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Over a quarter of the Indian adult population is either obese, at risk of diabetes or are diabetic. This has become a marketing & business opportunity for a lot of fitness & healthtech companies with plain vanilla no science interventions focussed on either high protein, calorie counting, CGM driven or at worst GLP-1 drugs. But these companies fail to understand how human biochemistry works. These interventions, if they help in weight loss, is a stop gap arrangement. Weight gain is not the cause but the effect & symptom. Obesity is triggered by low grade chronic inflammation & our body tries its best to maintain a metabolic homeostasis. However, regular insults we do to our body by consuming toxins or ingesting those foods that are transformed by your microbiome into toxins or pro-inflammatory metabolites makes it hard for us to lose weight. Some of these metabolites include LPS, TMAO, P-cresol & more. While microbes living in our mouth & gut also produce certain beneficial metabolites & incretin hormones ( providing we are feeding them with the right food substrates) that maintain our metabolic health & make it hard for us to gain weight. One of the most important metabolites ( incretin hormone) is GLP-1. Yes, our body automatically produces GLP-1 by synthesising fibre & polyphenols in the food we eat. GLP-1 has multiple benefits via regulating various metabolic pathways-regulates blood sugar response, communicates with brain via gut-brain axis , telling that you are full & even tells stomach & intestine to slow the movement of digestive tract. However, these GLP-1 drugs which lot of companies claim mimics natural GLP-1 brings multiple side effects & just ingesting these drugs does not mean it will help you lose weight. -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs . -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help. -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. We at Genefitletics measures these pathways to construct nutritional therapeutics interventions aligned with your biochemistry that reinstates yout metabolic homeostasis Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC4112002/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://pmc.ncbi.nlm.nih.gov/articles/PMC10391832/ https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC5082693/ #obesity #obesityfreeindia #obesityfreenation #obesityawareness #viralvideo #virlshort #viralreels #viral_video #viralshorts #viralnews #healthnews #healthtips #health #healthylifestyle #supplements #obesitymedicine #obesityprevention #obesityawareness #type2diabetes #diabetesawareness #diabetesmanagement #diabetescare #diabetescure

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#Sehat | 16 July 2025 | Episode No: 1173 In today’s show, we are discussing following topics: 1. Why is skipping meals like breakfast, lunch, or dinner not effective for weight loss? Can skipping meals harm your metabolism and overall health? What are the risks of using meal skipping as a weight loss strategy? Vandana Verma, Principal Dietician, Sir Gangaram Hospital, Delhi explains. 2. Fauja Singh, affectionately known as the “Turbaned Tornado,” tragically passed away at age 114 on July 14, 2025, after being struck by an unidentified vehicle while walking near his home in Beas Pind (Jalandhar), Punjab. He was an avid runner. Dr. Indramani Upadhyay, Head, Physiotherapy, Centre for Knee & Hip Care Clinic, Vaishali explains the health benefits of running. 3. What happens to your body when you eat popular Indian street foods like samosa, pav bhaji, or jalebi? How do these deep-fried and sugar-rich foods affect your digestion, energy levels, and long-term health? Can frequent consumption of such dishes lead to weight gain, inflammation, or other metabolic issues? Diksha Chhabra, Nutritionist & Fitness Expert explains. #Sehat #Health #weightloss 00:00 -Intro 00:44 -घंटों भूखा रहने से वज़न घटेगा नहीं, बढ़ेगा! 05:22 -दौड़ने के ये फ़ायदे आज तक नहीं सुने होंगे! 10:09 -समोसे, छोले भटूरे के शौकीनों, आपके लिए बुरी ख़बर है! 13:41 -Outro The copyright ownership in the video rests with India Today Group. No third party is permitted to use the video without obtaining the permission of India Today Group. Any permission for usage can be obtained through the email ID provided here [email protected]. खबरों को विस्तार से पढ़ने के लिए क्लिक करें यहां- https://www.thelallantop.com/ Instagram: @thelallantop Facebook: @thelallantop Twitter: @TheLallantop Production: Aditi Agnihotri & Sarwat Fatima Video Editor: Alok Sahu

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