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Click Here to Subscribe: http://Bit.ly/ThomasVid Website: http://ThomasDeLauer.com Get the Apparel I Wear at http://Hylete.com Ketogenic Diet vs. Kidneys | Keto’s Effect on the Kidneys | Kidneys Stones Explained- Thomas DeLauer… Keto & Gene Expression: A study published in the journal Kidney International looked at nephropathy (term used when the kidneys start to incur damage, which can ultimately lead to kidney failure) in diabetic mice (3) The researchers found the genes responsible for nephropathy (nephrin, ZO-1 and podocin) were reversed - this helped restore the mice’s kidneys back to healthy functioning. Specifically, the study found that keto increased the expression of SIRT1, which led to a reduction in the genes responsible for nephropathy. In indications of energy surplus, such as glycogen and insulin, inhibit activation of AMPK - ketosis decreases these factors that inhibit AMPK. Through a very long process ketosis is able to activate SIRT1 indirectly through activation of AMPK. https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2781128 SIRT1: SIRT1 is a protein or vehicle that requires NAD+ to function - SIRT1 takes acetyl groups off of proteins. SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation, in fat synthesis and storage, and in blood sugar management. When proteins are undergoing stress, acetyl groups are added to proteins as a response to changes induced by inflammation and oxidation. Sirtuins (like SIRT1) remove these acetyl groups to keep the protein in service longer than usual, while simultaneously stabilizing the charge state of the carbon backbone in protein to resist any further changes in their shape. This allows your cellular proteins to live longer and you can save energy on other processes. Keto & Glomerular Lesions: Glomerular filtration rate (GFR) is a test to measure how well the kidneys filter blood and remove waste. Glomeruli, the small units within the kidney where blood is filtered - they act as tiny filters within the kidneys and each kidney contains millions of glomeruli. If the glomeruli become damaged, the kidney can no longer remove waste and excess fluids efficiently - blood and protein cannot be filtered and are excreted in the urine. Too much glucose may cause glomerular lesions in patients with poor glucose control, leading to impairment of the kidneys. Glomerulonephritis, a group of diseases that cause inflammation and damage to the kidney's filtering units - glomerulonephritis refers to a range of inflammatory kidney conditions of the tiny blood vessels in the kidneys. High glucose levels are thought to make the blood flow into the kidney at a higher speed, putting a strain on the filtering process and raising blood pressure. The capillaries in the glomerulus collapse and can leave the glomeruli with scarring. Meta Analysis - British Journal of Nutrition: The review measured the impact of low carb diet on renal function taking into account 1000 people from nine randomised controlled trials found that: “a low carbohydrate diet and the corresponding high-protein diet was not harmful for renal function in overweight and obese individuals without renal dysfunction.” Furthermore, it concluded that a low carb diet may even improve renal function thanks to its weight loss effects. References: 1) Impact of low-carbohydrate diet on renal function: a meta-analysis of over 1000 individuals from nine randomised controlled trials. (2016, August 28). Retrieved from https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/impact-of-lowcarbohydrate-diet-on-renal-function-a-metaanalysis-of-over-1000-individuals-from-nine-randomised-controlled-trials/0EAA25E700C06D2C5125F0AB195FB33F 2) University of Wisconsin Hospitals and Clinics Authority. (2010, June 24). How Do Kidney Stones Form? Retrieved from https://www.uwhealth.org/urology/how-do-kidney-stones-form/11210 3) Nesbitt, H. (n.d.). Kidney Week. Retrieved from https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2781128 4) Hong Q , et al. (n.d.). Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29477240 5) Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health. (2018, February 11). Retrieved from https://www.hindawi.com/journals/jnme/2018/5157645/

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Can a sweetener actually help with weight loss and blood sugar control? Possibly, with allulose. Allulose is a rare sugar that’s creating a buzz. Unlike artificial sweeteners, which have been linked to weight gain and insulin resistance, allulose boosts GLP-1, may improve the gut microbiome and has been shown in multiple studies to help with fat loss and blood sugar regulation. In this video, we dive into: ✅ How allulose impacts GLP-1 and metabolism ✅ The scientific studies behind allulose and weight loss ✅ How allulose compares to artificial sweeteners like stevia and aspartame ✅ Potential side effects and the best ways to use it #Allulose #GLP1 #WeightLoss #BloodSugarControl #MetabolismBoost #InsulinResistance #SweetenerAlternatives #Ozempic #GLP1Agonist #KetoFriendly #DiabetesSupport #GutHealth #LowCarb #MetabolicHealth

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Christina Aguilera recently sparked concern among fans after a video of her at an event went viral, showcasing a noticeable weight loss transformation. Social media users are buzzing with speculation about her health, with some suggesting she may be using Ozempic, while others wonder if she has undergone cosmetic surgery. In this video, we dive into the rumors surrounding Christina’s appearance, her response (or lack thereof), and what fans are saying about her dramatic transformation. Is there more to the story than meets the eye? Watch to find out!

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Here I discuss the recent advances and old history of GLP-1RA drugs like ozempic in the context of biotechnology. Timestamps: 0:00 GLP-1 Introduction 1:00 Papers discussed 1:40 GLP-1 4:26 GLP-1 Receptor 6:50 GLP-1 Receptor Agonists 8:00 DPP4 peptidase 10:50 GLP1 Biotech 12:45 Protein Sequencing Methodologies 13:30 Edman Degradation 15:15 LC-MS/MS 17:00 Finding Gene Sequences from Proteins 19:00 Orthologs and Analogs 22:00 Measuring cAMP 25:00 Semaglutide Ozempic 30:00 Mass Production of Semaglutide 34:20 Yeast Plasmid 36:20 Final Thoughts

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