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In this episode of "In the Interim..." we revisit the ground-breaking seamless phase 2/3 clinical trial for the GLP-1 agonist, dulaglutide—better known as Trulicity. We discuss the intricacies of the adaptive trial design, and the unique features that helped expedite development by 12-18 months. Listeners will gain insight into how Bayesian algorithms and innovative statistical methods were pivotal in navigating a complex trial design, benefiting Eli Lilly's pipeline and changing the landscape of diabetes treatment. Key Highlights: —Outline of the trial design and the barriers faced during its inception in 2007-2008. —Explanation of the Clinical Utility Index and its role in adaptive randomization. —The DSMB's role and interaction with Bayesian decision-making models. —Simulation-based design to optimize development efficiencies. —Insights into the predictive power of the trial on weight loss outcomes in subsequent trials. Quotes: —"The trial was run entirely by Bayesian algorithms." – Scott Berry —"They believed this utility function was absolutely the right way to go forward." – Scott Berry For more head to berryconsultants.com.

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What is Food Noise? | Why Are People Taking GLP-1 Weight Loss Drugs? | Sanskriti IAS #foodnoise #GLP1Drugs #glp1 #obesitytreatment #semaglutide #Liraglutide #tirzepatide #diabetesmedicines #healthawareness #upsc2025 #currentaffairs2025 #weightlossdrugs #foodcravings #BrainAndFood #medicalethics #currentaffairs #latestnews #sanskritipcs 👉 Do you think about food all the time even when you are not hungry? This is called – ‘Food Noise’ – a neuropsychological condition, which is now becoming the new cause of obesity and diabetes. Now it is being treated – through GLP-1 drugs like: Semaglutide, Liraglutide, Tirzepatide. 📌 Know in this video: ✅ What is 'Food Noise' and why does it happen? ✅ What is GLP-1 and how do these drugs work? ✅ What are brands like Semaglutide, Ozempic, Mounjaro used for? ✅ What are its benefits and side effects? ✅ Is it becoming a fashion now? ✅ Status and legal direction of these drugs in India 👉 क्या आप बिना भूख के भी हर समय खाने की सोच में रहते हैं? इसे ही कहा जाता है — ‘Food Noise’ — एक न्यूरोसाइकोलॉजिकल कंडीशन, जो अब मोटापा और डायबिटीज़ की नई वजह बनती जा रही है। अब इसका इलाज मिल रहा है — GLP-1 दवाओं के ज़रिए जैसे: Semaglutide, Liraglutide, Tirzepatide। 📌 इस वीडियो में जानिए: ✅ 'Food Noise' क्या है और क्यों होता है? ✅ GLP-1 क्या है और ये दवाएं कैसे काम करती हैं? ✅ Semaglutide, Ozempic, Mounjaro जैसे ब्रांड्स किस लिए प्रयोग हो रहे हैं? ✅ इसके फायदे और साइड इफेक्ट्स क्या हैं? ✅ क्या यह अब एक फैशन बनता जा रहा है? ✅ भारत में इन दवाओं की स्थिति और कानूनी दिशा 📌 Don’t forget to Like, Share, and Subscribe ================================= 👉 Download Sanskriti IAS APP: https://bit.ly/394fDnq 👉 Request a Call Back: https://shorturl.at/oQV01 👉 Call: 9555-124-124 👉 WhatsApp Channel: https://shorturl.at/oN347 ================================= Our Important Playlists 👇 ✅ Current Affairs 2025: https://tinyurl.com/ma3j5hde ✅ Latest Current Affairs: https://tinyurl.com/wp73c3ez ✅ BPSC - Bihar Special & 71st BPSC Mission SDM: https://tinyurl.com/2zm3r8pe ✅ बिहार जिला दर्शन | Bihar Districts Series:https://tinyurl.com/pan2nxmw ✅ 71st BPSC Current Affairs: https://tinyurl.com/yvt6yjhx ✅ UPDATE EXPRESS: https://tinyurl.com/2f78snsu ✅ UPPCS RO/ARO 2025 (Geography): https://shorturl.at/t1lkm ✅ UPPCS RO/ARO 2025 ( History ): https://shorturl.at/3frG1 ✅ UP RO/ARO 2024 -25, Daily 10 MCQs: https://shorturl.at/EeL3K ✅ Uttar Pradesh schemes: https://tinyurl.com/y6ex3hyz ================================= ✅ 𝐅𝐨𝐫 𝐒𝐚𝐧𝐬𝐤𝐫𝐢𝐭𝐢 𝐈𝐀𝐒 𝐮𝐩𝐝𝐚𝐭𝐞𝐬 𝐟𝐨𝐥𝐥𝐨𝐰 𝐮𝐬 𝐚𝐭: ► 𝐓𝐞𝐥𝐞𝐆𝐫𝐚𝐦: https://t.me/sanskritiias ► 𝐅𝐚𝐜𝐞𝐁𝐨𝐨𝐤: https://www.facebook.com/sanskritiias ► 𝐈𝐧𝐬𝐭𝐚𝐆𝐫𝐚𝐦: https://www.instagram.com/sanskritiias/ ► 𝐓𝐰𝐢𝐭𝐭𝐞𝐫: https://twitter.com/sanskritiias 𝗔𝗱𝗱𝗿𝗲𝘀𝘀: 636, Ground Floor, Dr. Mukherjee Nagar, Delhi – 110009 𝐂𝐨𝐧𝐭𝐚𝐜𝐭 𝐮𝐬 : 9555 124 124 / 74280 85757 Visit: www.sanskritiias.com ================================= #71bpsc #bpsc71st #currentaffairs2025 #bihargk #bpscprelims2025 #bpscupdates #biharnews #currentaffairs2025 #bpsc2025 #uppcs2025 #ras2025 #MPPCS2025 #StatePCS2025 #pcsexampreparation #currentaffairstoday #dailycurrentaffairs #upscandpcsdifference #GKForPCS #StaticAndCurrent #PCSExamUpdate #currentforbpsc #RASGK2025 #MPPCSNotes #CurrentAffairsQuiz #PCS2025Target #ExamWithCurrentAffairs #BPSCPreparation#pcs #uppcs #uppcs2025 #bpsc #mppsc #ras #sanskritiias #sanskriti #iasprelims #pcsprelims2025 #pcsexam #pcsexampreparation #sanskritipcs

