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We know they are expensive, but isn’t the cost recouped by the healthcare savings? Dr F. Perry Wilson explains. https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt --TRANSCRIPT-- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. Much of my time in these videos is spent talking about whether a drug or supplement or diet or intervention works or not. That’s the central focus of medical science: Can we do something for a patient and make a difference in their health? But there’s a related question that we rarely discuss that is almost equally as important: Is this drug or supplement or diet or intervention worth it? And I don’t mean “worth it” in some meta-physical sense. I mean "worth it" in terms of dollars and cents. Is the cost we pay for something worth the benefit we derive from it? I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no. How do we decide if a drug is cost-effective? What does that even mean? I’ll give you some extreme examples to illustrate the point a bit. First, for it even to be possible that a drug is cost-effective, it must be effective. It must improve health in some clear, measurable way. Pink jelly beans, while quite inexpensive, do not improve health at all and are therefore not cost-effective. Policymakers should not advocate that insurers cover pink jelly beans. On the flip side are drugs and interventions that actually make money for the system — things that are so good for you, they save money in the long term. The childhood vaccination program is probably the best example of this. The CDC estimates that for every $1 spent on the program, the payer saves about $3 in future costs and society saves about $10 in future costs. This is why insurers have no problem covering childhood vaccines; they would literally be leaving money on the table if they didn’t. So those are the extremes. Don’t pay for pink jelly beans, do pay for vaccines. But we don’t think it is appropriate to cover only stuff that saves money. We are willing to trade money for longer life or quality of life. And this is where the rubber meets the road when it comes to cost-effectiveness analysis: How much is your life worth? To an economist, the answer is basically $100,000 per year of perfect health. The ways they arrive at this number are pretty fascinating, but a lot of it is done by looking at what we as a society are willing to pay for. A cost of $100,000 per “quality-adjusted life year” (QALY) is our standard candle here. More than that is not particularly cost-effective. Less than that is. The “quality” in the QALY is important too. Economists know that a year of perfect health is worth more, in dollar terms, than a year of moderate or poor health. So, if we take an intervention and do some clever modeling based on the price of the intervention and its effectiveness at improving health, we can tell you how much it costs per QALY. Here are a few examples. We have an intervention to pay people to quit smoking. This costs about $2500 per QALY. Seems pretty good. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt

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Losing weight isn’t easy, and it’s not the same journey for every person. Patrick (Rick) Northcraft, of the Valley Health Metabolic & Bariatric Program, highlights a five-step plan for reaching your goals.

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Over the years, the ketogenic diet has gained popularity for its ability to help individuals lose weight and improve their overall health. One product that has recently gained attention in the weight loss community is Keto Melt, a supplement that claims to help users achieve ketosis faster and burn fat more efficiently. With its appearance on the hit television show Shark Tank, many people are curious about whether Keto Melt is the real deal or just another weight loss gimmick.

The Science Behind Keto Melt

Keto Melt is designed to help users reach a state of ketosis, where the body burns fat for fuel instead of carbohydrates. The supplement contains exogenous ketones, which are ketones that are produced outside of the body and can help jumpstart the ketosis process. By taking Keto Melt, users may be able to achieve ketosis faster and experience increased fat burning, leading to weight loss.

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Additionally, Keto Melt may also help suppress appetite and reduce cravings, making it easier for users to stick to the ketogenic diet and avoid overeating. This can further contribute to weight loss and improved body composition.

How to Use Keto Melt

To use Keto Melt, simply take the recommended dosage as indicated on the label. It is important to follow the instructions carefully to ensure maximum effectiveness and safety. Users should also continue to follow a ketogenic diet while taking Keto Melt, as this will help optimize the results of the supplement.

It is recommended to stay hydrated while taking Keto Melt and to engage in regular physical activity to enhance the fat-burning effects of the supplement. Consistency is key when using Keto Melt, so it is important to take the supplement daily and make healthy lifestyle choices to support your weight loss goals.

Potential Benefits of Keto Melt

One of the main benefits of Keto Melt is its ability to help users achieve ketosis faster and more efficiently. This can lead to increased fat burning, weight loss, and improved energy levels. Additionally, Keto Melt may help control appetite and cravings, making it easier for users to maintain a calorie deficit and lose weight.

Some users may also experience improved mental clarity and focus while taking Keto Melt, as ketones are known to provide an alternative source of energy for the brain. This can be especially beneficial for individuals who struggle with brain fog or cognitive decline.

Potential Side Effects of Keto Melt

While Keto Melt is generally considered safe for most people, some users may experience side effects when taking the supplement. Common side effects of exogenous ketones include digestive issues such as stomach discomfort, diarrhea, and constipation. These side effects are typically mild and temporary, but if they persist or worsen, it is important to discontinue use of Keto Melt.

Individuals with certain medical conditions, such as diabetes or kidney disease, should consult with a healthcare provider before taking Keto Melt. Pregnant or nursing women should also avoid taking the supplement, as its effects on fetal development and breastfeeding infants are not yet fully understood.

Customer Reviews of Keto Melt

Many users who have tried Keto Melt report positive results, including weight loss, increased energy, and improved overall health. Some customers have praised the supplement for helping them break through weight loss plateaus and achieve their fitness goals faster than with diet and exercise alone.

However, it is important to note that individual results may vary, and not everyone will experience the same benefits from taking Keto Melt. It is always recommended to consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or concerns.

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If your metabolism has slowed… If you feel like your workouts aren’t “working” anymore… It’s probably not age. It’s not your willpower. It’s your hormones—and stress is the trigger. When cortisol (your stress hormone) is high, your body holds on to fat. Matcha does something coffee can’t: ✨ It helps your body calm down while staying energized ✨ It supports metabolic function through EGCG + L-theanine ✨ It gives you clean energy with no crash and no cravings Zen Tea Leaf matcha is the secret weapon for the overworked, overstressed, and under-recovered. 👉 Start with just one cup a day! Your metabolism isn’t broken. It just needs better support. #stressandfatloss #matchametabolism #zenfatburn #energysmart

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