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In erectile dysfunction, an individual is unable to develop or maintain an erection during sex. This disorder is also called impotence and like other sexual dysfunction, this condition becomes more common with age. Sex can be important within relationships, so erectile dysfunction often carries with it emotional and psychological stigma. In both males and females,, sexual activity involves a sequence of events called the sexual response cycle. This cycle has four phases, excitement, plateau, orgasm, and resolution. During the excitement phase, muscle tension, heart rate, and blood flow to the genitals increases. In males, this is called an erection. When these reach the maximum level, it’s called the plateau phase. Next, the accumulated sexual tension gets released during orgasm, causing ejaculation in males. Immediately after orgasm comes the resolution phase, where the body slowly returns to its original, un-excited state. Alright, let’s take a closer look at the penis which is made of three long cylindrical bodies: the corpus spongiosum that surrounds the penile urethra, and the two corpora cavernosa made of erectile tissue. The corpora cavernosa are wrapped in a fibrous coat called the tunica albuginea, and each corpus cavernosum is made up of blood-filled spaces called the cavernosal spaces. These areas are lined with endothelial cells surrounded by smooth muscle. Running down the centre of each corpus cavernosum is a large artery called the deep artery which gives off smaller arteries that supply the cavernosal spaces. Next, blood get drained from these spaces by small emissary veins, which drain into the deep dorsal vein. This vein then carries the blood back into the systemic circulation. Now, the penis receives both somatic and autonomic innervation through the cavernous nerves, which innervate both the corpus spongiosum, and the corpora cavernosa. Hypertension causes wear and tear in the endothelial cells, and decreases their ability to produce nitric oxide. Another vascular condition that can damage the arteries is diabetes mellitus. High glucose levels can cause hyaline arteriolosclerosis in the small arterioles in the penis. This is where the arteriole walls develop hyaline deposits, which makes it harder for them to dilate. It also builds up in the capillaries causing the basement membrane to thicken which makes it harder for oxygen to efficiently move from the vascular space to the tissues, causing hypoxia and death of the smooth muscle cells. Hypoxia also causes the parasympathetic nerve fibers to die off, and damaged parasympathetic nerve fibers can’t release acetylcholine, so there’s less nitric oxide synthase activation, and less nitric oxide is produced. Another leading cause of erectile dysfunction is surgery, either on central nervous system structures, like the brain and spinal cord, or on the genital structures themselves, like prostate surgery. Also, conditions like stroke, multiple sclerosis, and back or pelvic trauma can directly damage the nerves, leading to erectile dysfunction. Next, endocrine dysfunctions that causes testosterone levels to fall, like hypogonadism, can cause erectile dysfunction. This happens because low testosterone levels are associated with lower levels of nitric oxide synthase, which causes less nitric oxide to be produced, and less smooth muscle relaxation. Since testosterone production decreases with age, it’s normal for erections to become more difficult to achieve and maintain later in life. Finally, many medications can cause erectile dysfunction as a side effect. These include diuretics because they leave less fluid in your circulation, making it difficult to achieve an erection, and medications like antidepressants and methadone, but those mechanisms are not as well understood. There is no specific test to diagnose erectile dysfunction, so the diagnosis largely relies on the sexual experiences of the individual. Careful questioning of psychological stressors as well as blood tests to check for testosterone and glucose levels, a neurological assessment, and duplex ultrasound to evaluate blood flow and atherosclerosis can be done to investigate the cause of erectile dysfunction. Treatment of erectile dysfunction largely focuses on addressing the underlying cause. In terms of medications, PDE-5 inhibitors, like sildenafil can be used. These medications inhibit the PDE-5 enzyme in endothelial cells which normally breaks down cGMP, leading to higher levels of cGMP. That allows for more smooth muscle relaxation which facilitates an erection. Sometimes, vacuum erection devices can be used. These devices apply negative pressure around the penis which can help draw in blood to achieve an erection. Finally, surgical procedures like prosthetic implants can be embedded into the penis. They does not cause erections but it could help keep the penis rigid.

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Phonics is the best way to learn the 26 letters of the alphabets. Slow and steady is the way to teach toddlers anything new. This preschool video on the Phonics letter A will teach you babies all the objects that begin with the letter A. Learning the ABC's just got a lot more fun and interesting, didn't it? Watch the preschool video as many times as you like, because practice makes one perfect. So learn the ABC's one letter at a time with our kindergarten friends. ============================================ Music and Lyrics: Copyright USP Studios™ Video: Copyright USP Studios™ ============================================

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Magnesium in quinoa plays a vital role in improving blood circulation, which is key to a healthy sexual life. Learn how quinoa can support your sexual wellness and overall health. Watch the full video for more insights and share your experiences in the comments!

