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Orforglipron also reduced blood sugar levels in participants with type 2 diabetes A significant trial of a daily weight-loss pill has found that it helped people to shed the pounds and reduce their blood sugar levels, making it a contender to join the new wave of drugs that combat obesity and diabetes. People who took a 36mg pill of orforglipron lost an average of 7.3kg (16lbs) over nine months, according to results from a phase 3 clinical trial reported by the drug’s manufacturer, Eli Lilly, on Thursday. The trial, which enrolled 559 obese people with type 2 diabetes from the US, China, India, Japan and Mexico, also found that the daily pill reduced blood sugar levels, in some cases bringing them below the formal threshold for diabetes. Results from the trial have been eagerly awaited by health researchers. Orforglipron is a daily pill version of a GLP-1 agonist, the medication used in blockbuster weight-loss injections such as Ozempic and Wegovy. David Ricks, Eli Lilly’s chief executive, said: “As a convenient once-daily pill, orforglipron may provide a new option and, if approved, could be readily manufactured and launched at scale for use by people around the world.” In a statement accompanying the results, the company said the drug met expectations on safety, tolerability, glucose control and weight loss. While weight-loss jabs have soared in popularity, health officials believe that daily pill versions of the medicine could allow more people to control their weight and blood sugar levels. In Britain, two-thirds of adults are either overweight or living with obesity and more than 5 million people have type 2 diabetes. The 40-week trial showed that taking a daily pill of 3mg, 12mg or 36mg reduced blood sugar by 1.2% to 1.5%. During the same period, participants saw their weight drop by an average of 4.5% on the 3mg pill, 5.8% on the 12mg pill and 7.6% on the 36mg pill. The results will be presented at a meeting of the American Diabetes Association in June before publication in a peer-reviewed journal. The company said it would apply for approval to market the drug for weight management later this year and for type 2 diabetes next year. Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow, said: “These are important results. Having new oral agents that lower glucose but also meaningfully lower weight well beyond levels seen with most existing diabetes therapies is critical to future type 2 diabetes care. Of course, one caveat is that we do not know the effects of this newer therapy on cardiovascular outcomes but this will be forthcoming in future trials.” - The Guardian

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For every 10 people who try to get lean, only 1 of them will get lean and manage to keep their lean physique for good. Why? Because most people rely on quick fixes that eventually fall apart, instead of building daily habits that make fat loss stick. I’ve narrowed the answer to how to get shredded down to just 5 simple daily habits. By mastering these habits myself, I recently got down to 11% body fat, and getting lean felt almost automatic. In this video, I’ll show you how to do the same. No gimmicks, no fluff. Just real, research-backed methods to help you get a lean body and stay lean. Click below to try the BWS+ app for free for 2 weeks, no strings attached: https://builtwithscience.com/ Click below to subscribe for more videos: https://www.youtube.com/jeremyethier/?sub_confirmation=1 Follow the fat loss experts I interviewed: Dr. Mike - @RenaissancePeriodization Alberto Nunez - @Team3DMJ Dr. Eric Trexler - @MASSResearchReview How to get shredded habit 1: increase your energy flux. Turns out, the leanest people in the world often eat more calories while maintaining less body fat. Why? Those with a lean body are being more active, being less sedentary. And because of that, they're able to match their energy balance effectively even though they're on a higher calorie diet. But a “highly active” lifestyle doesn’t mean you’re doing a crazy amount of cardio every day. All the experts I spoke to emphasized the power of plain old walking and just getting enough daily steps in. So here’s what I do. I already lift weights 4-5 times a week. But I also make sure I’m taking at least 8,000 to 10,000 steps a day. The second habit you need to get lean: self-monitoring. But with so many things you could track, how do you know what’s actually worth paying attention to? Rank 1 by a long shot is body weight. The second most important thing is macros because your macros, protein, carbs, fats, and then obviously calories derived from that are the real big working gears of your diet, and they're going to have a huge effect on your results. And then rank 3 is steps. Outside of doing them for a good health effect, they’ll also potentiate your fat burning a little bit. Another thing to look for is the way your clothing fits. But to avoid overwhelming yourself, start simple. Begin with just 1 habit: tracking your body weight. Once you’ve got that down, move on to tracking your nutrition. But as powerful as those first 2 habits of getting lean are, you won’t see the results you’re after if you neglect sleep. Sleep is such a critical component of keeping muscle on your body and getting the fat off that it is what I call an absolute non-negotiable. But it’s not just about sleep quantity. Despite equivalent hours of sleep per night, Dr. Eric Trexler found that the leaner folks reported that they were less frequently feeling tired, sluggish, and sleepy throughout the day. So, you need to improve both the quantity and quality of your sleep. If you're serious about achieving a lean physique, here’s what I’d recommend you do. First, try to stick to a consistent sleep schedule. Next, watch your caffeine intake, especially in the afternoon and evening. Next, figure out how much sleep you need by spending 1-2 months being consistent with your bedtime and letting yourself wake up naturally without an alarm. That’ll help you find your ideal sleep duration. And lastly, if your lifestyle makes it hard to get enough sleep at night, naps can be a game-changer. But even with enough sleep, it’ll feel nearly impossible to get lean if you’re not eating the right foods. Start with a high-quality protein source. Think eggs, fish, yogurt, or chicken, roughly the size of your palm. Next, add 1-2 servings of fruits or veggies to most of your meals. These fiber, nutrient-rich foods will prevent you from getting hungry shortly after eating. Lastly, complete your plate with whole grains. Examples include potatoes, brown rice, oats, and/or healthy fats like avocado or nuts. Exactly what and how much you add here will vary depending on your calorie target for the day. The final habit you need to achieve a lean physique: set goals with a hierarchy. The first layer starts with your why. This is your big-picture goal. Layer 2 is your what. Think of these like the categories that make up your transformation. For example, eating healthier and sleeping better. These goals give you direction but still leave room for flexibility. Layer 3 is the how. This is where you apply the habits we went through earlier to lay out your daily routine to achieve your big-picture goal. This shifts your focus away from the outcome, like “losing 20 lbs of fat”, to the daily process that will inevitably get you that result.  Timestamps: 0:00 - Why Habits Are Key to Get Lean 0:38 - Habit 1: Increasing Energy Flux 5:40 - Habit 2: Self-Monitoring 9:00 - Habit 3: Sleep Quality & Quantity 12:47 - Habit 4: Build High Quality Meals 16:44 - Habit 5: Create a Goal Hierarchy

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