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(30 Jan 2025) RESTRICTION SUMMARY: ASSOCIATED PRESS ARCHIVE: Hillerod, Denmark - 26 September 2023 1. Various of diabetes drug Ozempic going through automated packaging line at Novo Nordisk production facility ASSOCIATED PRESS Coral Gables, Florida – 28 January 2025 2. SOUNDBITE (English) Irina Dumitrescu, survey respondent: "I strongly feel that it should be under the supervision of a medical professional and, you know, prescribed." ASSOCIATED PRESS ARCHIVE: Temecula, California – 30 April 2024 3. STILL: Wegovy injectable pens ASSOCIATED PRESS ARCHIVE: Chicago – 20 January 2010 4. STILL: A subject's waist is measured during an obesity prevention study ASSOCIATED PRESS ARCHIVE: Front Royal, Virginia – 1 March 2024 5. STILL Donna Cooper holds up a dosage of Wegovy, a drug used for weight loss, at her home 6. STILL Doses of Wegovy, a drug used for weight loss, are stored in a refrigerator ASSOCIATED PRESS ARCHIVE: Temecula, California – 30 April 2024 7. STILL Stack of Wegovy boxes ASSOCIATED PRESS St. Louis, Missouri – 27 January 2025 8.SOUNDBITE (English) Dr. Kai Jones, Washington University School of Medicine "There's, you know, varied in terms of which private insurance companies cover it and formularies change where medications are covered and they're no longer covered. And that's something we really have to counsel folks about because we know that stopping these medications can often lead to weight regain." ASSOCIATED PRESS ARCHIVE: St. Petersburg, Florida – 7 November 2023 9. Kelly Burns, tirzepatide clinical trial participant, cooks behind an injectable pen of tirzepatide 10. Closeup of vegetable being chopped ASSOCIATED PRESS St. Louis, Missouri – 27 January 2025 11. SOUNDBITE (English) Dr. Kai Jones, Washington University School of Medicine: ++PARTIALLY COVERED++ "And some folks may associate these medications with only weight loss or only those things and not know that they have approval for other medical co-morbidities that are very impactful for people's lives." ASSOCIATED PRESS ARCHIVE: St. Petersburg, Florida – 7 November 2023 12. Various Burns walking down the street for exercise STORYLINE: GLP-1 AGONISTS, COMMONLY REFERRED TO AS WEIGHT-LOSS DRUGS, HAVE SOARED IN POPULARITY IN RECENT YEARS. BUT WHAT DO PEOPLE KNOW AND THINK ABOUT THEM? A NEW POLL FROM THE ASSOCIATED PRESS-NORC CENTER FOR PUBLIC AFFAIRS RESEARCH FINDS THAT ABOUT HALF OF U.S. ADULTS SAY IT’S “VERY GOOD” OR “SOMEWHAT GOOD” FOR ADULTS TO USE WEIGHT-LOSS DRUGS IF THEY ARE STRUGGLING WITH OBESITY OR A WEIGHT-RELATED HEALTH CONDITION. PEOPLE ARE MORE HESITANT WHEN IT COMES TO PRESCRIBING DRUGS TO YOUNGER PEOPLE AGES 12 TO 18, EVEN IF THEY’RE DEALING WITH OBESITY OR A WEIGHT-RELATED CONDITION, AND MOST AMERICANS DON’T THINK IT’S A GOOD IDEA FOR THESE DRUGS TO BE USED TO LOSE WEIGHT IF A PERSON ISN’T OBESE. SOUNDBITE (English) Irina Dumitrescu, survey respondent "I strongly feel that it should be under the supervision of a medical professional and, you know, prescribed." ABOUT HALF OF AMERICANS ALSO FAVOR MEDICAID AND MEDICARE COVERING WEIGHT LOSS DRUG PRESCRIPTIONS FOR PEOPLE WITH OBESITY. CURRENTLY, COVERAGE IN THE U.S. OF THESE DRUGS REMAINS SCATTERED. SOME LARGE COMPANIES AND MEDICAID PROGRAMS ARE ADDING COVERAGE. BUT MANY OTHER EMPLOYERS AND HEALTH INSURERS ARE SCALING BACK, AND MEDICARE DOESN’T COVER THE DRUGS AT ALL. SOUNDBITE (English) Dr. Kai Jones, Washington University School of Medicine EXPERTS ALSO WANT PEOPLE TO UNDERSTAND THAT OBESITY CAN BE COMPLICATED TO TREAT, AND THAT THESE DRUGS CAN HAVE OTHER IMPACTS AS WELL. Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives ​​ Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/31aa5baa1f8e427b827ba1d711b5b911

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Genre: Romantic comedy. 12+ Length: 102 min Directed by: Alexey Nuzhniy Starring: Alexandra Bortich, Evgueni Kulik, Irina Gorbatcheva, Sergei Shnurov. Anna’s life is consumed by two passions: her athletic boyfriend Zhenya, and food. However, it is because of her love of food that Zhenya leaves her for a more attractive young model, whilst Anya goes on a spiral of self-loathing. It is a good thing though, that she has friends and enlists her fellow food-lover Nick to help her lose weight in return for love and happiness. Anya is determined to get her boyfriend back and so she encounters all manner of strange obstacles and unexpected discoveries. This is a delightful romantic comedy not only about the difficulties of losing weight, but of staying true to oneself with terrific, heartfelt performances by Bortich, Kulik, Gorbacheva and Shnurov. Unlike other makeover film narratives, acclaimed comedy director Alexei Nuzhnyi presents a sophisticated view of the changes required for happiness and they are far from skin deep.

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Pfizer's Bold Move into the Weight Loss Market: Oral GLP-1 Medications In this episode of 'The Downsized,' host Christopher Durham delves into Pfizer's latest efforts to enter the competitive weight loss market, focusing on the development of oral GLP-1 medications. As Pfizer prepares to challenge industry leaders Novo Nordisk and Eli Lilly, Durham reviews the company's Q3 earnings call and their unveiling of three new drug candidates. Emphasizing the potential impact of oral options on patient accessibility and treatment costs, the episode also explains the roles of GLP-1 and GIP in weight loss and diabetes management. Highlighting Pfizer's strategic advantage, Durham discusses how these innovative treatments could drive market competition and make life-changing medications more affordable and accessible. The episode concludes with a hopeful perspective on the evolving landscape of obesity treatment and encourages viewers to stay informed through the channel’s updates. DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction 01:10 Pfizer's Ambitious Plans for Weight Loss Market 03:04 Understanding GLP-1 and GIP Hormones 04:26 Pfizer's Latest Developments and Drug Candidates 07:23 Impact on Obesity Treatment and Market Competition 11:36 Financial Performance and Market Potential 13:12 Conclusion and Future Outlook

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