SE, Murakami M, Ou Y, Upadhyay N, Packer M. Nat Med 2024 doi: 10.1038/s41591-024-03374-z Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction. Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA. Circulation 2017 doi: 10.1161/CIRCULATIONAHA.116.026807 An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score. Reddy YNV, Carter RE, Sundaram V, Kaye DM, Handoko ML, Tedford RJ, Andersen MJ, Sharma K, Obokata M, Verbrugge FH, Borlaug BA. Nat Med 2024 doi: 10.1038/s41591-024-03140-1 A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction. Reddy YNV, Carter RE, Obokata M, Redfield MM, Borlaug BA. Circulation 2018 doi: 10.1161/CIRCULATIONAHA.118.034646 How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G. Eur J Heart Fail 2020 doi: 10.1002/ejhf.1741 Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial. Tada A, Burkhoff D, Naser JA, Harada T, Pourmussa B, Reddy YNV, Jensen MD, Carter RE, Demmer RT, Testani JM, Chirinos JA, Borlaug BA. Circulation 2024 doi: 10.1161/CIRCULATIONAHA.124.068788 Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The CAMEO-DAPA Trial. Borlaug BA, Reddy YNV, Braun A, Sorimachi H, Omar M, Popovic D, Alogna A, Jensen MD, Carter R Circulation 2023 doi: 10.1161/CIRCULATIONAHA.123.065134

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