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Subscribe for Weekly New Highlights! 👇🏻 https://cutt.ly/Fh7iXJE A Highlight from Episode: #59 Date of Release: December 14th I post New Highlights of the UNFILTERED: Zane & Heath Podcast EVERY Week! Subscribe for weekly best moments of the podcast! If you guys are confused whether the highlight is new or old, always check the title of my videos. Videos that have “New Unfiltered Podcast” in the title, are posted up to 1-5 days after the release of an episode. Old clips are labeled as “Throwback Clip” in the description. I also post the name of the Episode & Date as you can see above 👆🏻. I hope that clears any misconceptions ;) I post New Clips EVERY Wednesday, Thursday, Friday, Saturday & Throwback Clips EVERY Sunday, Monday and Tuesday! Subscribe, Like & Comment! Heath Hussar Zane Hijazi David Dobrik Mariah Amato Unfiltered podcast Vlog Squad #unfiltered#podcast

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Why are leaders corrupt? This question has teased and taunted researchers over the years; however, there is not much research that has examined this question using experimental designs that give real power to leaders in real-stakes situations. In this animated, fun, but also science-packed podcast, Prof. John Antonakis explains what he and his colleagues--Dr. Samuel Bendahan, Prof. Christian Zehnder, and Prof. François Pralong--found in two experimental studies. Both power (leader choice set and number of followers) and the person (baseline testosterone) caused corruption. The implications of this study are far reaching and should make individuals responsible for organizational governance mechanisms to pause and think about how much power and discretionary choices leaders should have. Link to read the article: http://dx.doi.org/10.1016/j.leaqua.2014.07.010

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How Daily Cialis Can Prevent Erectile Dysfunction Ever thought a simple daily routine could revolutionize your sexual health? We're breaking down how Daily Cialis could be the powerhouse solution you never knew you needed! ------------------------------------------------------ Justin Houman, MD is a urologist and Men's Health Specialist on YouTube to educate people about all things Urology and Men's Health including erectile dysfunction, how to increase testosterone, problems with sex, male fertility, vasectomies, vasectomy reversal, and Peyronie's Disease. ------------------------------------------------------ Subscribe: https://www.youtube.com/c/jhouman?sub_confirmation=1 Share this video with a friend: https://youtu.be/dgooJlhrOig ------------------------------------------------------ Learn more at: https://houmanmd.com/ or Request a consultation: 310-854-9898 https://houmanmd.com/contact/ ------------------------------------------------------ Check out these Playlists: Erectile Dysfunction: https://www.youtube.com/playlist?list=PLtY1uZYX3H4_JthkK00rt8Aqcln9o6peP How to Optimize Testosterone Levels: https://www.youtube.com/playlist?list=PLtY1uZYX3H49EvhwJl99hkHTQVKBgZBIe Male Infertility: https://www.youtube.com/playlist?list=PLtY1uZYX3H48I5urkPBi5osUXmNIJcnUU Vasectomy Reversal: https://www.youtube.com/playlist?list=PLtY1uZYX3H49EwPcMoF6BC8CyW2cTaN_Z Vasectomy: https://www.youtube.com/playlist?list=PLtY1uZYX3H49Gm8NQz___i6AQtDfdPPcU Peyronie’s Disease: https://www.youtube.com/playlist?list=PLtY1uZYX3H49QaiSgzBmUNnuCECTZmLa- ------------------------------------------------------ AMAZON STOREFRONT: https://www.amazon.com/shop/justin.houman.md ----------------------------------------------------- Let's Connect!: WEBSITE: https://houmanmd.com/ LINKTREE: https://linktr.ee/justinhoumanmd INSTAGRAM: @Justin.Houman.MD https://www.instagram.com/justin.houman.md/ TWITTER: @JustinHoumanMD https://twitter.com/JustinHoumanMD/ TIKTOK: https://www.tiktok.com/@justin.houman.md FACEBOOK: @LAMensHealth https://www.facebook.com/LAMensHealth/ LINKEDIN: https://www.linkedin.com/in/justin-j-houman-md-aa697123/ ----------------------------------------------------- DISCLAIMER: This video is purely educational and does not constitute medical advice. The content of this video is my personal opinion and not that of my employer(s). Use of this information is at your own risk. Justin Houman, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of the information contained in this video including but not limited to economic loss, injury, illness, or death. #menshealth #cialis #testosterone #infertility #vasectomy #vasectomyreversal #malefertility #maleinfertility #peyronies #lowtestosterone #erectiledysfunction