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**GLP-1 News | May 5 — WHO Backs GLP-1s, Lilly Hits \$6B, CVS Picks Wegovy, and More** Welcome to *The Downsized News*, your trusted source for real updates, honest analysis, and patient-first reporting about GLP-1 medications like Zepbound, Mounjaro, Wegovy, Ozempic, and semaglutide. In this episode, Christopher and Laraine Durham—who’ve lost more than 150 pounds combined using GLP-1s—bring you the latest headlines and why they matter for real people using these medications to treat the disease of obesity. Here’s what we’re covering this week: * **The World Health Organization (WHO)** is officially backing GLP-1s for the treatment of obesity in adults. This is a major turning point—but they also warn that cost and access remain global barriers. We break down what this could mean for the future of coverage and generics. * **CVS Caremark’s Big Move**: Starting July 1, Wegovy becomes the preferred GLP-1 on CVS Caremark’s formularies. That could create new access for some—and new roadblocks for others using Zepbound or Mounjaro. We explain how PBMs work and what this decision really means for patients. * **Eli Lilly’s Q1 2025 Earnings**: Lilly just posted over \$6 billion in GLP-1 sales. Zepbound and Mounjaro are dominating the market—and their oral GLP-1 pill, orforglipron, is showing promising results in trials. We discuss the financials, the future pipeline, and what it means for self-pay patients. * **Novo Nordisk & Telehealth Twist**: In a surprising turn, Novo Nordisk has partnered with Hims & Hers, Ro, and LifeMD—platforms they previously warned against. We explore why they made the deal, how the shortage ruling changed everything, and what this means for access and control. * **Research into GLP-1 Effectiveness**: Illumina and Ovation.io are launching the largest-ever study to understand why some people respond to GLP-1s—and others don’t. This kind of research could unlock personalized obesity treatment in the future. * **GLP-1s and Heart Health**: The American Heart Association is funding seven studies to explore how these medications reduce cardiovascular risk, and why not everyone sees the same benefits. It’s a big step toward more tailored care for people with obesity. * **GLP-1s and Liver Disease**: New clinical trial results show semaglutide could help patients with MASH, a serious liver disease tied to obesity. Wegovy is now under FDA review for this indication. * **Oral Semaglutide for Obesity**: The FDA has accepted Novo Nordisk’s application for a once-daily oral version of Wegovy. A decision is expected in late 2025, and it could be a game-changer for people looking for a non-injectable option. At *The Downsized*, we’re not doctors—we’re patients sharing our experience and the latest information to help you stay informed on your GLP-1 adventure. Always talk to your healthcare provider before starting or changing your treatment. DOWNSIZED WEBSITE: https://thedownsized.org/ DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store JOIN CLUB DOWNSIZED: @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Lilly's $6 Billion GLP-1 Bombshell—and What Comes Next 01:23 WHO Endorses GLP-1s for Obesity 07:56 Eli Lilly's Blockbuster Quarter and Future Innovations 12:21 Novo Nordisk Partners with Telehealth Companies 15:21 Research into GLP-1 Effectiveness 19:20 American Heart Association's GLP-1 Research Grants 23:38 Semaglutide's Potential for Treating Liver Disease 28:08 Conclusion and Wrap-Up
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Baja Slim Keto Gummies are making waves in the health and wellness industry as a convenient and effective way to support weight loss goals. Designed for individuals seeking a simpler approach to achieving ketosis, these gummies promise a flavorful and hassle-free way to shed excess pounds. Let’s delve into what makes Baja Slim Keto Gummies stand out.
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Weight loss pills have become a popular option for individuals looking to shed extra pounds without putting in the effort of dieting or exercising. With claims of quick and easy weight loss, it’s no wonder that many people are turning to these “magic” pills as a solution to their weight loss struggles. But can you really lose weight without working out by simply taking a pill?
Understanding No Exercise Weight Loss Pills
Before delving into whether or not weight loss pills can help you lose weight without working out, it’s important to understand how these pills work. There are different types of weight loss pills available on the market, each with its own mechanism of action. Some pills work by suppressing appetite, while others work by increasing metabolism or blocking the absorption of fat. It’s essential to do thorough research and consult with a healthcare provider before starting any weight loss pill regimen.
Additionally, it’s crucial to note that weight loss pills are not regulated by the FDA in the same way that prescription medications are. This means that the safety and efficacy of these pills may not be guaranteed. Some weight loss pills may contain harmful ingredients or have adverse side effects, so it’s essential to be cautious when choosing a weight loss pill.
