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Hey everyone, Connor with Honor here! In this portion of the video, I dive into losing body weight with FDA-approved meds—specifically GLP-1 agonists like Ozempic, Wegovy, and more. As someone who once weighed 365 lbs with a 65-inch waist, I understand the daily battles with diet, cravings, and health issues. Over the course of 7.5 months, I managed to drop 135 lbs of fat through a combination of fasting, hormone therapy, and a whole lot of discipline. But even with that success, I’m always looking for new insights on weight loss—especially the pros, cons, and potential pitfalls of modern medications. In this segment (roughly 00:04:24 – 00:11:23), I discuss how drugs like Ozempic and Wegovy can suppress appetite, helping you reduce your overall caloric intake in a way that mimics some benefits of fasting. However, there’s a major caveat: muscle loss. If you’re not pairing these meds with resistance training, you risk losing lean body mass that’s already tough to build (or rebuild). And that’s why I’m sounding the alarm—because losing fat is great, but losing muscle can ultimately hurt your metabolism, bone density, and overall strength. Below, you’ll find more highlights from this section of the video, along with direct links to my full YouTube upload and an in-depth blog post detailing everything I’ve learned on this topic. Read on for the breakdown: 1. My Personal Journey (00:04:24 – 00:05:40) I spent much of my life overweight—even while I was serving as a police officer for the LAPD. After countless yo-yo diets, I discovered fasting (ranging from a day to 14 days straight) and hormone therapy to address low testosterone levels. This combination helped me go from 365 lbs to around 230 lbs in about 7.5 months, torching 135 lbs of fat. Why This Matters: If you’re considering FDA-approved weight loss meds, ask yourself if it’s riskier to remain obese or to try a doctor-supervised medication. It’s not a simple yes/no question—your personal health context matters, and you’ll want professional guidance either way. 2. GLP-1 Agonists: Appetite Suppression & Cautions (00:05:41 – 00:09:00) Ozempic, Wegovy, and similar meds are known as GLP-1 receptor agonists, which can drastically reduce your hunger signals. Think of it like a “chemical version” of intermittent fasting. Muscle Loss Concerns: Because these drugs curb your appetite, you might eat too few calories, prompting your body to target lean tissue (i.e., your muscles) for energy. Over time, this can lower your metabolism. What Science Says: Some studies suggest a significant portion of the weight lost on GLP-1 meds can be muscle unless you adopt resistance training to preserve strength. 3. Fasting vs. Meds: Metabolic Myths (00:09:01 – 00:10:10) Fasting can actually increase your metabolism by around 10% (especially in the early stages), contrary to the old “fasting = starving” myth. It’s your body’s evolutionary response to get you energized enough to hunt. With GLP-1 meds, you’re still eating (just far less), so you might not get the same metabolic bump from fasting. Instead, it’s more like a “chronic calorie restriction,” which might lower your metabolic rate if not done correctly. Remember: Metabolism is about more than just calories in vs. calories out. Hormones, muscle mass, and daily activity levels all play vital roles. 4. Doctor Visits & Hard Questions (00:10:11 – 00:11:23) I once asked a skeptical doctor, “What’s riskier for me: remaining at 365 lbs or taking a medically supervised hormone replacement?” The doctor couldn’t give a solid answer. If you’re considering GLP-1s (or any weight-loss med), ask yourself: Is the bigger risk staying at my current weight or trying this prescription? Every choice has trade-offs. Side Effects & Long-Term Unknowns: GLP-1 meds are relatively new in the mainstream market. Keep an eye on side effects and stay in close contact with your healthcare provider. Watch the Full Video YouTube Link (raw): https://youtu.be/2TEsk6oNrdE?si=n9cyr9r_RCAqS9J2 Time Range: This weight-loss segment starts around 00:04:24 and runs to about 00:11:23. If you want to see my entire discussion—from Santa Clarita real estate updates to AI concerns and a pep talk for young men stuck in basements—watch the video in full. Everything’s timestamped, so you can jump right to the parts that interest you. Read the Detailed Blog Post If you’re craving more context—like how these topics tie into real estate, tech shifts, or general self-improvement—check out my blog post for a comprehensive rundown of all four segments covered in this video: Blog Link (raw): https://www.santaclaritaopenhouses.com/2025-santa-clarita-update-glp-1-agonists-fat-ai-dangers-boys-to-men —Connor with Honor Former LAPD, current Santa Clarita Realtor, and an ever-learning human on a mission to help others live healthier, smarter, and more fulfilling lives.

