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How Do Ozempic and Wegovy Work? Ozempic and Wegovy are synthetic GLP-1 molecules named Semaglutide. Ozempic is approved for type II diabetes mellitus and protection against cardiac events in type II DM patients. Wegovy is approved for weight loss in obese and overweight individuals and for protection against cardiac events in obese and overweight individuals. Let's review the mechanism of action and the side effects of these drugs. If you like this content and want more, click here: https://www.drbeen.com/med-nerd Want to join my uncensored talks? Join me on patreon or substack: Patreon: https://www.patreon.com/mobeensyed?fan_landing=true Substack: https://mobeensyedmd.substack.com/ Want to support this work?: BuyMeACoffee: https://www.buymeacoffee.com/drmobeensyed PayPal: https://paypal.me/mobeensyed?locale.x=en_US #drbeen #koolbeens #Weight_Loss Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight | FDA https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-reduce-risk-serious-heart-problems-specifically-adults-obesity-or Ozempic for weight loss: Does it work, and what do experts recommend? https://health.ucdavis.edu/blog/cultivating-health/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend/2023/07 Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity - PubMed https://pubmed.ncbi.nlm.nih.gov/36511825/ The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology https://www.nature.com/articles/s41575-018-0062-1 Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology https://journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984 Wegovy® Pen Instructions | Wegovy® (semaglutide) Injection 2.4 mg https://www.wegovy.com/taking-wegovy/how-to-use-the-wegovy-pen.html Incretin https://en.wikipedia.org/wiki/Incretin Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms - PubMed https://pubmed.ncbi.nlm.nih.gov/9357836/ Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1 | Diabetes | American Diabetes Association https://diabetesjournals.org/diabetes/article/63/2/407/34120/Give-the-Receptor-a-Brake-Slowing-Gastric-Emptying GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200298/#:~:text=For%20instance%2C%20proglucagon%20is%20cleaved,13%2C%2016%2C%2027). What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218725/ Glucagon-Like Peptide-1 Receptor Agonists for Chronic Weight Management - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533252/ Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology https://journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984 Why Ozempic Causes Diarrhea and How to Manage Your Symptoms - GoodRx https://www.goodrx.com/ozempic/diarrhea Wegovy (Semaglutide): Uses, Side Effects & Weight Loss https://www.drugwatch.com/drugs/wegovy/#:~:text=Wegovy%20carries%20a%20black%20box,same%20effects%20occur%20in%20humans. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss | Gastroenterology | JAMA | JAMA Network https://jamanetwork.com/journals/jama/fullarticle/2810542 The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology https://www.nature.com/articles/s41575-018-0062-1 What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218725/ Enteroendocrine cell - Wikipedia https://en.wikipedia.org/wiki/Enteroendocrine_cell#:~:text=in%20the%20duodenum.-,L%20cell,in%20the%20duodenum%20and%20jejunum. What is ilial brake? inslag.indd https://scholarlypublications.universiteitleiden.nl/access/item%3A2956466/view Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483000/#:~:text=Distinct%20neuronal%20cell%20populations%2C%20particularly,glucose%20metabolism%20and%20energy%20expenditure.

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Subscribe: https://youtube.com/@drtyna On this quick-and-dirty solo episode, I'm diving into a brand-new article just published in Diabetes Care (March 2025, Vol. 48): "One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes and Multi-Dose Pens." This opinion piece by respected endocrinologists signals a massive shift in the conversation—one I’ve been screaming from the rooftops for over a year. While I’m not claiming credit (ok maybe a little), I am thrilled to see microdosing GLP-1s being acknowledged by mainstream medicine… even if they’re still getting a lot of it, well, OFF. Let’s be clear: microdosing was NEVER meant to be a weight loss strategy, even thought that’s what everyone seems to think it’s for. And if you’re NOT using these drugs without a full metabolic support plan—protein, lifting, hormones, insulin sensitivity—you’re setting yourself (or your patients) up to fail. _____________________________________________________________________________________________ Social & Website:  Instagram -  https://www.instagram.com/drtyna/   Website - https://www.drtyna.com/ Store - https://store.drtyna.com/ Courses - https://www.drtyna.com/store  Metabolic Revamp Toolkit: https://bit.ly/drtynametabolicrevamp FREE GUIDE: Assess Your Metabolic Health: https://www.drtyna.com/metabolism GLP1's Uncovered FREE 4 Part Video Series https://www.drtyna.com/ozempicuncovered Subscribe to The Dr. Tyna Show: Apple Podcasts: https://apple.co/4bm3R3m Spotify: https://spoti.fi/3OtOps7 Substack: https://drtyna.substack.com/ _____________________________________________________________________________________________ On This Episode We Cover: 00:00:00 - Introduction & Milestone 00:02:45 - Ozempic: Weight Loss & Dosing 00:10:28 - Semaglutide Research Highlights 00:14:12 - Pen-Click Microdosing Method 00:16:06 - GLP-1s in Treatment Plans _____________________________________________________________________________________________ Further Listening: GLP1s Uncovered FREE 4 Part Video Series https://www.drtyna.com/ozempicuncovered _____________________________________________________________________________________________ Show Links: One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens https://pubmed.ncbi.nlm.nih.gov/39808463/ _____________________________________________________________________________________________ Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

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