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Breaking Developments in GLP-1 Treatments: Legal Battles, New Molecules, and Healthcare Policies In this week's episode of Downsized News, hosts Laraine and Christopher Durham bring the latest updates on GLP-1 treatments and their impact on obesity and diabetes. They discuss a significant legal decision allowing the FDA to limit compounded Tirzepatide, and its implications for personalized medications. Also covered is Novo Nordisk's new direct pharmacy program offering Wegovy at reduced prices and their ongoing addiction studies with GLP-1 drugs. A groundbreaking study from NYU Langone Health reveals that GLP-1 medications can enhance the longevity and reduce organ failure risks in kidney transplant recipients with type 2 diabetes. Minnesota lawmakers consider mandating insurance coverage for weight loss drugs, while North Carolina state health officials push for a $100 million budget to reinstate GLP-1 coverage for state employees. Lastly, Stanford Medicine researchers discover BRP, a new molecule potentially more effective than Ozempic for weight loss, with fewer side effects. This episode is packed with critical insights that could influence the future of GLP-1 therapies. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction and Today's Headlines 00:32 Hosts' Personal Success Stories 01:25 Legal Battle Over Compounded Medications 02:26 Novo Nordisk's $499 Wegovy 02:52 GLP-1 Drugs and Addiction Studies 04:37 Kidney Transplant Study on GLP-1 Medications 08:35 Minnesota's Insurance Coverage Proposal 10:48 North Carolina's Efforts to Restore Coverage 15:02 Stanford's Breakthrough Molecule BRP 19:12 Conclusion and Call to Action

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Dr. Sean Spencer from Stanford's Microbiome Lab: probiotic pills reduce microbiome diversity and survival rates for cancer. Viva Longevity's mission is to find the most credible scientists and help them tell their stories. PAPERS: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT https://www.cell.com/cell/fulltext/S0092-8674(18)31108-5 Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response https://www.science.org/doi/10.1126/science.aaz7015 VIDEO: Feeding Your Microbiome: Dietary Strategies for Wellness and Disease Prevention https://youtu.be/zib0MmDrHPg 0:00 Dr. Sean Spencer MD, PhD 2:11 Probiotic pills are risky 4:39 Probiotic pills and cancer 15:36 Freezing your poop for a rainy day 23:58 Why fermented food is healthy 28:01 Fiber 32:28 Industrialization of the microbiome 39:12 Soluble vs insoluble fiber 48:09 GLP-1, fiber, and weight 59:54 Fecal transplants for IBD 1:02:28 What your poop reveals 1:14:58 Healthy gut for athletics

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The average weight loss is 22% of your body weight over the course of 72 weeks, so a little more than a year. This number is based on the 15 mg dose of tirzepatide (Mounjaro). There are many stories of people, especially on TiKTok, of people losing anywhere from 60 to more than 100 pounds. Charles Barkely for example, lost 60 pounds. It took Tara Rothenhoefer about 2 years to lose 176 pounds. The amount of weight you lose depends on several factors, mainly the dose of tirzepatide (AKA Mounjaro), diet, and amount of exercise.

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When it comes to losing weight there is a perception that any weight loss is good, Dr. Kenneth Mitchell explains the goal should really be losing excess fat.

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