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In this episode, Dr. Tyna dives deep into a 2022 review by Marut et al. published in the Journal of Orthopaedic Translation, exploring the potential of GLP-1 and GLP-2 agonists in treating osteoarthritis. With her extensive background in musculoskeletal medicine, Dr. Tyna connects the dots between metabolic dysfunction, inflammation, and degenerative joint disease, offering a fresh perspective on how these peptides could revolutionize care for millions. 🚨 What You’ll Learn: 1️⃣ The link between osteoarthritis and metabolic dysfunction (“diabetes of the joint”) 2️⃣ How GLP-1 agonists offer anti-inflammatory, immunomodulatory, and neuronal protection benefits 3️⃣ Why standard treatments for osteoarthritis fall short—and how peptides could fill the gap 4️⃣ The intricate relationship between joints, muscles, bones, and inflammation 5️⃣ Why early intervention and a comprehensive approach are crucial for managing osteoarthritis 💡 Key Takeaway: Osteoarthritis isn’t just a mechanical issue—it’s a metabolic and inflammatory condition. GLP-1 agonists show immense promise in addressing these root causes, potentially transforming treatment strategies for millions of people worldwide. 👉 If you or someone you know is dealing with joint pain, this episode is a must-watch. Watch the full version- https://www.youtube.com/watch?v=B_XzVDsksJE&t=67s _____________________________________________________________________________________________ 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦 - https://www.instagram.com/drtyna/ 𝐖𝐞𝐛𝐬𝐢𝐭𝐞 - https://www.drtyna.com/ 𝐒𝐭𝐨𝐫𝐞 - https://store.drtyna.com/ 𝐂𝐨𝐮𝐫𝐬𝐞𝐬 - https://www.drtyna.com/store 𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐑𝐞𝐯𝐚𝐦𝐩 𝐓𝐨𝐨𝐥𝐤𝐢𝐭 - https://bit.ly/drtynametabolicrevamp 𝐅𝐑𝐄𝐄 𝐆𝐮𝐢𝐝𝐞 - Assess Your Metabolic Health - https://www.drtyna.com/metabolism 𝑶𝒛𝒆𝒎𝒑𝒊𝒄 𝑼𝒏𝒄𝒐𝒗𝒆𝒓𝒆𝒅 𝑭𝑹𝑬𝑬 4 𝑷𝒂𝒓𝒕 𝑽𝒊𝒅𝒆𝒐 𝑺𝒆𝒓𝒊𝒆𝒔 https://www.drtyna.com/ozempicuncovered 𝑺𝒖𝒃𝒔𝒄𝒓𝒊𝒃𝒆 𝒕𝒐 𝑻𝒉𝒆 𝑫𝒓. 𝑻𝒚𝒏𝒂 𝑺𝒉𝒐𝒘: 🍎Apple Podcasts: https://apple.co/4bm3R3m 🎵Spotify: https://spoti.fi/3OtOps7 🎙️Substack: https://drtyna.substack.com/ _____________________________________________________________________________________________ 𝗗𝗜𝗦𝗖𝗟𝗔𝗜𝗠𝗘𝗥: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

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Kevin R. Gendreau, MD, is a board-certified obesity medicine physician, author, and advocate for metabolic health based in Fall River, Massachusetts. With a personal journey of losing 125 pounds and reversing type II diabetes through lifestyle modifications, Dr. Gendreau brings a unique and compassionate perspective to his work. Dr. Gendreau is the author of Metabolic Health Handbook: A Doctor’s Guide to Overcoming the Hormonal and Biological Barriers to Fat Loss, a comprehensive guide to achieving better metabolic health. Find Dr. Kevin Gendreau at- Find Dr. Gendreau at- https://kevingendreau.com/ IG- kevingendreau Find Boundless Body at- myboundlessbody.com

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