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(USMLE topics) Methamphetamine: mechanism of action, short-term and long-term effects, addiction and overdose. Purchase a license to download a non-watermarked copy of this video on AlilaMedicalMedia(dot)com ©Alila Medical Media. All rights reserved. Voice by: Ashley Fleming All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Methamphetamine, also called meth or crystal meth, among other names, is a psychostimulant drug mainly known for its recreational use. Methamphetamine is chemically similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder, obesity and narcolepsy; but being more potent and highly addictive, methamphetamine is rarely prescribed for medical treatments. Most commonly, the drug is produced illegally, from pseudoephedrine, an ingredient in cold medicines. It can exist as white powder, pills, or bluish-white crystals, and can be consumed by swallowing, smoking, snorting, or injecting. Methamphetamine acts to increase the amount of a neurotransmitter called dopamine in the brain. Dopamine is at the basis of the brain reward pathway, which is designed to “reward” the body for important behaviors that are essential for survival, such as feeding when hungry. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into a space between neurons, where it binds to and stimulates its receptors on the neighboring neuron. This stimulation is believed to produce pleasurable feelings or rewarding effect. Normally, dopamine molecules are promptly cleared from the synaptic space to ensure that the postsynaptic neurons are not over-stimulated. This is possible thanks to the action of dopamine-transporter, which channels dopamine back to the transmitting neuron. Methamphetamine binds to dopamine-transporter and blocks dopamine re-uptake. In addition, it can enter the transmitting neuron and trigger more dopamine release. The result is that dopamine builds-up in the synapse to a much greater amount than normal. This produces a continuous over-stimulation of receiving neurons and is responsible for the prolonged and intense euphoria experienced by drug users. At a low dose, methamphetamine stimulates the brain and can elevate mood and alertness; and by accelerating heart rate and breathing rate, it increases energy in fatigued individuals. It also reduces appetite and promotes weight loss. These seemingly “positive” effects keep users coming back for more, eventually leading to addiction and potential overdose. Long-term drug users may experience extreme weight loss, severe dental damage, and constant hyperactivity which results in anxiety, sleeping disorders and violent behaviors. Overdose takes the drug’s effects to the extreme and can cause psychosis, heart attacks, seizures, strokes, organ failures, and even death. Currently, there is no approved pharmacological treatment for methamphetamine addiction; the most effective treatments are cognitive behavioral therapies.
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Weight management has always been a significant concern for many individuals, especially those struggling with obesity or overweight issues. While diet and exercise are the cornerstone for achieving weight loss goals, some people may require additional help in the form of medication. Semaglutide, a prescription medication initially developed for managing type 2 diabetes, has shown promising results in aiding weight loss. However, determining the appropriate dosage of Semaglutide for weight loss can be a complex process, requiring careful consideration and monitoring.
Dosing Considerations
When it comes to determining the number of units of Semaglutide for weight loss, several factors need to be taken into account. The dosage of Semaglutide typically varies based on the individual’s weight, medical history, and overall health condition. Additionally, the response to the medication can vary from person to person, so a personalized approach is necessary to achieve optimal results.
Healthcare providers typically start patients on a lower dose of Semaglutide and gradually increase it based on the individual’s response and tolerance to the medication. This stepwise approach helps minimize side effects while allowing the body to adjust to the medication gradually. It is essential to follow the healthcare provider’s guidance and not self-adjust the dosage to prevent any adverse effects.
During the initial weeks of Semaglutide therapy, patients may experience gastrointestinal side effects such as nausea, vomiting, or diarrhea. These side effects are usually temporary and tend to improve as the body adjusts to the medication. If the side effects persist or worsen, it is crucial to consult with the healthcare provider to discuss potential dose adjustments or alternative treatment options.
Monitoring and Adjustment
Regular monitoring is essential when taking Semaglutide for weight loss to assess the effectiveness of the medication and ensure the patient’s safety. Healthcare providers may conduct periodic check-ups, blood tests, and other assessments to monitor weight loss progress, changes in blood sugar levels, and any potential side effects. Based on these observations, adjustments to the dosage of Semaglutide may be necessary to optimize the results.
Patients taking Semaglutide for weight loss should also adopt healthy lifestyle behaviors, including a balanced diet and regular physical activity, to maximize the benefits of the medication. Semaglutide is most effective when used in conjunction with a healthy lifestyle, as it helps reinforce positive habits and promote long-term weight management. It is essential to communicate openly with the healthcare provider about any challenges or barriers faced during the weight loss journey to receive appropriate support and guidance.
Long-Term Maintenance
As patients continue to take Semaglutide for weight loss, long-term maintenance strategies become critical to sustain the results achieved. Consistent follow-up with the healthcare provider is essential to monitor progress, address any concerns, and make necessary adjustments to the treatment plan. Patients should also stay informed about the latest research findings and guidelines related to Semaglutide therapy to make informed decisions about their health.
In conclusion, determining the number of units of Semaglutide for weight loss requires a personalized approach that considers individual factors and involves close monitoring and adjustment. By working collaboratively with healthcare providers and adopting a holistic approach to weight management, patients can maximize the benefits of Semaglutide and achieve long-lasting results in their weight loss journey.
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Health and fitness refer to the overall well-being of the body and mind, achieved through a balanced lifestyle. Health involves maintaining physical, mental, and emotional well-being, while fitness focuses on physical strength, endurance, flexibility, and cardiovascular health. Regular exercise, a nutritious diet, adequate sleep, and stress management are key components of both health and fitness. Together, they help prevent diseases, boost energy, improve mood, and enhance the quality of life.
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💬 Dr Spencer Nadolsky is an obesity and lipid specialist, and an expert in GLP-1 care. He’s also the co-host of the Docs Who Lift podcast. ⚡️In this episode Spencer and I discuss emerging research around weight loss injections tirzepatide and semaglutide, known as Ozempic, Wegovy and Mounjaro - and discuss the proper use of these drugs. 🎧 Stay tuned to find out: ➡︎ Why old restrictions on weight loss drugs are no longer being enforced ➡ How a combo of GLP-1 and GIP may be even more revolutionary for weight loss ➡︎ Why most people have to take these drugs for life ➡︎ Why people get so angry when people lose weight on GLP-1s ➡︎ How GLP-1 drugs are going to make weight-loss surgery extinct 📕 Chapters 0:00 Intro 0:41 The non-weight loss benefits from GLP-1 use 4:55 Getting the dosage right 7:24 Drugs of the future 11:09 How to get started on a weight-loss injection 16:38 Why restrictions on weight loss drugs are being lifted 19:46 Why people get mad about GLP-1 use 23:57 Do you have to take these drugs for life? 27:55 Do fat cells have memory? 29:25 What if you want to stop GLP-1 use? 31:48 The mental health drawbacks of weight loss drugs 35:44 Unique insights from Spencer’s time with patients 38:47 Is excessive muscle loss really a big problem? 42:46 Should everyone be taking GLP-1s? 45:14 Will weight loss surgeries go extinct? 49:11 GLP supplements are a scam 📱 Connect with me: TikTok: https://www.instagram.com/drkaranrajan YouTube: https://www.youtube.com/@DrKaran Instagram: https://www.tiktok.com/@dr.karanr 📱 Connect with Spencer: Instagram: https://www.instagram.com/drnadolsky/ X: https://x.com/DrNadolsky 🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe 🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
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