While weight loss pills may seem like a convenient solution for those who want to lose weight without putting in the effort, it’s essential to remember that there is no magic solution to weight loss. To achieve long-term, sustainable weight loss, a combination of a healthy diet and regular exercise is key. Weight loss pills should be used as a supplement to a healthy lifestyle, not as a replacement for it.
Myth vs. Reality: Can You Lose Weight Without Working Out?
One common misconception is that weight loss pills can help you lose weight without working out. While some weight loss pills may aid in weight loss by suppressing appetite or increasing metabolism, they are not a substitute for regular exercise. Exercise is essential for overall health and well-being, as it helps to improve cardiovascular health, increase muscle mass, and boost metabolism.
Additionally, relying solely on weight loss pills to lose weight can have negative consequences. Without making lifestyle changes such as adopting a healthy diet and incorporating exercise into your routine, it’s unlikely that you will achieve long-term weight loss success. Weight loss pills should be used in conjunction with a healthy lifestyle to maximize their effectiveness and ensure safe and sustainable weight loss.
Ultimately, while weight loss pills may offer some benefits in aiding weight loss, they should not be relied upon as the sole method of losing weight. To achieve lasting results, a holistic approach that includes a healthy diet, regular exercise, and lifestyle changes is necessary.
Considerations Before Trying No Exercise Weight Loss Pills
Before trying any weight loss pill, it’s essential to consider a few key factors. First and foremost, consult with a healthcare provider or a registered dietitian to discuss your weight loss goals and determine if a weight loss pill is a suitable option for you. Your healthcare provider can help you navigate the potential risks and benefits of weight loss pills and create a personalized plan that aligns with your health needs.
Additionally, do thorough research on the different types of weight loss pills available and choose a reputable brand with positive reviews and a proven track record of safety and efficacy. Be wary of weight loss pills that make unrealistic promises or have questionable ingredients, and always follow the recommended dosage instructions to avoid adverse side effects.
Remember that weight loss pills are not a quick fix or a miracle solution for weight loss. To achieve sustainable weight loss, it’s essential to make lasting lifestyle changes that promote overall health and well-being. While weight loss pills may offer some support in your weight loss journey, they should be used in conjunction with a healthy diet and regular exercise for optimal results.
Conclusion
While weight loss pills may provide some benefits in aiding weight loss, they are not a substitute for diet and exercise. To achieve long-term, sustainable weight loss, it’s crucial to adopt a healthy lifestyle that includes a balanced diet, regular exercise, and positive lifestyle changes. Weight loss pills should be used as a supplement to a healthy lifestyle, not as a replacement for it. Always consult with a healthcare provider before starting any weight loss pill regimen to ensure your safety and well-being.
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The ketogenic diet has gained immense popularity in recent years for its ability to help people lose weight, improve health, and increase energy levels. By drastically reducing carbohydrate intake and replacing it with fats, the body enters a state of ketosis, where it burns fat for fuel instead of glucose. However, some individuals may find it challenging to maintain ketosis or experience optimal results. This is where combining ketosis with apple cider vinegar (ACV) can enhance the benefits and make it easier to achieve your health goals.
Enhanced Fat Burning
When following a ketogenic diet, the body produces ketones as a byproduct of burning fat for fuel. Ketones are an efficient source of energy and can help increase metabolism, leading to enhanced fat burning. Apple cider vinegar has been shown to increase the production of ketone bodies, making it easier for the body to stay in ketosis and burn fat more effectively.
ACV contains acetic acid, which has been found to improve insulin sensitivity and reduce blood sugar levels. By stabilizing blood sugar and insulin levels, ACV can help prevent spikes and crashes that can lead to cravings and sabotage your weight loss efforts. When combined with the ketogenic diet, ACV can further enhance fat burning and support weight loss.
Additionally, apple cider vinegar has been shown to increase feelings of fullness and reduce appetite, which can help prevent overeating and promote weight loss. By incorporating ACV into your ketogenic lifestyle, you can experience greater satiety and control cravings, making it easier to stick to your diet and achieve your desired results.
Improved Digestion
Another benefit of combining ketosis and apple cider vinegar is improved digestion. The high fat content of the ketogenic diet can sometimes lead to digestive issues such as constipation or bloating. ACV can help alleviate these symptoms by promoting the production of digestive enzymes and supporting gut health.
Apple cider vinegar contains beneficial bacteria that can help restore the natural balance of your gut microbiome, which is essential for proper digestion and nutrient absorption. By incorporating ACV into your ketogenic diet, you can support a healthy gut and ensure that your digestive system is functioning optimally.
