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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?
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Dr. Oz has for a long time been an important person in the health and wellness industry, and his television show where he educates people as well as books that have sold a lot make him so. Recently, however, he appeared on Shark Tank as a guest judge where new companies pitch their ideas to successful business people. Since he became part of the judges’ panel on Shark Tank, Dr. Oz has developed specific interest in innovations associated with keto dieting, which is a low-carb high-fat eating plan that has gained popularity for its several health benefits.
Dr. Oz’s Interest in Keto
The ketogenic diet has found an advocate in Dr. Oz who believes it helps with weight loss, energy level improvement and may even lower chances of suffering from some chronic conditions. Being featured by Dr. Oz on his show many times; hosting experts to talk about it and giving success stories from people who have tried it out themselves shows how much Dr.Oz’s interest in keto has grown since joining shark tank which is always looking out for newer and better ways to support this way of eating.
A key benefit of ketogenic eating is that it forces the body to use up fat instead of carbohydrates as its source of energy leading to weight loss and boost on energy among other possible advantages towards good health. For example, during his participation at Shark Tank, Dr. Oz acknowledged entrepreneurs who had created products meant assist individuals embrace keto such as meal kits for keto diets, low carbohydrate snack items or even supplements.
Keto Products on Shark Tank
During his stint on Shark Tank program however there were many products about Keto presented for investment by entrepreneurs before the investors including desserts friendly with ketosis; meal replacements like shakes; cooking devices designed specifically for preparation of low carb meals among others just to mention but a few. What interested Dr.Oz were not only tasty snacks but also holistic wellbeing attributes in the product they are promoting into the market because while both these attributes are of equal importance when creating new products, there is always a high degree of propensity for sacrifice of one over the other.
In some instances, more than one investor have shown interest in certain keto products on Shark Tank resulting into bidding wars on the show. He was amazed by entrepreneurs who came up with such items and went to great lengths to help people live healthily. To him, the increasing popularity of ketogenic diets demonstrates a move towards personalized nutrition and wellness.
Future of Keto Innovation
As the popularity of ketogenic diets continues to rise, Dr. Oz predicts that even more innovations will emerge from the keto space. Entering this market place is seen as an opportunity to produce healthy tasting food items rather than foods that are just ‘good for you’ according to Dr.Oz. Entrepreneurs do not need to insist on particular kinds of food; they can choose any product as long as it complies with requirements like low carb snack options, meal replacements or cooking gadgets which make life easier for many people who complain about preparing their meals while observing diet rules like ketosis.
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Do you still want to get into ketosis for the benefits of a low-carb, high-fat diet, but hate following strict meal plans? Then Keto Blast Gummies is for you. But is it Keto Gummies are affordable and great for assisting your journey toward ketosis if you desire to reap the benefits of the keto lifestyle. They are perfectly convenient and fun gummies for helping you manage this diet. In this Keto Blast Gummies review, we are going to examine their affordability along with how it gives you the opportunity to make the world of the ketogenic diet available to you.
Convenient Ketosis in a Gummy Form
Keto Blast Gummies are a convenient, easy and tasty way to support your keto diet. Made with exogenous ketones, these gummies can help your body enter ketosis at a quicker speed and greater rates. Try and eat Keto Blast Gummies to induce your body to use fat for energy instead of carbohydrates. As a result, this can increase your energy levels and lead to better weight loss results.
On top of that Keto Blast Gummies is easy to carry around with you anywhere you go which means you can remain in ketosis no matter where you find yourself, be it at work, at the gym or even on your travels..
Keto Blast Gummies gives you the keto lifestyle on a stick, allowing you to avoid complicated meal prep and carb-counting: simply pop a few in your mouth each day to help put and keep the body into the state of ketosis and reap the benefit of the ketogenic diet.
Affordable Access to Ketogenic Success
An important attraction to Keto Blast Gummies would be its price. Since supplements used to burn fats can cost heavily at times, Keto Blast Gummies are reasonably priced, which anyone can afford to use. With consistent usage of these gummies, you can help your body to get into ketosis and a faster rate without worrying about shelling a lot of bucks.
With this investment, you are investing in yourself, your well-being, and your ability to succeed in your keto diet. By helping your body stay in ketosis, Keto Blast Gummies help you achieve your weight loss and workout goals. Keto Blast Gummies offer a fantastic price point, making it easier than ever to invest in your body without breaking the bank.
Keto Blast Gummies make sure that the cost of other keto supplements can not stop you from enjoying all the benefits of a keto diet. If you also want to access all its benefits without caring for extra charges, you should switch to Keto Blast Gummies. This supplement will allow you to enjoy all the benefits of keto without spending a fortune.
FAQ
What are the key ingredients in Keto Blast Gummies?
This is where keto Blast Gummies come in, with the addition of exogenous ketones. This means your body will ease into ketosis better and quicker, with the added bonus of enjoying the multivitamins on top of their ketone-infused formulation. Chew’s powders and gummies are made from all-natural sources and contain no sugars or psyllium fibres, making them safe to have daily.
How many gummies should I take each day?
To get maximum benefits from this supplement, you must take right amount of Keto Blast Gummies, which is two gummies per day. It is recommended to take one gummy in the morning time and second one should be in the evening before you go to bed.
Can I take Keto Blast Gummies if I have dietary restrictions?
Overall, I believe ketogummies keto blast e liquid gummies is an excellent choice as a supplement for most people on the ketogenic diet, but you should still check with your physician to ensure they are a good fit for you, particularly if you have any dietary restrictions or food allergies.
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Amazing Testimonials About Weight Loss With A Natural Glp1 Activator
Discover effective natural alternatives to GLP-1 agonists for weight loss in this insightful video! Join Fernando as he explores evidence-based options that are powerful compounds that can help control appetite, stabilize blood sugar, and promote weight loss without prescriptions. Learn how these natural alternatives work, their benefits, and the best ways to incorporate them into your daily routine. Plus, don't miss Fernando's personal favorite combo for achieving GLP-1-like results naturally! If you find this content helpful, please like and share the video. Let's empower each other on our health journeys! #WeightLoss #NaturalHealth #GLP1Alternatives #WellnessJourney #healthylivingusa 00:00:00 Introduction to Natural GLP-1 Alternatives 00:00:14 Understanding GLP-1 Agonists 00:00:30 Exploring Natural Alternatives 00:00:51 The Science Behind GLP-1 and Natural Compounds 00:01:06 Synthetic vs. Natural GLP-1 00:01:25 Alternative #1 00:02:14 Alternative #2 00:03:06 Alternative #3 00:04:03 Honorable Mentions - Synergistic Support 00:04:08 List of Natural Options 00:04:44 Sample Supplement Regimen 00:04:51 Sample Supplement Stack 00:05:19 Medical Disclaimer 00:05:53 Final Words
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