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Recommendations and clinical experience regarding the use of GLP-1 agonist therapy as treatment in patients with type 2 diabetes and cardiovascular disease.

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Semaglutide (Ozempic) is a GLP-1 receptor agonist that has been shown to be effective in reducing HbA1c levels (a measure of blood sugar control) and promoting weight loss in people with type 2 diabetes. It's a once-weekly subcutaneous injection, and it is approved for use in many countries. Liraglutide (Saxenda) is also a GLP-1 receptor agonist that has been shown to be effective in promoting weight loss in people with obesity. It's available as a once-daily subcutaneous injection. Both medications have shown to be effective in reducing HbA1c levels, promoting weight loss and helping patients to achieve their glycemic targets. However, as with any medication, the best choice of treatment will depend on the individual's medical history and response to treatment, it's best to consult with a healthcare professional for personalized advice. #shots

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Weight loss drugs have become an increasingly popular, but controversial, way of quickly shedding extra pounds over the past few years. Part of that controversy deals with the side effects caused by some of the more well-known medications like Ozempic and Mounjaro. According to the Obesity Medicine Association (OMA), researchers are continually analyzing the pros and cons of these drugs. Here are some side effects of the eight FDA-approved weight loss drugs: Ozempic and Wegovy Ozempic and Wegovy are the brand names of a drug known as semaglutide, a medication that, according to Harvard Health, has been prescribed for about two decades to treat Type 2 diabetes. Ozempic has become controversial over the past few years as overweight and obese patients have sought it out for weight loss, creating a shortage of the drug for those using it to control their diabetes. Wegovy is the brand name for a form of semaglutide that has since been approved for weight loss. Semaglutide, which mimics a natural hormone called GLP-1, helps regulate blood sugar while slowing down the emptying of the stomach and signaling satiety or fullness to the brain. The OMA reports that the most common complaint among patients using semaglutide is gastrointestinal issues like nausea. Other side effects include fatigue, dizziness, headache, bloating, belching and heartburn.An American Medical Association study has also found that GLP-1 agonists are associated with an increased risk of pancreatitis, bowel obstruction, and gastroparesis. While headlines have warned about an increase in suicidal ideation with semaglutide, a January 2024 study in Nature Medicine suggested “a 49% to 73% lower risk of first-time or recurring suicidal ideations” compared with other obesity medications. Mounjaro and Zepbound Mounjaro and Zepbound are drugs known as tirzepatide. Mounjaro was approved in 2017 to treat Type 2 diabetes, while Zepbound was approved in more recent years to treat obesity. Like semaglutide, tirzepatide is a GLP-1 agonist that increases a person’s feeling of fullness and helps them maintain a weight loss diet. It causes common mild symptoms like nausea, constipation, diarrhea and bloating, but the OMA reports more serious side effects like kidney problems up to and including kidney failure, gallbladder symptoms, pancreatitis and hypoglycemia. Manufacturer Eli Lilly warns, however, that Tirzepatide may cause thyroid tumors or thyroid cancer. Patients should monitor themselves for symptoms like neck swelling, hoarseness, problems swallowing and shortness of breath. Contrave Contrave is the brand name for a medication that combines two drugs, bupropion and naltrexone. Bupropion, which is marketed under the brand name Wellbutrin, is an antidepressant that is also known to reduce a person’s appetite. Naltrexone, commonly sold under the brand names Revia and Vivitrol, is a medication used to treat drug and alcohol addiction. According to Drugs.com, naltrexone works by blocking the euphoric, intoxicated feeling of alcohol and opioids. It also helps reduce the cravings for the substances. The OMA reports that patients should not be prescribed Contrave if they suffer from a seizure disorder or if they take opioids for chronic pain. The most common side effects of the drug are nausea, vomiting, constipation, diarrhea, headache, dizziness, dry mouth and insomnia. Saxenda Saxenda is a medication containing liraglutide, a drug that mimics a person’s natural hormones affecting hunger, digestion and feelings of fullness. It was approved by the FDA in 2017 to treat obesity in people 12 and older. The most common side effects of liraglutide are nausea, vomiting, constipation, diarrhea, headache, fatigue, dyspepsia, dizziness and abdominal pain. It can also cause increased heart rate, increased lipase, which is a pancreatic enzyme, and decreased kidney function. Qsymia Qsymia is a medication that combines the drugs phentermine and topiramate. According to the OMA, phentermine has been around since 1959, making it the oldest and most widely used weight loss medication. The drug, which works in the brain as an appetite suppressant, is a stimulant similar to amphetamines and can be abused. It should not be used by patients who have suffered a stroke or who have heart disease, glaucoma or hyperthyroidism. The side effects of phentermine can be serious, including fast or irregular heart rate, headache, overstimulation, high blood pressure and tremors. It can also interact with several other drugs, including MAO inhibitors, alcohol, adrenergic neuron blockers and some anesthetic agents. When phentermine is combined with topiramate, an anticonvulsant, its effect on hunger is magnified. The side effects of the two drugs combined include dizziness, abnormal sensations, altered taste, insomnia, constipation and dry mouth. Topiramate also carries a risk of birth defects, so it should not be taken during pregnancy.

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Semaglutide is a medication that has been making headlines in recent years due to its potential for weight loss. Originally developed as a treatment for type 2 diabetes, semaglutide has shown promising results in helping people shed pounds and improve their overall health. But what exactly is semaglutide, and how does it work for weight loss? In this article, we will explore the ins and outs of this medication, its benefits, potential side effects, and more.

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What Is Semaglutide?

Semaglutide is a type of medication known as a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by mimicking the effects of a hormone in the body called GLP-1, which helps regulate blood sugar levels and appetite. When semaglutide is taken, it can help control blood sugar levels, reduce hunger, and increase feelings of fullness, all of which can contribute to weight loss.

Semaglutide is typically administered via a once-weekly injection, making it a convenient option for those looking to manage their weight. It is important to note that semaglutide is not a magic pill for weight loss and should be used in conjunction with a healthy diet and exercise regimen for best results.

While semaglutide was initially developed for the treatment of type 2 diabetes, it has also been found to be effective in promoting weight loss. In fact, some studies have shown that semaglutide can lead to a significant reduction in body weight, making it a potentially valuable tool in the fight against obesity.

How Does Semaglutide Work for Weight Loss?

The exact mechanism of how semaglutide promotes weight loss is not fully understood, but it is believed to involve several factors. One key way that semaglutide helps with weight loss is by slowing down the emptying of the stomach, which can lead to increased feelings of fullness and reduced food intake.





In addition to reducing appetite, semaglutide may also help increase the body’s sensitivity to insulin, the hormone responsible for regulating blood sugar levels. By improving insulin sensitivity, semaglutide can help the body better utilize glucose for energy, rather than storing it as fat.

Furthermore, semaglutide has been shown to have a positive impact on certain brain regions that control food intake and energy balance. By affecting these areas, semaglutide may help regulate food cravings and prevent overeating, leading to weight loss over time.

Potential Side Effects of Semaglutide

Like any medication, semaglutide may cause side effects in some individuals. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.

In some cases, semaglutide may also cause more serious side effects, such as pancreatitis or kidney problems. It is important to speak with your healthcare provider before starting semaglutide to discuss any potential risks and benefits of the medication.

Overall, the benefits of semaglutide for weight loss may outweigh the risks for many people, especially those who are struggling to lose weight through diet and exercise alone. By working with your healthcare provider to monitor for any potential side effects, you can safely incorporate semaglutide into your weight loss plan.