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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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Garth Brooks Keto Gummies have been generating a lot of buzz in the health and wellness community lately. With claims of helping people lose weight, boost energy levels, and improve mental clarity, it’s no wonder that these gummies have become so popular. But what exactly is behind the hype? Are Garth Brooks Keto Gummies really as effective as they claim to be? In this article, we will investigate the popularity of these gummies and explore whether they live up to the hype.

Understanding the Ingredients in Garth Brooks Keto Gummies

One of the key factors contributing to the popularity of Garth Brooks Keto Gummies is its powerful blend of ingredients. These gummies are packed with BHB (Beta-Hydroxybutyrate), a ketone body that helps the body enter a state of ketosis. When the body is in ketosis, it burns fat for fuel instead of carbs, leading to weight loss. Additionally, Garth Brooks Keto Gummies contain natural extracts like green tea and Garcinia Cambogia, which are known for their weight loss benefits.

Moreover, these gummies are free from harmful chemicals and additives, making them a safe and healthy option for those looking to improve their overall health. The ingredients in Garth Brooks Keto Gummies work synergistically to support weight loss, increase energy levels, and enhance mental focus, making them a popular choice among health-conscious individuals.

Overall, the carefully selected ingredients in Garth Brooks Keto Gummies play a significant role in their popularity and effectiveness. By understanding the power of these ingredients, it becomes clear why these gummies are in such high demand among consumers seeking a natural and safe way to achieve their health and wellness goals.

The Science Behind Garth Brooks Keto Gummies

Behind the scenes, Garth Brooks Keto Gummies are backed by science to support their claims. The key ingredient, BHB, has been studied for its ability to induce ketosis and promote weight loss. Research has shown that when the body is in ketosis, it burns fat more efficiently, leading to rapid weight loss.

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Furthermore, the natural extracts found in Garth Brooks Keto Gummies have been researched for their weight loss properties. Green tea, for example, has been shown to boost metabolism and promote fat burning. Garcinia Cambogia, on the other hand, has been found to suppress appetite and inhibit the production of fat cells. When combined, these ingredients work together to support weight loss and improve overall health.

With the scientific evidence backing the effectiveness of Garth Brooks Keto Gummies, it’s no wonder that they have gained such a strong following. Consumers can trust that these gummies are not just a passing fad, but a scientifically supported supplement that can help them achieve their health and fitness goals.

The Benefits of Choosing Garth Brooks Keto Gummies

There are numerous benefits to choosing Garth Brooks Keto Gummies as your go-to supplement for weight loss and overall health. One of the most significant advantages of these gummies is their ability to help the body enter ketosis quickly and efficiently. This allows users to experience rapid weight loss and increased energy levels, making it easier to stick to a healthy lifestyle.

Additionally, Garth Brooks Keto Gummies can help suppress appetite, making it easier to control cravings and maintain a healthy diet. The gummies also support mental focus and clarity, helping users stay motivated and productive throughout the day. With these benefits, it’s no surprise that Garth Brooks Keto Gummies have become a popular choice among those looking to improve their health and well-being.

Overall, the benefits of choosing Garth Brooks Keto Gummies are numerous and far-reaching. From weight loss support to increased energy levels, these gummies offer a holistic approach to improving overall health and wellness. By incorporating them into your daily routine, you can experience the many benefits that these gummies have to offer.

Real People, Real Results with Garth Brooks Keto Gummies

One of the most compelling reasons behind the popularity of Garth Brooks Keto Gummies is the real results that people have experienced. Countless individuals have shared their success stories after incorporating these gummies into their daily routine. From significant weight loss to improved energy levels and mental clarity, the proof is in the pudding when it comes to the effectiveness of Garth Brooks Keto Gummies.

Many users have reported feeling more energized and focused throughout the day, enabling them to tackle their daily tasks with ease. Others have seen dramatic changes in their weight and overall body composition, leading to increased confidence and self-esteem. These real-life success stories serve as a testament to the power of Garth Brooks Keto Gummies and why they continue to be a top choice for those seeking a natural and effective way to improve their health.

With so many positive reviews and testimonials, it’s clear that Garth Brooks Keto Gummies are more than just a passing trend – they are a trusted supplement that delivers real results. If you’re looking to transform your health and achieve your weight loss goals, these gummies may be just what you need to jumpstart your journey to a healthier, happier you.

As we have explored in this article, the popularity of Garth Brooks Keto Gummies is backed by a powerful blend of ingredients, scientific evidence, and real-life success stories. These gummies offer a safe and effective way to support weight loss, increase energy levels, and improve overall health. If you’re considering incorporating Garth Brooks Keto Gummies into your routine, be sure to consult with a healthcare professional to ensure they are right for you. With their many benefits and proven track record, these gummies may be just what you need to take your health and wellness to the next level.