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Food addiction isn't about willpower. It’s about biology. This week’s guest, Dr. David A. Kessler, pulls back the curtain on GLP-1 drugs, the medications everyone's talking about but few truly understand. As a former FDA Commissioner, bestselling author of Diet, Drugs, and Dopamine, and someone who has personally used Ozempic, Dr. David reveals what pharmaceutical companies aren't telling you about how they actually work. David shares his own journey with GLP-1 medications, the science behind why they're so effective, and the critical conversations we're not having about safety, proper use, and what happens when you stop taking them. Through science, candor, and vulnerability, he explains: - Why food addiction is real, and how it rewires the reward circuits of the brain - How GLP-1 drugs like Ozempic are changing the conversation about obesity and self-blame - Why “just eat less” doesn’t work… and never did - How visceral fat creates an invisible storm of inflammation, starting in childhood - And what it means to actually change your relationship with food for good Dr Kessler doesn’t offer a magic solution. He offers tools: from nutritional rewiring to behavioral insight, from emotional honesty to policy change. Ultimately, he reminds us that health isn’t about being perfect. It’s about understanding what drives us, learning how to interrupt the cycle, and reclaiming agency in a world designed to overwhelm it. Real healing isn’t about restriction. It’s about relief. It’s not about weight. It’s about freedom. Love, Sarah Ann 💛 *** If you enjoyed this episode you might also like: Dr. Chris Palmer: How Ultra-Processed Foods Impact Your Brain and Mental Health https://www.youtube.com/watch?v=1XwRdDU1PCY Dr. Chris Van Tulleken: How Ultra-Processed Foods Are Making Us Sick https://www.youtube.com/watch?v=6SxK9MFmH4c 3 Foods to END Cravings, Sugar Addiction & Get Your Energy Back | Glucose Goddess Jessie Inchauspé https://www.youtube.com/watch?v=sdfNy_UCqng *** Sign up to Sarah’s Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/ *** Highlights: 0:00:00 – Introduction: Why Is It So Hard to Lose Weight and Keep It Off? 0:10:12 – Dopamine, Cravings, and the Science of Food Addiction 0:15:14 – How GLP-1 Drugs Like Ozempic Actually Work for Weight Loss 0:20:06 – How to Change Your Relationship with Food 0:23:37 – GLP-1 Drug Risks, Malnutrition & Eating Disorders 0:27:07 – Is Ozempic Being Misused? The Dangers of Microdosing 0:31:53 – How to Safely Use GLP-1s and Maintain Weight Loss After Stopping 0:33:43 – Which Diet Is Best? Low-Fat vs. Mediterranean vs. Low-Carb 0:40:55 – How to Lose Visceral Fat Without GLP-1 Drugs 0:42:44 – Root Cause of Obesity Crisis 0:51:49 – Living Well: A Redefinition of Health and Self-Acceptance *** Let’s be friends! 📷 Instagram: / sarahannmacklin 📹 Subscribe: / @livewellbewellsarah 🐦 Twitter: / sarahannmacklin 📱 TikTok: / sarahannnutrition 💌 Newsletter: https://sarahmacklin.substack.com/

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