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Welcome back to the CardioNerds Cardiovascular Prevention Series, where we are continuing our discussion of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs). This class of medications is becoming a household name, not only for their implications for weight loss but also for their effect on cardiovascular disease. CardioNerds Dr. Ty Sweeney (CardioNerds Academy Faculty Member and incoming Cardiology Fellow at Boston Medical Center), Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at Johns Hopkins Hospital), and special guest Dr. Franck Azobou (Cardiology Fellow at UT Southwestern) sat down with Dr. Darren McGuire (Cardiologist at UT Southwestern and Senior Editor of Diabetes and Vascular Disease Research) to discuss important trial data on GLP-1 RAs in patients with heart disease, as well as recent professional society guidelines on their use. Show notes were drafted by Dr. Ty Sweeney. Audio editing was performed by CardioNerds Intern student Dr. Diane Masket. If you haven’t already, be sure to check out CardioNerds episode #350 where we discuss the basics and mechanism of action of GLP-1 RAs with Dr. Dennis Bruemmer. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Diving into the Data Patients with diabetes and clinical atherosclerotic cardiovascular disease (ASCVD) or who are at high risk of ASCVD benefit from treatment with a GLP-1 RA. For persons with sufficient ASCVD risk and type 2 diabetes, GLP-1 RAs and SGLT2 inhibitors can, and often should, be used in combination. "Just like we don’t consider ‘and/or’ for the four pillars of guideline-directed medical therapy for heart failure with reduced ejection fraction, we shouldn’t parcel out these two therapeutic options...it should be both.” Setting expectations with your patients regarding injection practices, side effects, and expected benefits can go a long way toward improving the patient experience with GLP-1 RAs. Utilize a multidisciplinary approach when caring for patients on GLP-1 RAs. Build a team with your patient’s primary care provider, endocrinologist, clinical pharmacist, and nurse. “This is really a cardiologist issue. These are no longer endocrinology or primary care drugs. We need to be prescribing them ourselves just like we did back in the nineties when we took over the statin prescriptions from the endocrinology domain...we need to lead the way.” Show notes - GLP-1 Agonists: Diving into the Data For which patients are GLP-1 RAs recommended to reduce the risk of major cardiac events? For patients with type 2 diabetes and ASCVD, starting a GLP-1 RA carries a Class 1, Level of Evidence A recommendation in the most recent ESC and ACC guidelines. For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk. The STEP-HFpEF trial showed that among patients with obesity and HFpEF, once-weekly semaglutide may be beneficial in terms of weight loss and quality of life. The results of the FIGHT and LIVE trials question the utility and safety of liraglutide in treating patients with advanced HFrEF. Of the over 17,000 patients enrolled in the SELECT trial, about 25% had heart failure, of which about one-third had HFrEF. Stay tuned for sub-analyses from that trial for more info! Can we still prescribe GLP-1 Ras in patients with well-controlled T2DM?

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You’ve likely heard about the latest craze in weight loss — GLP-1 injections. Commonly referred to by their brand names Ozempic and Wegovy, these medications have been touted by celebs and have made headlines as the latest ‘lose weight quick’ solution we’ve all been waiting for. But like most trends, it can be hard to distinguish between misinformation and facts and to decipher how and if this applies to you and your own health goals. Check out our webinar on Ozempic Injections, Weight Loss, and Nutrition, where, Foodsmart Dietitian Madison Reeder will educate you on exactly what these medications are, debunk myths and clarify the science, and talk about the vital role of nutrition for long-term weight loss success. #weightloss #food #diet #ozempic #nutrition #foodsmart

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Apple cider vinegar (ACV) has been hailed for its numerous health benefits, including weight loss and improved digestion. It has gained popularity in recent years as a natural remedy for various health issues. Simpli ACV Keto Gummies combine the power of ACV with the benefits of a ketogenic diet in a convenient, delicious gummy form. But how effective are they really?

Benefits of Simpli ACV Keto Gummies

Simpli ACV Keto Gummies claim to offer several benefits, including weight loss, improved metabolism, increased energy levels, and better digestion. ACV is known to help regulate blood sugar levels, reduce appetite, and aid in fat burning, all of which can contribute to weight loss when combined with a healthy diet and regular exercise.

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The keto diet, on the other hand, is a high-fat, low-carb diet that forces the body to burn fat for fuel instead of carbohydrates. By combining the benefits of ACV with the principles of the keto diet, Simpli ACV Keto Gummies aim to enhance the body’s fat-burning capabilities and promote overall health and well-being.

These gummies are also convenient and easy to incorporate into your daily routine. Unlike traditional ACV supplements or the hassle of mixing liquid ACV into a drink, Simpli ACV Keto Gummies are portable and can be taken on-the-go, making it easier to stick to your health and weight loss goals.

User Reviews and Testimonials

Many users have reported positive experiences with Simpli ACV Keto Gummies. Some have noticed a decrease in cravings and appetite, leading to weight loss and improved energy levels. Others have praised the taste and convenience of the gummies, making it easier for them to stay consistent with their health regimen.

