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GLP1 drugs are highly effective at weight loss, but it comes at a cost. The approach requires expertise and oversight from an expert. There are several strategies that can help prevent or manage muscle mass loss associated with GLP-1 agonist treatment: ## Resistance Training Incorporating resistance or strength training exercises is one of the most effective ways to preserve and build muscle mass during weight loss[1][2]. This counteracts the catabolic effects of caloric deficit by stimulating muscle protein synthesis. ## Adequate Protein Intake Ensuring sufficient dietary protein intake, ideally 1.6-2.2 g/kg of ideal body weight per day, can help minimize muscle loss[2]. Protein provides amino acids needed for muscle maintenance and repair. ## Combining with Myostatin Inhibitors Myostatin is a key negative regulator of muscle growth. Blocking myostatin with investigational drugs like apitegromab (SRK-439) from Scholar Rock may enhance muscle growth and prevent muscle loss when combined with GLP-1 agonists[1]. Early clinical trials are underway to test this approach. ## Using Activin Receptor Inhibitors Activin receptor inhibitors like those being developed by companies like Regeneron can block activin signaling and potentially increase muscle mass when used alongside GLP-1 medications[3]. ## mTOR Activators The mTOR pathway regulates muscle protein synthesis. Drugs that activate mTOR, such as the PPAR agonist enobosarm being tested by Veru, may preserve muscle when combined with GLP-1 treatment[5]. ## Adequate Vitamin D and Calcium Ensuring sufficient vitamin D and calcium intake is important for preserving bone mineral density, which can be impacted by the weight loss and muscle loss induced by GLP-1 agonists[2]. The key is utilizing a multi-modal approach combining GLP-1 agonists with resistance exercise, optimal nutrition, and emerging muscle-preserving medications to maximize fat loss while minimizing the loss of metabolically active lean muscle mass[1][2][3]. Citations: [1] https://pharmanewsintel.com/features/addressing-muscle-loss-associated-with-glp-1-medication-use [2] https://www.medscape.com/viewarticle/994030 [3] https://www.tctmd.com/news/dont-worry-about-muscle-loss-glp-1-inhibitors-viewpoint-asserts [4] https://www.uclahealth.org/news/article/rapid-weight-loss-can-lead-loss-muscle-mass [5] https://www.drugdiscoverytrends.com/glp-1-impact-lean-mass/
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GLP-1 Myth #5: They Cause Pancreatitis Group Coaching Call Waitlist👉https://floridaconciergemed.com/groupcoachingcallwaitlist Dr. Gerard Acloque Jr., MD Hollywood, FL This channel (Florida Concierge Medicine & Wellness/Dr. Gerard Acloque), its content, and the opinions expressed by Dr. G are intended for informational purposes only and do not constitute medical advice. The content provided on this channel, including videos, comments, and other materials, is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified and trusted health provider with any questions you may have regarding any medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read on this channel. Reliance on any information provided by this channel is solely at your own risk.
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In this episode, we’re diving into the challenges—and opportunities—of navigating the holiday season while on GLP-1 medications (Ozempic, Wegovy, Semalgutide, Mounjaro, Zepbound, and Tirzepatide). The holidays can be a tough time to stay focused on health goals, especially with all the delicious food, social gatherings, and traditions that revolve around indulgence. But staying on track doesn’t mean missing out on the festivities! We’ll share practical tips for making mindful choices, strategies for managing cravings, and how to stay motivated without feeling restricted. Join us as we explore how to enjoy the holiday season without compromising your progress. Whether it’s rethinking portion sizes, choosing the best foods to prioritize, traveling with your meds, or finding ways to stay active, we’ve got your back with doable tips and motivation to make this a successful season for both health and happiness.
