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REFERENCE for Curious Interested Listeners & Physicians 48,25mar In Part 2 of our deep dive into Mounjaro vs. Ozempic, we’re busting myths and uncovering what doctors aren’t always saying. Here’s what we’ll cover: • Myth 1: “All GLP-1 drugs are the same.” • Reality: Ozempic targets a single pathway, while Mounjaro works on two—leading to potential greater weight loss in some, but it’s not a one-size-fits-all. • Myth 2: “These drugs only make you eat less.” • Reality: They also influence the brain’s reward system, reducing cravings and the emotional drivers of eating, not just physical hunger. We’ll break down how these medications work, the real-world impact, and why individual responses vary. Stay tuned Part 3 for more insights into what doctors might not be telling you about these weight loss treatments! 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp

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Are you looking to shed some extra pounds and struggling with traditional weight loss methods? If so, you may have heard of Semaglutide weight loss treatment. Semaglutide is a medication that has shown promising results in helping individuals achieve their weight loss goals. In this article, we will explore what Semaglutide weight loss is and how it works to help individuals lose weight.

How Semaglutide Works for Weight Loss

Semaglutide is a medication that belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These drugs work by mimicking the effects of a hormone called GLP-1, which is naturally produced by the body in response to food intake. GLP-1 helps regulate blood sugar levels and plays a role in appetite regulation, making you feel full and satisfied after eating.

When Semaglutide is injected, it activates GLP-1 receptors in the brain, leading to a decrease in appetite and food intake. This can result in reduced calorie consumption, which is key to weight loss. Additionally, Semaglutide may also slow down the emptying of the stomach and increase feelings of fullness, further aiding in weight loss efforts.

Studies have shown that Semaglutide can lead to significant weight loss in individuals who are overweight or obese. In fact, clinical trials have demonstrated that Semaglutide can help individuals lose up to 15% of their body weight, making it a promising option for those struggling to lose weight through diet and exercise alone.

Potential Side Effects of Semaglutide

Like any medication, Semaglutide may cause side effects in some individuals. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.

It is important to note that Semaglutide is not suitable for everyone, and individuals with a history of pancreatitis or thyroid cancer should not take Semaglutide. Additionally, Semaglutide may interact with other medications, so it is important to consult with a healthcare provider before starting treatment with Semaglutide.

If you experience any severe or persistent side effects while taking Semaglutide, it is important to seek medical attention immediately. Your healthcare provider can help determine whether Semaglutide is the right weight loss treatment for you and may adjust your dosage or recommend alternative options if needed.

Benefits of Semaglutide for Weight Loss

In addition to promoting weight loss, Semaglutide has been shown to have other health benefits. Studies have demonstrated that Semaglutide can improve blood sugar control in individuals with type 2 diabetes and reduce the risk of cardiovascular events such as heart attacks and strokes.

Furthermore, Semaglutide may also help improve other metabolic markers, such as cholesterol levels and blood pressure, leading to overall improvements in health. By helping individuals achieve weight loss and improve their overall metabolic health, Semaglutide has the potential to reduce the risk of chronic diseases associated with obesity, such as diabetes and heart disease.

Overall, Semaglutide is a promising treatment for weight loss that offers a safe and effective option for individuals struggling to lose weight through traditional methods. By targeting appetite and food intake, Semaglutide can help individuals achieve significant weight loss and improve their overall health and well-being.

FAQs about Semaglutide Weight Loss

Is Semaglutide safe for weight loss?

Semaglutide has been shown to be safe and effective for weight loss in clinical trials. However, like any medication, Semaglutide may cause side effects in some individuals. It is important to consult with a healthcare provider before starting treatment with Semaglutide to determine if it is the right option for you.





How much weight can I expect to lose with Semaglutide?

Studies have shown that Semaglutide can help individuals lose up to 15% of their body weight. However, individual results may vary, and weight loss results will depend on factors such as diet, exercise, and overall health status.

Are there any long-term effects of taking Semaglutide for weight loss?

Long-term studies on the effects of Semaglutide for weight loss are still ongoing. However, initial studies have shown that Semaglutide can lead to sustained weight loss and improvements in metabolic health markers. It is important to continue monitoring your health and working with your healthcare provider while taking Semaglutide for weight loss.

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Why You Can Lose Weight The Real Reason Explained By Dr Berg