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Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired, By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that promote insulin secretion and regulate blood glucose levels. Elevated levels of GLP-1 and GIP consequently results in improved glycemic control.6 In clinical trials, vildagliptin has a relatively low risk of hypoglycemia.
Vildagliptin is indicated in the treatment of type II diabetes mellitus in adults. As monotherapy, vildagliptin is indicated in adults inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance. It is also indicated as dual therapy in combination with metformin, a sulphonylurea, or a thiazolidinedione in adults patients with insufficient glycemic control despite maximal tolerated dose of monotherapy.
Vildagliptin is indicated in the treatment of type II diabetes mellitus in adults. As monotherapy, vildagliptin is indicated in adults inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance.6 It is also indicated as dual therapy in combination with metformin, a sulphonylurea, or a thiazolidinedione in adults patients with insufficient glycemic control despite maximal tolerated dose of monotherapy.
Vildagliptin is also marketed in a combination product with metformin for the treatment of adults with type II diabetes mellitus who inadequately respond to either monotherapy of vildagliptin or metformin. This fixed-dose formulation can be used in combination with a sulphonylurea or insulin (i.e., triple therapy) as an adjunct to diet and exercise in adults who do not achieve adequate glycemic control with monotherapy or dual therapy. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones that regulate blood glucose levels and maintain glucose homeostasis. It is estimated that the activity of GLP-1 and GIP contribute more than 70% to the insulin response to an oral glucose challenge. They stimulate insulin secretion in a glucose-dependent manner via G-protein-coupled GIP and GLP-1 receptor signalling. In addition to their effects on insulin secretion, GLP-1 is also involved in promoting islet neogenesis and differentiation, as well as attenuating pancreatic beta-cell apoptosis. Incretin hormones also exert extra-pancreatic effects, such as lipogenesis and myocardial function
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Have you had issues with successfully dieting to lose fat and gain muscle at the same time? Well, it may be due to a few common dieting mistakes that I see people make, which affects their ability to not only lose fat and build muscle (body recomposition) but also keep muscle when dieting in the first place. One of the top dieting mistakes people make is actually losing weight too aggressively. Because when it comes to how to maintain muscle while cutting and even building muscle while losing fat, you need to supply your body with enough energy and nutrients to do so. For example, a well-known 2011 paper found that the group of subjects placed on a ‘fast diet’ (ate 300 fewer calories daily) lost significantly less fat than the slow group, and they also lost a little bit of muscle mass as well. On the other hand, the slow group was actually able to gain a little bit of muscle, gained significantly more strength, and lost a more significant amount of fat as well. So what I’d suggest is to aim to lose around 0.5-1% of your body weight per week, but this does depend on your current level of body fat. The second dieting mistake most people make when wanting to keep or build muscle and lose fat is simply doing too much too soon at the start of the diet. But this approach actually prevents you from having any leverage when you reach a fat loss plateau. When you start dieting and put your body in a calorie deficit, over time, your body compensates by decreasing its metabolism to burn fewer calories. Which eventually leaves you stuck in a fat loss plateau since your metabolism has reduced to the point where you're no longer in a calorie deficit to lose fat. But the problem is, if you’re already starving yourself and doing a ton of cardio, you’re unable to push further to break through this plateau. So instead, for optimal body recomposition, you want to first start at a small to moderate calorie deficit of roughly 10-20% or 500 calories below your maintenance, for example. And you also want to start with minimal cardio, so for instance 1-2 low-intensity sessions per week. Then, as the weeks go by and your weight and fat loss begins to stagnate, you can simply drop your calories further and/or increase your cardio slightly as needed to break through these plateaus every time you reach them. The last mistake when it comes to a diet to how to lose fat without losing muscle is not taking breaks with your calorie deficit. The longer you diet for the more your body begins to physiologically adapt to both slow down your fat loss and make you more prone to losing muscle. To reverse this effect, you can make use of a strategy known as ‘diet break’ where you increase your calories back to maintenance for a week or two during your diet. What I'd recommend for a similar effect is simply implementing a one-week diet break after every 4-8 weeks or so of dieting. This way, you'll avoid increasing the length of your diet too much while still getting the many benefits that diet breaks have to offer. So as you may have noticed guys, when it comes to maintaining your muscle during a diet or how to lose fat and gain muscle at the same time, you need to avoid rushing the process and instead slow it down by using a more controlled and systematic approach. And if you’re looking for a step-by-step program that shows you exactly how to implement this with both your workouts and your nutrition, such that you can lean down while improving your muscle definition and strength, take the analysis quiz below to discover what science-based program best suits you and your starting point: https://builtwithscience.com/bws-free-fitness-quiz/gender?utm_source=Youtube&utm_medium=Video&utm_content=Description%20box&utm_campaign=Lose%20more%20fat%20keep%2Fbuild%20muscle%20Oct%2027%2F2019 Filmed by: Bruno Martin Del Campo MUSIC: Music by Ryan Little - fall so high. - https://thmatc.co/?l=F77E5E72 GRAPHICS: Vecteezy.com bonytobeastly.com FOLLOW ME: https://www.instagram.com/jeremyethier/ https://www.facebook.com/Jeremyethierfit/ STUDIES: FAST DIET VERSUS SLOW DIET https://www.ncbi.nlm.nih.gov/pubmed/21558571?fbclid=IwAR1FeLmsv1o2jidKj2l7aydCTvZF-uKmvxXPRI6sxfUYZCTn7WYFyPeA6U4 https://www.ncbi.nlm.nih.gov/pubmed/10865771?dopt=Abstract https://jissn.biomedcentral.com/articles/10.1186/1550-2783-11-20 DIET BREAK https://www.ncbi.nlm.nih.gov/pubmed/28925405 Subscribe to my channel here: https://www.youtube.com/jeremyethier/?sub_confirmation=1
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¡Hola a todos! Soy Marisa Torcuato y hoy quiero responder a una de las preguntas que más me hacéis: ¿Por qué cuesta tanto perder peso en la menopausia? Recuerda que si quieres un tratamiento personalizado, presencial u online, solo con alimentos y sin tener que pesarlos, puedes contactarme en mi WhatsApp 627026040 o a través del formulario en mi web www.marisatorcuatonutricion.es. ¡No dudes en consultarme cualquier duda! Estoy aquí para ayudarte en tu camino hacia una vida más saludable. Un abrazo y ¡ánimo! #menopausia #menopausiaypeso #menopausiaenforma #menopausiasaludable
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Welcome to my weight loss journey! In this video, I’m sharing how I went from 90 kg to 67 kg in just 2 months—without extreme diets or harsh restrictions. After giving birth, I found myself stuck at 90 kg, feeling frustrated and unsure of how to regain my pre-baby body. But after a year of trying different things, I discovered intermittent fasting, and that’s when everything started to change. In this video, I’ll walk you through my transformation process: The challenges I faced after giving birth. My first attempts at losing weight and why they didn’t work. How I discovered intermittent fasting and why it worked for me. The small lifestyle changes I made, including drinking more water and cutting down on sugary foods, wheat, and fried foods. The results I saw after two months of commitment and consistency. This video isn’t just about weight loss; it’s about finding what works for YOU, being patient with yourself, and taking small steps toward a healthier lifestyle. If you're on your own journey or just starting, I hope my story inspires you to keep going. Don’t forget to like, comment, and subscribe for more updates on my health and fitness journey! #WeightLossJourney #IntermittentFasting #HealthyLifestyle #Transformation #FitnessInspiration
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