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Welcome to our discussion on GLP-1 medication in the context of their weight loss licensing. All medication comes with risk, but as this class of medication has many benefits, including aesthetics, we believe many people have lost touch with the fact that these are regulated medication. We have became aware of online communities providing medical advice for GLP-1 medication, this is highly dangerous and this should not be a primary source of information and should be discussed with your healthcare team. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading. If you would like to go to a particular section, please click on the time stamp below (please note this podcast was extremely hard to time stamp, so we did our best): 00:08 - Why are we discussing GLP-1 medications again? 01:54 - Online weight-loss communities are more detrimental than good 09:58 - How is medication regulated in the UK? 16:32 - Are online pharmacies helping the situation? 20:34 - GLP-1 medication does require you to adopt a healthy lifestyle 21:58 - The controversial aspects of health? 28:52 - Social media versus health care professionals 29:58 - Let’s discuss ‘Big Pharma’ 33:08 - Our final thoughts and key points Here is our podcast link: https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA Sign up to our newsletter: https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening! Here is a list of the sources that we used to make this podcast: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 https://www.nejm.org/doi/full/10.1056/NEJMoa1411892 https://www.nejm.org/doi/10.1056/NEJMoa2032183?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Rang & Dale’s Pharmacology 10th edition - general pharmacological overview
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Learn more at Penn Medical Group: https://pennmedicalgroup.com/ or call us at (610) 321-7777 for a free consultation.
Semaglutide is a medication that was originally developed for the treatment of type 2 diabetes. It is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the action of GLP-1, a hormone that helps regulate blood sugar levels. GLP-1 receptor agonists work by increasing insulin secretion, decreasing glucagon secretion (a hormone that increases blood sugar), and slowing gastric emptying.
In addition to its effects on blood sugar regulation, semaglutide has been observed to reduce appetite and promote weight loss. This weight loss effect led to investigations and clinical trials on its potential as a weight management drug.
By 2021, based on the outcomes of these trials, the U.S. Food and Drug Administration (FDA) approved a higher-dose formulation of semaglutide (specifically marketed under the brand name "Wegovy") for chronic weight management in adults with obesity or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. This was in addition to a reduced-calorie diet and increased physical activity.
It's worth noting that while semaglutide can promote significant weight loss in some individuals, it is not a miracle cure for obesity. Weight loss results can vary among individuals, and the drug must be used under the guidance and supervision of a healthcare professional. There can also be side effects, and it's important to discuss these with a healthcare provider before starting the medication.
