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Kelly Clarkson stuns in skinny jeans and a Fleetwood Mac T-shirt on The Kelly Clarkson Show, showcasing her incredible weight loss journey and newfound confidence. In this episode, Kelly opens up about her past struggles with jeans and how she's embracing them now. She also shares her excitement for a much-needed break ahead of Memorial Day, where she'll spend time with her kids, River and Remi, in their new NYC home. Rumors about Kelly's future on the show are swirling, but NBC continues to support her. At the 2024 Daytime Emmy Awards, she thanked NBC for helping her relocate and start fresh after her divorce. Watch to see Kelly's fashion evolution, hear her candid thoughts on life changes, and get the latest updates on her talk show journey! #KellyClarkson #TheKellyClarksonShow #WeightLossJourney #FashionTransformation #DaytimeEmmyAwards #NBC #CelebrityStyle #FleetwoodMac #SkinnyJeans #TalkShow

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CHRISTINA AGUILERA✨💋🌹👈SLAMS CRITICISMS ABOUT #christina #aguilera #slams #criticisms https://youtu.be/U7jWG8wdO8Y https://youtu.be/xxqaxZIGs5w Christina Aguilera says that nowadays, comments on the internet about her body are something she simply brushes off. In a cover story for Glamour, the “Genie in a Bottle” singer, 43, got candid about facing intense scrutiny over her appearance from the media since the 2000s, and how she’s grown not to care about what people think of her. “I have a maturity now where I just don’t give a fuck about your opinion. I’m not going to take it on,” Aguilera said in the story, published Thursday. “It must be your responsibility to take up your space. Other people’s opinions of me are not my business.” In May, Aguilera’s weight loss sparked rumors on social media that she was taking Ozempic, a diabetes treatment that controls blood sugar levels. Some people use Ozempic as an off-label weight-loss drug. Actor Rebel Wilson and TV personality Sharon Osbourne, among others, have acknowledged using Ozempic to lose weight despite a public stigma attached to it. Some social media users speculated about Aguilera’s seemingly thinner appearance on a viral TikTok video posted on May 19. One commenter wrote: “Dang, she looks amazing! Wish I could be on Ozempic like everyone else, too, but afraid of the side effects.” Aguilera told Glamour that her self-esteem used to depend on the opinions of others, and that her confidence took a hit after her peers criticized her appearance as “unacceptable” once she started getting curves later in life. “When you’re a teenager, you have a very different body than when you’re in your 20s,” she explained. “I started to fill out, and then that was unacceptable because it was like, ‘Oh, she’s getting thicker.’ Then I had industry people: ‘They liked your body and how you were as a skinny teenager.’” She said she hopes she’s given her kids the mental fortitude to ignore negative comments, because she doesn’t want them to suffer through the same experiences she did. Aguilera shares a son, Max, with her ex-husband Jordan Bratman, and a daughter, Summer, with her fiancé Matt Rutler. “Your kids trigger things in you that you don’t want them to go through,” she said. “And it’s almost like you’re reliving this whole thing again.” “I’ve seen so much so young,” Aguilera added. “You just want the best for your kids.” Copyright Disclaimer: Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS.

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, affecting around 5-10% of this population. It is characterized by hormonal imbalances, irregular menstrual periods, and the development of small cysts on the ovaries. One of the most challenging symptoms of PCOS is weight gain and difficulty in losing weight. Women with PCOS often struggle with obesity and related complications such as insulin resistance, type 2 diabetes, and cardiovascular disease. Traditional weight loss methods like diet and exercise may not always be effective in managing weight in PCOS patients. However, recent studies have shown promising results with the use of semaglutide, a medication typically used for type 2 diabetes, in helping PCOS patients achieve weight loss.

Semaglutide and PCOS Weight Loss

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of the naturally occurring hormone GLP-1. It helps regulate blood sugar levels, suppresses appetite, and promotes satiety, leading to reduced calorie intake and weight loss. In recent years, semaglutide has gained attention for its potential in managing weight in individuals with obesity and related conditions, including PCOS.

A randomized controlled trial published in the Journal of Clinical Endocrinology & Metabolism in 2020 investigated the effects of semaglutide on weight loss in women with PCOS. The study found that participants who received semaglutide injections lost significantly more weight compared to those who received a placebo. The results highlighted the potential of semaglutide as a promising treatment option for weight management in PCOS patients.

Mechanism of Action

Semaglutide works by increasing insulin secretion, decreasing glucagon secretion, slowing gastric emptying, and reducing food intake through its effect on the central nervous system. The medication binds to GLP-1 receptors in the pancreas, brain, and other tissues, regulating glucose metabolism and energy balance. By modulating these pathways, semaglutide helps individuals with PCOS achieve weight loss and improve metabolic parameters.

Additionally, semaglutide has been shown to improve insulin sensitivity and reduce inflammation, both of which are important factors in the management of PCOS. Insulin resistance is a common feature of PCOS, leading to elevated insulin levels, increased androgen production, and ovulatory dysfunction. By targeting insulin resistance and inflammatory pathways, semaglutide can address underlying metabolic abnormalities and promote weight loss in PCOS patients.

Clinical Considerations

Before starting treatment with semaglutide, PCOS patients should undergo a thorough medical evaluation to assess their overall health status and individual treatment goals. Semaglutide is typically administered as a once-weekly subcutaneous injection, gradually increasing the dosage to minimize side effects and maximize weight loss benefits. Patients may experience gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which usually improve over time as the body adjusts to the medication.

It is essential for PCOS patients to work closely with healthcare providers, including endocrinologists, gynecologists, and nutritionists, to develop a comprehensive treatment plan that includes lifestyle modifications, dietary changes, and regular monitoring of metabolic parameters. Semaglutide should be used as part of a holistic approach to weight management in PCOS, focusing on long-term sustainability and overall health improvement.

Future Directions

Research on semaglutide and its role in weight management in PCOS patients is ongoing, with several clinical trials currently underway to further explore its efficacy and safety. As our understanding of PCOS and its metabolic consequences continues to evolve, semaglutide and other GLP-1 receptor agonists may emerge as key therapeutic options for addressing weight gain and related complications in women with PCOS. By integrating pharmacological interventions with lifestyle modifications and personalized care, healthcare providers can better support PCOS patients in achieving sustainable weight loss and improving their overall quality of life.

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