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(10 Jan 2006) 1. Wide of exteriors of surgery ward at Polyclinic Hospital Umberto I 2. Exterior of balloon procedure room 3. Room with nurses preparing for balloon inserting procedure 4. Balloon procedure kit 5. Pan down from inflated balloon to a flat one 6. Close up of medical information card 7. Inflated balloon 8. Wide of a surgery room 9. Chief surgeon Nicola Basso preparing for surgery 10. Close up of medical machine 11. SOUNDBITE (Italian) Nicola Basso, Chief surgeon at Polyclinic Hospital Umberto I and Director of balloon procedures: ''It's an endoscopic procedure, which means it doesn't need a general anaesthesia. with an instrument that's usually used to practice endoscopy, a 1/2 litre volume balloon is inserted and is inflated inside the stomach. It occupies a part of the stomach and it slows down stomach emptying. All this produces a lack of appetite, a satiated feeling, all of which makes easier for the patient to lose weight.'' 12. Balloon procedure kit 13. Procedure room with doctors and a patient ready to be operated 14. SOUNDBITE (Italian) Vittorio Campati, Patient ''I'm 140 kilos. With the intragastric balloon I hope to lose weight.'' 15. Doctor preparing drip bottle 16. Sedated patient on operation table 17. Flat balloon is inserted through the patient's mouth 18. Images of the patient's stomach on screen as doctors carry out procedure 19. Doctor's hands inflating balloon, which is inside stomach 20. Endoscopy camera shot of stomach 21. Endoscopy camera inserted through the patient's mouth 22. Various of doctors looking to the endoscopy images of balloon inflating 23. Patient awaking after 10 minute operation 24. Simona Spalliera, patient, walking down hall to show her weight loss 25. SOUNDBITE (Italian) Simona Spalliera, 33 years old patient: ''I've kept the balloon for six months - six months and a half. I weighed 100 hundred kilos. Naturally I stopped measuring my weight because I was so demoralised that I didn't want to know it anymore. I have now lost around 30 kilos.'' 26. Wide of exteriors of Polyclinic Hospital Umberto I SUGGESTED LEAD-IN: After holidays full of too much food and plenty of drink - many people include "losing weight" in the list of new year's resolutions. In Italy, a new medical procedure is making this goal much easier for some to obtain. A balloon is inserted into the stomach and inflated so that patients feel full and eat less. VOICE-OVER: The New Year often brings an appetite for the latest diet fads and exercise regimes in the hopes of shedding a few extra pounds. In Italy, achieving that weight loss could be a bit easier with new "anti-obesity" balloons. These balloons are inserted in the stomach in a simple procedure to give the feeling of being full. And if you feel full, you're likely to eat less which will lead to weight loss. Italian surgeon, Nicola Basso, has been testing the procedure in Rome at the Polyclinic Hospital Umberto I since 1998. He says the procedure is only minimally invasive. SOUNDBITE (Italian) ''It's an endoscopic procedure, which means it doesn't need a general anaesthesia. With an instrument that's usually used to practice endoscopy, a 1/2 litre volume balloon is inserted and is inflated inside the stomach. It occupies a part of the stomach and it slows down stomach emptying. All this produces a lack of appetite, a satiated feeling, all of which makes easier for the patient to lose weight.'' SUPER CAPTION: Nicola Basso, chief surgeon at Polyclinic Hospital Umberto I The balloon contains blue coloured liquid, in order to detect possible leaks. Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives ​​ Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/4fa92418b57e86a220a99fcb19b90de1

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Semaglutide is a medication that has recently gained attention for its potential to aid in weight loss. Originally developed for the treatment of type 2 diabetes, semaglutide has been found to have the side effect of reducing appetite and promoting weight loss in some individuals. This has sparked interest in using semaglutide as a weight loss aid for people who are struggling to lose weight through diet and exercise alone.

How Semaglutide Works for Weight Loss: Mechanism Explained

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. GLP-1 is a hormone that is released by the gut in response to food intake. It plays a key role in regulating blood sugar levels by stimulating insulin secretion and inhibiting glucagon release. In addition to its effects on blood sugar control, GLP-1 has been found to have other metabolic effects, including reducing appetite and promoting weight loss.

When semaglutide is injected, it mimics the action of GLP-1 in the body by binding to and activating the GLP-1 receptors. This leads to increased insulin secretion, decreased glucagon release, slowed gastric emptying, and increased feelings of fullness. These effects combined result in lower blood sugar levels, reduced appetite, and ultimately, weight loss.

One of the key ways that semaglutide promotes weight loss is by reducing appetite. By activating the GLP-1 receptors in the brain, semaglutide signals to the body that it is full and satisfied, leading to a decrease in food intake. This can help individuals consume fewer calories and achieve a calorie deficit, which is necessary for weight loss.

Benefits of Semaglutide for Weight Loss

Studies have shown that semaglutide can lead to significant weight loss in individuals who are overweight or obese. In one clinical trial, participants who took semaglutide lost an average of 15-20% of their body weight over a period of 16-68 weeks. This weight loss was sustained over time and was greater than what was seen in participants who took a placebo.

In addition to weight loss, semaglutide has been found to have other health benefits. It can improve blood sugar control in individuals with type 2 diabetes, reduce risk factors for heart disease, and improve overall metabolic health. These benefits make semaglutide a valuable option for individuals who are struggling to lose weight and improve their health.

Overall, semaglutide is a promising option for individuals who are looking to lose weight and improve their health. By mimicking the action of GLP-1 in the body, semaglutide can help reduce appetite, promote weight loss, and improve metabolic health. As with any medication, it is important to discuss the risks and benefits of semaglutide with a healthcare provider before starting treatment.

Frequently Asked Questions About Semaglutide for Weight Loss

Q: Who is a good candidate for semaglutide for weight loss?

A: Semaglutide is typically recommended for individuals who have a body mass index (BMI) of 27 kg/m² or higher and have obesity-related health conditions, such as type 2 diabetes or high blood pressure.

Q: How is semaglutide administered?

A: Semaglutide is injected subcutaneously once weekly. The dose may be adjusted by a healthcare provider based on individual response and tolerability.

Q: What are the potential side effects of semaglutide?

A: Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically improve over time as the body adjusts to the medication.

Q: How long does it take to see results with semaglutide?

A: Weight loss with semaglutide typically occurs gradually over time. Some individuals may start to see results within a few weeks of starting treatment, while others may take longer to experience significant weight loss.

Q: Is semaglutide a long-term weight loss solution?

A: Semaglutide is intended for long-term use as a weight loss aid. It is important to continue taking semaglutide as prescribed to maintain weight loss and achieve the full benefits of the medication.

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