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GLP-1 (Glucagon-Like Peptide-1) inhibitors, more accurately known as GLP-1 receptor agonists, are a class of medications primarily used to treat type 2 diabetes and obesity. Here's a comprehensive look at what they are, how they work, their benefits, and considerations: How They Work: Mimicking GLP-1: GLP-1 receptor agonists mimic the function of the GLP-1 hormone, which is naturally released in the gut in response to food intake. They stimulate insulin secretion from the pancreas when blood glucose levels are high, suppress glucagon release (which would normally increase blood glucose), slow gastric emptying, and increase satiety signals to the brain. Mechanisms: Insulin Release: They help the body release insulin more effectively in response to meals. Glucagon Inhibition: They reduce the amount of glucagon, which helps lower blood sugar. Gastric Emptying: By slowing how quickly food leaves the stomach, they control post-meal blood sugar spikes. Appetite Suppression: They signal to the brain to reduce food intake, aiding in weight management. Benefits: Blood Sugar Control: Effective in lowering HbA1c levels, managing blood sugar in type 2 diabetes. Weight Loss: They have been shown to reduce appetite and body weight, making them useful for obesity management. Cardiovascular and Renal Benefits: Some GLP-1 receptor agonists have demonstrated benefits in reducing cardiovascular risks and improving renal outcomes in diabetic patients. Common Medications: Semaglutide (Ozempic for diabetes, Wegovy for weight loss) Liraglutide (Victoza for diabetes, Saxenda for weight loss) Dulaglutide (Trulicity) Exenatide (Byetta, Bydureon) Tirzepatide (Mounjaro, Zepbound) - a dual agonist that also targets GIP receptor. Side Effects: Gastrointestinal Issues: Nausea, vomiting, diarrhea, and constipation are common, especially when starting treatment. Ozempic Face: Rapid weight loss can lead to sagging skin on the face. Other Side Effects: Less common but more serious side effects include pancreatitis or potential thyroid tumors. Considerations: Administration: Most are injectable, though there's an oral semaglutide option. Cost: These medications can be expensive, potentially limiting access. Off-label Use: There's growing off-label use for weight loss, which brings up debates on ethics, safety, and long-term effects. Insurance and Coverage: Coverage can be variable, with some insurance plans not covering these drugs for weight loss unless certain criteria are met. Long-term Effects: While effective, the long-term effects are still under study, especially with the newer drugs and higher doses used for weight loss. Current Developments: Research: There's ongoing research into their use for other conditions like non-alcoholic fatty liver disease and polycystic ovary syndrome. Market Impact: The popularity of these drugs has significantly influenced the pharmaceutical market, with companies like Novo Nordisk and Eli Lilly seeing substantial growth due to these medications. In summary, GLP-1 receptor agonists represent a significant advancement in managing type 2 diabetes and obesity, offering multiple health benefits alongside some considerations regarding side effects, costs, and ethical use.

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In this video I'm going to talk about how to Lose Weight WITHOUT Dieting! It's very difficult to lose even half a kilo of body fat without changing your diet. If you eat junk food, you’ll have to burn even more calories to burn extra fat. Weight loss is 15% exercise and 85% diet! You have to change your diet if you want to lose weight. There’s no way around it! Exercise improves fitness, muscle tone, and health, but it is not the key to weight loss and certainly won’t help you lose weight fast. If you want to lose fat and not just water weight, you have to keep insulin low. Decreasing insulin will also decrease your appetite and cravings. To reduce insulin, you must go on a low-carb diet! The carnivore diet involves eliminating all carbohydrates and eating meat, eggs, fish, and cheese. This simple diet can help you lose weight fast! Intermittent fasting is the key to fat loss. It can also help with other health problems, such as inflammation, high blood pressure, diabetes, and depression. Remember, carbs block fat burning. You can lose weight without changing your diet, but it won't be much! DISCLAIMER: This video is purely educational and cannot be considered as personal medical advice. The content is my personal opinion and not that of my employer(s). Use this information at your own risk. I will not assume any liability for any direct or indirect losses or damages that may result from the use of the information contained in this video including but not limited to economic loss, injury, illness, or death.

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