One user mentioned, “I have been struggling to lose weight for years, but since I started taking Simpli ACV Keto Gummies, I have seen a noticeable difference in my energy levels and overall well-being. The gummies are delicious and easy to take, making it simple to stay on track with my weight loss goals.”

Overall, user reviews indicate that Simpli ACV Keto Gummies are effective for weight loss and overall health when combined with a balanced diet and regular exercise. However, individual results may vary, and it’s essential to consult with a healthcare professional before starting any new supplement regimen.

Potential Side Effects and Risks

While ACV and the keto diet are generally safe for most people, some individuals may experience side effects when taking ACV supplements or following a ketogenic diet. These side effects may include digestive issues, such as stomach upset or acid reflux, as well as potential nutrient deficiencies due to the restrictive nature of the keto diet.

It’s essential to monitor your body’s response to Simpli ACV Keto Gummies and consult with a healthcare provider if you experience any adverse reactions. Additionally, pregnant or nursing women, as well as individuals with underlying health conditions, should exercise caution when considering new supplements or dietary changes.

Overall, while Simpli ACV Keto Gummies offer several potential benefits for weight loss and overall health, it’s crucial to approach any new supplement with caution and consult with a healthcare provider to ensure that it is safe and appropriate for your individual needs.

Final Thoughts

Simpli ACV Keto Gummies combine the power of apple cider vinegar with the principles of the ketogenic diet to offer a convenient and effective way to support weight loss and overall health. Many users have reported positive experiences with the gummies, praising their taste, convenience, and effectiveness.

However, it’s essential to approach any new supplement with caution and consult with a healthcare provider before starting a new regimen. While Simpli ACV Keto Gummies may be beneficial for some individuals, they may not be suitable for everyone, and individual results may vary.

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Have you been struggling to reach your weight loss goals even after following a strict keto diet? Are you looking for a way to boost your energy and increase your ketone levels to help you burn fat more efficiently? Look no further than GoKeto BHB Gummies available on Amazon! These delicious gummies are packed with exogenous ketones to give you the BHB boost you need to stay in ketosis and achieve your weight loss goals.

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GoKeto BHB Gummies are specially formulated to help you reach and maintain ketosis, the state where your body burns fat for fuel instead of carbohydrates. Each gummy is loaded with beta-hydroxybutyrate (BHB), a type of exogenous ketone that can jumpstart ketosis and provide your body with a quick energy boost. By taking these gummies regularly, you can enhance your weight loss efforts and improve your overall health.

One of the key benefits of GoKeto BHB Gummies is that they are easy and convenient to take. Unlike traditional BHB supplements that come in powder or pill form, these gummies are tasty and enjoyable to consume. You can simply chew on a gummy whenever you need a quick energy boost or before engaging in physical activity to enhance your performance.

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Many people struggle with fatigue and lack of focus when following a keto diet, especially during the initial stages of transitioning to ketosis. GoKeto BHB Gummies can help combat these common issues by providing your body and brain with a source of clean energy. BHB is known for its ability to enhance mental clarity, focus, and cognitive function, making it easier for you to stay on track with your weight loss journey.

In addition to boosting energy levels, GoKeto BHB Gummies can also help curb your cravings and reduce feelings of hunger. The exogenous ketones in these gummies can suppress appetite and prevent overeating, making it easier for you to stick to your keto diet and avoid sabotaging your progress. Say goodbye to snack cravings and hello to sustainable weight loss with these delicious gummies!

Support Your Weight Loss Goals with GoKeto BHB Gummies

Whether you are new to the keto diet or have been following it for a while, GoKeto BHB Gummies can provide the extra support you need to reach your weight loss goals. These gummies are made with high-quality ingredients and are free from artificial colors, flavors, and preservatives. You can trust that you are giving your body the best possible fuel to succeed on your keto journey.

Don’t let slow progress or lack of energy hold you back from achieving your dream body. Try GoKeto BHB Gummies today and experience the BHB boost you need to take your weight loss journey to the next level!

FAQs

1. How many gummies should I take each day?

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We recommend taking 2-3 gummies per day for optimal results. You can adjust the dosage based on your energy needs and weight loss goals.

2. Are GoKeto BHB Gummies safe to take?

Yes, GoKeto BHB Gummies are made with natural ingredients and are safe for daily consumption. However, we recommend consulting with your healthcare provider before starting any new supplement regimen.

3. Do GoKeto BHB Gummies have any side effects?

While side effects are rare, some people may experience mild digestive issues when first starting to take BHB supplements. These symptoms typically subside as your body adjusts to the increased ketone levels.

4. Can I take GoKeto BHB Gummies if I’m not following a keto diet?

Yes, you can still benefit from taking GoKeto BHB Gummies even if you are not following a strict keto diet. The exogenous ketones in these gummies can help boost your energy levels and support weight loss, regardless of your current diet.

5. Where can I purchase GoKeto BHB Gummies?

You can find GoKeto BHB Gummies on Amazon, where you can take advantage of fast shipping and convenient online ordering. Start your keto journey off right with these delicious and effective gummies!