Furthermore, ACV has been shown to help with indigestion and heartburn by increasing stomach acid production and promoting proper digestion. By improving digestion, ACV can help alleviate discomfort and ensure that your body is able to effectively utilize the nutrients from your keto-friendly meals.
Enhanced Detoxification
In addition to its benefits for fat burning and digestion, combining ketosis with apple cider vinegar can also support detoxification. ACV has powerful antioxidant properties that can help neutralize free radicals and protect cells from damage. This can be especially beneficial when following a ketogenic diet, as the body may produce more free radicals during the process of burning fat for fuel.
By incorporating ACV into your ketogenic lifestyle, you can support the body’s natural detoxification processes and promote overall health and well-being. Apple cider vinegar can help cleanse the liver, improve lymphatic function, and support the body’s ability to eliminate toxins, making it a valuable addition to your ketogenic regimen.
Furthermore, ACV has been found to support kidney health by helping to prevent the formation of kidney stones and promoting proper kidney function. By including ACV in your ketogenic diet, you can support detoxification pathways and ensure that your body is able to efficiently remove waste products and toxins.
Improved Energy Levels
One of the key benefits of combining ketosis and apple cider vinegar is improved energy levels. When following a ketogenic diet, the body transitions from using glucose as its primary fuel source to using ketones, which can provide a more stable and long-lasting source of energy. By incorporating ACV into your ketogenic lifestyle, you can further enhance energy production and support optimal performance.
Apple cider vinegar has been shown to increase mitochondrial function, which are the energy-producing units in your cells. By improving mitochondrial function, ACV can help enhance energy production and reduce fatigue, allowing you to feel more energized and focused throughout the day. This can be especially beneficial for individuals who may experience dips in energy while following a ketogenic diet.
Additionally, ACV can help reduce lactic acid build-up in the muscles and improve exercise performance. By including ACV in your ketogenic regimen, you can support physical performance and endurance, making it easier to stay active and reach your fitness goals. The combination of ketosis and apple cider vinegar can help you feel more energetic, motivated, and focused as you work towards achieving optimal health and well-being.
Summary and FAQ
In conclusion, combining ketosis with apple cider vinegar can enhance the benefits of both and make it easier to achieve your health and weight loss goals. By improving fat burning, digestion, detoxification, and energy levels, the synergy between ketosis and ACV can support overall health and well-being. If you’re looking to optimize your ketogenic lifestyle and experience greater results, consider incorporating apple cider vinegar into your daily routine.
Here are some frequently asked questions about Keto Plus ACV:
Q: How much apple cider vinegar should I consume daily for optimal results?
A: The recommended dosage of apple cider vinegar can vary, but a common recommendation is to start with 1-2 tablespoons diluted in water before meals. It’s best to listen to your body and adjust the dosage based on your individual needs and goals.
Q: Can I take apple cider vinegar supplements instead of liquid ACV?
A: While apple cider vinegar supplements can be convenient, it’s important to choose high-quality options that contain the same beneficial compounds as liquid ACV. Be sure to follow the recommended dosage and consult with a healthcare provider before taking any new supplements.
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Q: Are there any side effects of combining ketosis and apple cider vinegar?
A: Some individuals may experience mild side effects such as digestive discomfort or throat irritation when consuming apple cider vinegar. It’s important to start with a small amount and gradually increase the dosage to minimize any potential side effects. If you have any concerns, consult with a healthcare provider before adding ACV to your ketogenic regimen.
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Seems like the entire fitness influencer community is all hyped up for incline walking these days, but they're missing one crucial piece of the puzzle. And if you actually want to get lean without wasting time on trendy half-truths, here’s what you need to know. Yes, when you exercise at a higher intensity your body will utilize more carbs since they're a faster acting energy source. It's also true that when you exercise at a lower intensity, fat becomes the primary fuel because your body has more time to mobilize it. But what most people - including a lot of fitness coaches - don't understand is that overall fat loss isn’t about which specific fuel you use during a workout -- it’s about total calories burned for the day as a whole. See, your body isn’t stupid. It's a very tightly regulated system that constantly adjusts fuel sources throughout the day to keep things in balance. Meaning that if you burn more fat during training, you'll just burn more carbs later on. And if you burn more carbs during training, you can probably guess what happens, you'll burn more fat afterwards. Don't get me wrong, incline walking is great and I do plenty of it myself. However, it's not some kind of special fat loss hack like everyone's making it out to be, other forms of cardio are perfectly fine depending on what you prefer, and if you do want to mix in some higher intensity varieties, all those calories still count toward your fat loss goal. The only "zone" you actually need to be in if you want to get leaner is a calorie deficit. #fitness #gym #workout #buildmuscle #bodybuilding
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