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Cancer is one of the greatest Public health challenges worldwide, and in most cases, we still lack of effective anticancer therapies. Nevertheless, There are case reports, in which ketogenic diet have some improvements during variety of cancers. For example, 2 pediatric female patients with brain tumor, experienced improvement after 8 weeks of ketogenic dieting. One of these patients continued the diet and remained disease-free another 12 months. But What connection can have Cancer treatment and Keto diet? CDC estimated that 40% of all cancers are related to overweight and obesity. Cancer is uncontrolled and abnormal cell grow. Such process is not energy efficient. And requires lots of energy. For cancer cells source of energy is glucose. Despite their rapid proliferation, cancer cells use no more oxygen than non-cancer cells for oxidative purposes. Instead, they use about 10 times more glucose and produce about 70 times more lactic acid, than do normal cells. In other words, even with ample oxygen available, most cancer types derive energy from anaerobic glycolysis. This feature is called as Warburg Effect. It is Hallmarks of Cancer. So, Cancer cells consume too much glucose. And cancer fuel is glucose. For humans, The main source of glucose is carbohydrates and proteins. The classic Ketogenic Diet is characterized by high-fat, moderate-to-low protein, and very-low carbohydrate content. This translates into a dietary composition of about 90% fat, 2% carbohydrate, and 8% protein. This ratios varies. But In Keto diets, a ratio between fats and non-fats (carbohydrates + proteins) should be 4:1.; and this process mimics the metabolic effect of starvation. During Keto Diet, liver converts fat into fatty acids then to ketone bodies. So, ketone bodies become, primary source of energy becomes. instead of glucose. Ketogenic diets mimic the fasting state, wherein the body responds to the lack of glucose by producing ketones for energy. Ketogenic diet lowers the level of glucose and insulin in the blood, which are necessary for tumor growth. Thus, the ketogenic diet has emerged as a potential treatment option for a variety of cancers, including breast cancer. This process inhibits aerobic glycolysis and suppresses tumor proliferation, invasion, and migration. So, Keto diet causes to deprive cancer cells of their primary energy source, Glucose. In addition, lack of glucose changes hormonal state of the body and It further interrupts, processes of nutrient sensors which are important for development and proliferation of cancer cells. furthermore, Keto Diet’s beneficial effects have been observed in a range of conditions, including epilepsy and other neurologic diseases, obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease There are concerns about providing protein to patients who are at risk for renal problems. However, mouse models of diabetic nephropathy showed improved renal function with Keto Diet use. Although preclinical studies suggest that Ketogenic Diet has antitumor effects, prolongs survival, and prevents cancer development, human clinical trials are equivocal. Because of the lack of high-quality clinical trials, the effects of ketogenic Diet on cancer and as an adjunctive therapy are essentially unknown. Adverse effects of keto diet. Kidney stones, gout, and symptomatic hypoglycemia were also potential expected adverse effects. By EmmaWiki2020 - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=90978475

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Week 87 Weight Loss Journey & GLP-1 Insights with Laraine & Christopher Durham In this week's episode of 'Downsized Weekly Weigh-In', Laraine and Christopher Durham update viewers on their 87-week weight loss journey using Tirzepatide. Laraine shares her current progress, noting a slight plateau following her recent travels, and details the adjustments to her regimen. Christopher discusses his routine and how he's maintaining his target weight. Viewer comments and questions are addressed, including challenges with Mounjaro availability, the possibility of medical tourism for medication, and concerns about shipping GLP-1 medications. The hosts also mention their excitement for the upcoming Downsized at Sea cruise and promote a charity event supporting cancer research. Tune in for personal experiences, tips, and community support on maintaining a healthy lifestyle using GLP-1 medication. REPLENZA Daily Replenisher: https://amzn.to/3HxigiB REPLENZA Daily Nutritional Supplement: https://amzn.to/4kxCffX Replenza’s free lifestyle guide: https://www.replenzalabs.com/pages/lifestyle-guide 33% off Replenza bundle: https://www.replenzalabs.com/products/replenza-bundle Help Mindy reach her fundraising goal and fight Cancer. The 24th year of 24 Hours of Booty! Hosted by 24 Foundation, this extraordinary 24-hour cycling and walking event unites our community in a powerful celebration of hope, healing and connection. https://events.24foundation.org/fundraiser/6118302 Report a Shortage: https://cdernextgenportal.fda.gov/publicportal/s/dsm-submission DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Welcome to Downsized Weekly Weigh-In 00:14 Our Weight Loss Journeys 00:27 Channel Content Overview 01:30 Weekly Weigh-In: Laraine's Update 02:21 Discussing Tirzepatide Dosages 03:51 Challenges and Adjustments 04:35 The Importance of Tracking 07:55 Exercise and Fitness Goals 09:27 Childhood Fitness Memories 14:30 Weekly Weigh-In: Christopher's Update 15:14 Maintaining Weight Loss 16:56 Flexibility in Dosage and Lifestyle 17:31 Flexible Calorie Management 18:43 Sponsored Segment: Replenza Products 20:16 Evolution of the Show 21:06 Viewer Comments and Questions 25:45 Medical Tourism Discussion 29:47 Upcoming Events and Announcements 32:38 Charity Fundraiser: 24 Hours of Booty 35:27 Closing Remarks and Thank You

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✅To Follow My Weight Loss Journey Please LIKE, SHARE, COMMENT and SUBSCRIBE! LIKE & FOLLOW ❤️Facebook Page! 👉🏾https://www.facebook.com/TLC-With-Keisha-109617468179331 ❤️Instagram 👉🏾@tlcwithkeisha ✅🛒Online Health & Wellness Shop 👉🏾https://linktr.ee/tlcwithkeisha FTC: I receive a small commission from the product links above. I appreciate your support! This is not a sponsored video. All opinions are my own. #WeightLossJourney #gethealthywithme #glp1