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All GLP-1 receptor agonists share a common mechanism, activation of the GLP-1 receptor. GLP-1 receptors are expressed by β cells, cells in the peripheral and central nervous systems, the heart and vasculature, kidney, lung, and GI mucosa. Binding of agonists to the GLP-1 receptor activates the cyclic AMP-PKA pathway and several GEFs (guanine nucleotide exchange factors). GLP-1 receptor activation also initiates signaling via PKC and PI3K and alters the activity of several ion channels. In β cells, the end result of these actions is increased insulin biosynthesis and exocytosis in a glucose-dependent manner

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Get My Diet & Workout Program ► http://bit.ly/SFINNERCIRCLE Subscribe for More Videos ► http://bit.ly/jordansyattyoutube ---- HOW TO USE CARB CYCLING FOR FAT LOSS ---- 💥CARB CYCLING💥 Before you read anything below it's important to clarify one major point: the fitness industry LOVES to overcomplicate stuff. The bigger the word and fancier the name the better it sounds and the more it can sell. Carb Cycling, for example, *sounds* fancy. And a lot of coaches come up with elaborate schemes and explanations to make it sound way more impressive than it really is. (Similar to how many overcomplicate Intermittent Fasting as well). Here's the deal. At it's core, carb cycling is simply this: some days you eat higher carb/lower fat. Other days you eat lower carb/higher fat. That's it. Period. End of story. Yes, there are ways to manipulate it based on individual needs and preference. But the big rocks are simply a mix of high carb/low fat and low carb/high fat days throughout the week. Most important of all, carb cycling is NOT a replacement for calories. In other words, calories still count regardless of whether or not you carb cycle. So if you're struggling to lose weight and are thinking of carb cycling, that's amazing and I support you and will help you. But FIRST you need to get your calorie intake in check. Having said all of that, my preferred carb cycling schedule is EITHER 3 high carb + 4 low fat days OR 4 high carb + 3 low fat days. Both options are totally fine and work just as well. The key is to find what YOU enjoy most so you can stick with it long-term. Also, I usually prefer to have my high carb days on training days because they give me more energy for working out. BUT you do NOT need to do that so long as total calorie intake is in check at the end of the week. Want to try it? Awesome! First get your cals in check, then your protein. Once those are in order you can establish the carb cycling schedule that works best for you and plug & play from there. Remember, there's no "right" or "wrong" way to do this. Find what you enjoy most, makes you feel the best, and stick with that. And if anyone tells you otherwise...we'll...you can tell them to 🖕off. I hope this helps and, as always, any questions leave em below ---- Do NOT subscribe unless my videos are actually helpful. The point of this channel is to help you, not promote me. So if my videos don't give you value...don't subscribe. If they do, though, please hit the sub button (it helps a lot!). - You and I are going to drink a lot of coffee together. Like, borderline dangerous amounts of coffee. So, first things first. Pour yourself a mug and I’ll introduce myself real quick. My name’s Jordan — but everyone calls me “J” — and I’m a 27th degree black belt in chugging coffee. I’m also strength & nutrition coach, I hold several powerlifting world records, and I’ve been fortunate enough to have my writing featured in a variety of outlets like CNN, the Huffington Post, and Schwarzenegger.com. But listen. This channel isn’t for fame, publicity, cash, props, fist bumps, likes, pings, pows or whatever else there is. It’s a place where you and I can chat. I’ll never sugar coat, lie, or beat around the bush. I’ll tell you everything exactly as I see it. Some stuff you might like. Others you might not. And that’s totally cool. Either way, my goal here is to create a discussion. A place where you and I can get together, exchange ideas, and motivate each other to be better every day. Like I said, we’re gonna drink a lot of coffee together — borderline dangerous amounts — but I’m excited. Because there aren’t too many online communities in which the sole purpose is to inspire and motivate one another. And that’s exactly what you and I are going to do here. To your success, -J - #carbcycling #carbcyclingdiet #carbcyclingforfatloss

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​Hims & Hers Health Inc. (NYSE: HIMS) experienced a significant stock surge following its partnership with Novo Nordisk to offer the FDA-approved weight-loss drug Wegovy (semaglutide) through its telehealth platform. This collaboration allows Hims & Hers to provide all doses of Wegovy bundled with a monthly membership starting at $599, enhancing access for patients without insurance. ​ Previously, Hims & Hers had been selling compounded versions of semaglutide during a period of drug shortages. However, the FDA recently declared the shortage over, leading to restrictions on compounded alternatives. The new partnership with Novo Nordisk positions Hims & Hers to continue offering weight-loss treatments legally and sustainably. ​ As a result of this strategic move, HIMS stock surged over 27%, reflecting investor confidence in the company's expanded offerings and its potential to capture a larger share of the growing weight-loss drug market.

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